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Anti-influenza activity of monoterpene-derived substituted hexahydro-2H-chromenes

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  • Anti-influenza activity of monoterpene-derived substituted hexahydro-2H-chromenes

    Bioorg Med Chem. 2016 Aug 22. pii: S0968-0896(16)30644-7. doi: 10.1016/j.bmc.2016.08.037. [Epub ahead of print]
    Anti-influenza activity of monoterpene-derived substituted hexahydro-2H-chromenes.

    Patrusheva OS1, Zarubaev VV2, Shtro AA3, Orshanskaya YR3, Boldyrev SA3, Ilyina IV4, Kurbakova SY1, Korchagina DV1, Volcho KP4, Salakhutdinov NF4.
    Author information

    Abstract

    The antiviral activity of 4-hydroxy-hexahydro-2H-chromenes and 4-fluorine-hexahydro-2H-chromenes with an aromatic substituent, synthesized from monoterpene (-)-verbenone, was studied for the first time. Five of 11 (45 per cent) of 4-hydroxy-hexahydro-2H-chromene-type compounds have been found to exhibit antiviral activity against influenza A virus of subtype H1N1pdm09. Although a portion of active compounds among 4-fluorine-containing series was fewer, just compound 5i that contains a fluorine substituent exhibited more potent anti-influenza activity along with low cytotoxicity. Thus two new promising types of antiviral compounds were identified.
    Copyright ? 2016 Elsevier Ltd. All rights reserved.


    KEYWORDS:

    Antiviral; Chromene; Influenza; Monoterpene

    PMID: 27591012 DOI: 10.1016/j.bmc.2016.08.037
    [PubMed - as supplied by publisher]
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