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Drug Discov Today. 2018 Jan 12. pii: S1359-6446(17)30343-4. doi: 10.1016/j.drudis.2018.01.028. [Epub ahead of print]
Influenza A virus polymerase: an attractive target for next-generation anti-influenza therapeutics.
Zhou Z1, Liu T1, Zhang J1, Zhan P2, Liu X3.
Author information
Abstract
The influenza RNA-dependent RNA polymerase (RdRP) is conserved among different types of influenza virus, playing an important part in transcription and replication. In this regard, influenza RdRP is an attractive target for novel anti-influenza drug discovery. Herein, we will introduce the structural and functional information of influenza polymerase; and an overview of inhibitors targeting the PA endonuclease and PB2 cap-binding site is provided, along with the approaches utilized for identification of these inhibitors. The protein-protein interactions (PPIs) of the three polymerase subunits: PA, PB1 and PB2, are described based on the published crystal structures, and inhibitors targeting the PA-PB1 interaction are introduced briefly.
KEYWORDS:
PA endonuclease; PB2 cap-binding site; PPI; Polymerase; drug design
PMID: 29339107 DOI: 10.1016/j.drudis.2018.01.028
Influenza A virus polymerase: an attractive target for next-generation anti-influenza therapeutics.
Zhou Z1, Liu T1, Zhang J1, Zhan P2, Liu X3.
Author information
Abstract
The influenza RNA-dependent RNA polymerase (RdRP) is conserved among different types of influenza virus, playing an important part in transcription and replication. In this regard, influenza RdRP is an attractive target for novel anti-influenza drug discovery. Herein, we will introduce the structural and functional information of influenza polymerase; and an overview of inhibitors targeting the PA endonuclease and PB2 cap-binding site is provided, along with the approaches utilized for identification of these inhibitors. The protein-protein interactions (PPIs) of the three polymerase subunits: PA, PB1 and PB2, are described based on the published crystal structures, and inhibitors targeting the PA-PB1 interaction are introduced briefly.
KEYWORDS:
PA endonuclease; PB2 cap-binding site; PPI; Polymerase; drug design
PMID: 29339107 DOI: 10.1016/j.drudis.2018.01.028