Re: :::Emergence of seasonal influenza viruses type A/H1N1 with:::
Thank you ironorehopper, and Dr. Niman:
"... Clade 1 viruses appear to be 15 to 30 times more sensitive to oseltamivir than clade 2 isolates from Indonesia and Turkey,56,57 although the possible clinical relevance of such differences in oseltamivir susceptibility remains to be determined.
During oseltamivir therapy, the emergence of highly resistant variants with an H274Y neuraminidase mutation may be associated with a fatal outcome. ..."
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Influenza experts admitted today that they have been startled by the discovery this season of an unexpectedly high number of human flu viruses that appear to be naturally resistant to Tamiflu, the drug that countries around the world are stockpiling for use in the next flu pandemic.
The viruses have been isolated from people infected with influenza A viruses of the H1N1 subtype in a number of European countries.
And Canada's National Microbiology Laboratory in Winnipeg has reported finding one such virus, in a child who is believed to have been infected with influenza in Sudan before travelling to Canada.
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"... At the Los Alamos sequence database, there are 1030 N1 sequences from H1N1 human isolates. 340 are from 2007 and all of the sequences below are from 2007.
Thus, although the percentage of samples was low, all were from 2007 and all were Solomon Island-like.
These Solomon-Island lake sequences trace back to Asia, where Tamiflu blankets are frequently applied in the treatment of H5N1.
The N1 in H5N1 has donor sequences for human N1 in the region adjacent to the acquisition which generates H274Y, which is the precise change found in the most common form of oseltamivir resistance in H5N1 patients, primarily in Vietnam. ..."
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From the above, the Tamiflu blankets aplied on humans beeing infected also/only with seasonal flu, induced an insurgence of an Tamiflu resistant strain of human seasonal flu AH1N1, which is now disseminated in USA/Canada/Europe/.../.
On the other side EU wroted:
"... Therefore it can be assumed that viruses carrying the H274Y mutation represent community influenza transmissions in Europe (rather than importations or a focused outbreak).""
Thank you ironorehopper, and Dr. Niman:
"... Clade 1 viruses appear to be 15 to 30 times more sensitive to oseltamivir than clade 2 isolates from Indonesia and Turkey,56,57 although the possible clinical relevance of such differences in oseltamivir susceptibility remains to be determined.
During oseltamivir therapy, the emergence of highly resistant variants with an H274Y neuraminidase mutation may be associated with a fatal outcome. ..."
___
Influenza experts admitted today that they have been startled by the discovery this season of an unexpectedly high number of human flu viruses that appear to be naturally resistant to Tamiflu, the drug that countries around the world are stockpiling for use in the next flu pandemic.
The viruses have been isolated from people infected with influenza A viruses of the H1N1 subtype in a number of European countries.
And Canada's National Microbiology Laboratory in Winnipeg has reported finding one such virus, in a child who is believed to have been infected with influenza in Sudan before travelling to Canada.
___
"... At the Los Alamos sequence database, there are 1030 N1 sequences from H1N1 human isolates. 340 are from 2007 and all of the sequences below are from 2007.
Thus, although the percentage of samples was low, all were from 2007 and all were Solomon Island-like.
These Solomon-Island lake sequences trace back to Asia, where Tamiflu blankets are frequently applied in the treatment of H5N1.
The N1 in H5N1 has donor sequences for human N1 in the region adjacent to the acquisition which generates H274Y, which is the precise change found in the most common form of oseltamivir resistance in H5N1 patients, primarily in Vietnam. ..."
___
From the above, the Tamiflu blankets aplied on humans beeing infected also/only with seasonal flu, induced an insurgence of an Tamiflu resistant strain of human seasonal flu AH1N1, which is now disseminated in USA/Canada/Europe/.../.
On the other side EU wroted:
"... Therefore it can be assumed that viruses carrying the H274Y mutation represent community influenza transmissions in Europe (rather than importations or a focused outbreak).""
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