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Anti-viral resistance in 2009 A/H1N1 flu - historical compilation of news

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  • Re: Anti-viral resistance in 2009 A/H1N1 flu - historical compilation of news

    01 June 2011 ‐‐ For this reporting period (18 May ‐ 01 June 2011), 16 new cases of influenza A (H1N1) 2009 viruses carrying the H275Y substitution have been reported. It brings the cumulative total to 508 so far.

    Comparison of the WHO updates in May 2010 and June 2011; notice that they changed the a couple of the colors in the chart.



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    The salvage of human life ought to be placed above barter and exchange ~ Louis Harris, 1918

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    • Anti-viral resistance in 2009 A/H1N1 flu - historical compilation of news

      It appears that 19 of the 29 people in this study with oseltamivir resistant A/H1N1pdm09 had no known links to each other. i.e. Possible community spread of oseltamivir resistant A/H1N1pdm09.

      Community Transmission of Oseltamivir-Resistant A(H1N1)pdm09 Influenza
      N Engl J Med 2011; 365:2541-2542
      December 29, 2011


      snip

      A fluorescence-based neuraminidase inhibition assay5 of the H275Y isolates showed that the IC50 value (the concentration of drug required to inhibit neuraminidase activity by 50%) was 513 times higher for oseltamivir and 80 times higher for peramivir than the IC50 values associated with wild-type strains.

      snip

      Hospital records and interviews with patients and general practitioners revealed that only 1 of the 29 patients with resistant influenza had received oseltamivir before the influenza specimen collection

      snip

      Four households had 2 affected patients each, and 2 other patients shared a short car journey. The remaining patients had no known epidemiologic link with the other patients with oseltamivir-resistant influenza described here.

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