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Influenza Other Respir Viruses. 2016 Jul 21. doi: 10.1111/irv.12415. [Epub ahead of print]
Oseltamivir resistance in an influenza A (H3N2) virus isolated from an immunocompromised patient during the 2014-2015 influenza season in Alberta, Canada.
Chaudhry A1, Bastien N2, Li Y2, Scott A3, Pabbaraju K4, Stewart D1, Wong S4, Drews SJ5,6.
Author information
Abstract
This manuscript describes the identification of an oseltamivir resistant influenza A (H3N2) virus in a respiratory specimen collected from an immunocompromised patient in Alberta, Canada during the 2014-2015 influenza season. Following treatment with oseltamivir, neuraminidase (NA) gene sequencing indicated the presence of an R292K mutation. Phenotypic susceptibility testing by the NA-Star assay indicated a highly reduced inhibition by oseltamivir and normal inhibition by zanamivir. The use of zanamivir following identification of the oseltamivir resistant strain, combined with a partial immune reconstitution was followed by a suggested decrease in the nasopharyngeal viral load in the nasopharynx and clinical improvement of the patient. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
KEYWORDS:
H3N2; Influenza; Neuraminidase inhibitors; Reduced susceptibility; Resistance; Sequence analysis
PMID: 27442795 DOI: 10.1111/irv.12415
[PubMed - as supplied by publisher]
Oseltamivir resistance in an influenza A (H3N2) virus isolated from an immunocompromised patient during the 2014-2015 influenza season in Alberta, Canada.
Chaudhry A1, Bastien N2, Li Y2, Scott A3, Pabbaraju K4, Stewart D1, Wong S4, Drews SJ5,6.
Author information
Abstract
This manuscript describes the identification of an oseltamivir resistant influenza A (H3N2) virus in a respiratory specimen collected from an immunocompromised patient in Alberta, Canada during the 2014-2015 influenza season. Following treatment with oseltamivir, neuraminidase (NA) gene sequencing indicated the presence of an R292K mutation. Phenotypic susceptibility testing by the NA-Star assay indicated a highly reduced inhibition by oseltamivir and normal inhibition by zanamivir. The use of zanamivir following identification of the oseltamivir resistant strain, combined with a partial immune reconstitution was followed by a suggested decrease in the nasopharyngeal viral load in the nasopharynx and clinical improvement of the patient. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
KEYWORDS:
H3N2; Influenza; Neuraminidase inhibitors; Reduced susceptibility; Resistance; Sequence analysis
PMID: 27442795 DOI: 10.1111/irv.12415
[PubMed - as supplied by publisher]