Biomed J. 2018 Aug;41(4):242-248. doi: 10.1016/j.bj.2018.08.003. Epub 2018 Sep 11.
Legacy of the influenza pandemic 1918: The host T cell response.
McMichael AJ1.
Author information
Abstract
The influenza virus was instrumental in unravelling critical aspects of the antiviral T lymphocyte mediated immune response. A major finding was the demonstration that CD8 T lymphocytes recognize short viral peptides presented by class I molecules of the major histocompatibility complex. Studies of influenza specific T cells have also led to an understanding of their important role in recovery from influenza virus infection in humans.
KEYWORDS:
Influenza; T lymphocytes
PMID: 30348267 DOI: 10.1016/j.bj.2018.08.003
Free full text
Legacy of the influenza pandemic 1918: The host T cell response.
McMichael AJ1.
Author information
Abstract
The influenza virus was instrumental in unravelling critical aspects of the antiviral T lymphocyte mediated immune response. A major finding was the demonstration that CD8 T lymphocytes recognize short viral peptides presented by class I molecules of the major histocompatibility complex. Studies of influenza specific T cells have also led to an understanding of their important role in recovery from influenza virus infection in humans.
KEYWORDS:
Influenza; T lymphocytes
PMID: 30348267 DOI: 10.1016/j.bj.2018.08.003
Free full text