Western PA. flu on the upswing

[JimO]

Western PA. flu on the upswing
January 4, 2014 12:03 AM
By Amy McConnell Schaarsmith / Pittsburgh Post-Gazette

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In Allegheny County, 159 cases of confirmed and suspected flu were reported as of Dec. 28, including one flu-related death of a 62-year-old woman, according to Dr. Hacker. In addition, the state reported 121 cases in Butler County, 89 cases in Westmoreland, 74 cases in Beaver, 66 cases in Washington County, 63 in Fayette County and 9 each in Greene and Armstrong counties during that period.

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http://www.post-gazette.com/news/health/2014/01/04/Flu-is-on-the-rise-again-in-Western-Pennsylvania/stories/201401040112

[NS1]

Re: Western PA. flu on the upswing

pH1N1 Child Vaccine Escape
CDC Early 2013

Map - Active and Detailed

<div style="text-align: center;">
<hr style="width: 30%;" />41 Cases over 43 Sequences<hr style="width: 30%;" /></div>
Introduction

In the 30 days covering 2013-02-28 to 2013-03-29, the&nbsp;<span style="color: #783f04;"><b>United States CDC</b></span>&nbsp;released a total of 43&nbsp;<b><span style="color: #632423; font-family: &quot;Trebuchet MS&quot;;">pH1N1</span></b>&nbsp;sequences at&nbsp;<strong>GISAID&nbsp;</strong>on 41 human cases<strong>&nbsp;</strong>sampled from October 2012 to February 2013. Geographic surveillance includes&nbsp;<b>America,</b>&nbsp;<b>Africa, Asia </b>and<b> Russia.&nbsp;</b>Although&nbsp;<b><span style="color: #632423; font-family: &quot;Trebuchet MS&quot;;">pH1N1</span></b>&nbsp;in most locales during the&nbsp;2012-2013 season was the <b><span style="color: #783f04;">minority</span></b> serotype, the sequences in this Analytic Report describe a high level of human-infective diversity and an ease of avian genetic acquisition, including multiple instances demonstrating concentrated transport of <b><span style="color: #660000;">High-CFR</span></b>&nbsp;<b><span style="color: #632423; font-family: &quot;Trebuchet MS&quot;;">pH1N1&nbsp;</span><span style="color: #783f04;">Upsilon</span></b> polymorphisms onto single sequences.

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Read the Open-Access, Full-Text
Investigational Analytic
including Genetic Details

[NS1]

Re: Western PA. flu on the upswing

pH1N1 Drug Resistant Low Reactor
CDC Fall 2013

Map - Active and Detailed

<div style="text-align: center;">
<hr style="width: 30%;" />46 Cases over 49 Sequences<hr style="width: 30%;" /></div>
Introduction

In the 32 days covering 2013-10-17 to 2013-11-19, the&nbsp;<span style="color: #783f04;"><b>United States CDC</b></span>&nbsp;released a total of 49&nbsp;<b><span style="color: #632423; font-family: &quot;Trebuchet MS&quot;;">pH1N1</span></b>&nbsp;sequences at&nbsp;<strong>GISAID&nbsp;</strong>on 46 human cases<strong>&nbsp;</strong>sampled from February 2013 to October 2013. Geographic surveillance includes&nbsp;<b>America,</b>&nbsp;<b>Africa, Asia, Brazil, Ecuador, Paraguay&nbsp;</b>and<b>&nbsp;Peru.&nbsp;</b>

The sequences in this Analytic Report describe a high level of genetic activity at the <b><span style="color: #274e13;">Hemagglutinin</span></b> <b><span style="color: #660000;">antigenic area</span></b> between <b><span style="color: blue;">aa155</span></b> and <b><span style="color: blue;">aa158</span></b> with <b>5</b> amino variations and <b>4</b> silent revisions. &nbsp; <b><span style="color: #274e13;">HA</span></b> <b><span style="color: blue;">225G</span></b> is present in <b><span style="color: #660000;">quasi-species</span></b> on <b>2</b>&nbsp;American samples and as dominant form in <b>2</b> tropical countries. The <b>Dominican Republic</b> <b><span style="color: #274e13;">HA</span></b> <b><span style="color: blue;">225G</span></b>&nbsp;<b><span style="color: #660000;">Low Reactor</span></b> appears on a <b><span style="color: #7f6000;">TamiFlu Resistant</span></b> strain. &nbsp;<b><span style="color: #7f6000;">Drug Resistance</span></b> is also found in <b>2</b> US sequences and <b>1</b> South American case.
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Read the Open-Access, Full-Text
Investigational Analytic
including Genetic Details