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Curr Drug Metab. 2017 Sep 24. doi: 10.2174/1389200218666170925115132. [Epub ahead of print]
Virus-host interactions: new insights and advancements in drug development against viral pathogens.
Prasad M1, Ranjan K2, Brar B1, Shah I1, Lalmbe U1, Manimegalai J1, Vashisht B1, Gaury M1, Kumar P1, Khurana SK3, Prasad G4, Rawat J5, Yadav V5, Kumar S6, Rao R6.
Author information
Abstract
Viruses are the most devastating pathogens of almost all life forms including humans and animals. Viruses can replicate very fast and may affect any metabolic and physiological function of the host cell. Therefore, it has been a challenge to develop a universal and common treatment against viral pathogens, in contrast to bacterial pathogens. Virus-host interaction is a complex phenomenon and often is virus- and host cell-specific. Exciting new insights into the molecular pathogenesis and host-virus interactions have been gained over the past few decades. These advances have enabled researchers to design better antiviral drugs. Clinical adequacy of antiviral drugs and their bioavailability are important parameters for effective treatment of viral infections. The problems associated with effective delivery of a drug in a safe and desired quantity have led to the search for (and design of) better drug delivery systems. In recent past, several new antiviral drugs have been developed, which have high therapeutic effectiveness against life-threatening viral diseases such as HIV, hepatitis B virus, herpes virus, dengue virus, and influenza virus infections. The majority of recent advances in antiviral drug discovery were possible due to developments in allied fields such as in vitro virus cultivation technology, molecular biology of viral-genome-encoded enzymes, complete-genome-sequence-based studies of viruses, and identification of suitable targets for antiviral drugs in viral genomes. Recently, several novel drug delivery approaches including small interfering RNAs (siRNAs) have emerged to aid antiviral therapy. The present review is aimed at providing an update on research and development efforts being made to create effective antiviral chemotherapeutic agents and approaches to their delivery to appropriate cells or tissues.
Copyright? Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
KEYWORDS:
Antiviral drugs; HIV; Interferon; drug delivery; hepatitis virus
PMID: 28952435 DOI: 10.2174/1389200218666170925115132
Virus-host interactions: new insights and advancements in drug development against viral pathogens.
Prasad M1, Ranjan K2, Brar B1, Shah I1, Lalmbe U1, Manimegalai J1, Vashisht B1, Gaury M1, Kumar P1, Khurana SK3, Prasad G4, Rawat J5, Yadav V5, Kumar S6, Rao R6.
Author information
Abstract
Viruses are the most devastating pathogens of almost all life forms including humans and animals. Viruses can replicate very fast and may affect any metabolic and physiological function of the host cell. Therefore, it has been a challenge to develop a universal and common treatment against viral pathogens, in contrast to bacterial pathogens. Virus-host interaction is a complex phenomenon and often is virus- and host cell-specific. Exciting new insights into the molecular pathogenesis and host-virus interactions have been gained over the past few decades. These advances have enabled researchers to design better antiviral drugs. Clinical adequacy of antiviral drugs and their bioavailability are important parameters for effective treatment of viral infections. The problems associated with effective delivery of a drug in a safe and desired quantity have led to the search for (and design of) better drug delivery systems. In recent past, several new antiviral drugs have been developed, which have high therapeutic effectiveness against life-threatening viral diseases such as HIV, hepatitis B virus, herpes virus, dengue virus, and influenza virus infections. The majority of recent advances in antiviral drug discovery were possible due to developments in allied fields such as in vitro virus cultivation technology, molecular biology of viral-genome-encoded enzymes, complete-genome-sequence-based studies of viruses, and identification of suitable targets for antiviral drugs in viral genomes. Recently, several novel drug delivery approaches including small interfering RNAs (siRNAs) have emerged to aid antiviral therapy. The present review is aimed at providing an update on research and development efforts being made to create effective antiviral chemotherapeutic agents and approaches to their delivery to appropriate cells or tissues.
Copyright? Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
KEYWORDS:
Antiviral drugs; HIV; Interferon; drug delivery; hepatitis virus
PMID: 28952435 DOI: 10.2174/1389200218666170925115132