If you are sitting comfortably I am going to tell you a story about a great battle in the war.
We knew they were going to attack; it was only a matter of time. All our forces broadcast our friend or foe signal MHC and we had the signals scouts from B company & T company troops who knew what some of the enemy looked like - I wished we had more like them. When they came they were a new foe coming down blood road, no one initially recognised them, signals first suspected them, B cell changed over to Plasma Cell mode to broadcast their description in an antibody. Now the game was up with the antibody description plastered all over them they were easy to spot. The Killer T cells (CTLs) attacked lobbing granulocytes (chemical grenades, histamine and all kinds of toxic stuff), the NKs (Natural Killers) were already there because they had not detected an MHC so they just went in granulites blazing then there were the enormous Phagocytes, Monocytes gobbling up the enemy and Neutrophiles eating them and detonating granulocytes on them once confined. As if the battle was not dangerous enough the eosinphiles & basophiles were spraying toxic chemicals everywhere on us and them – very inflammatory! Meanwhile the signals section of the T cells sent out a stream lymphokine cytokines giving instruction to the whole army: whether new stem cells should be trained up into T (that’s an IL2), B, NK or phagocytes, calling more troops to hotspots (chemokines) and generally controlling the battle. Not to be outdone the Phagocytes had their macrophages & monocytes broadcasting monokine cytokines giving similar orders, the air was so thick with interlukine cytokines it was difficult to see. The battle was touch and go when B cells sent out an IgG antigen calling in the complement, about 25 proteins cascaded into the enemy forming an opening and it was guts all over blood street. After that it was mainly mopping up operations, some of the monocytes stopped patrolling blood street changed to macrophages and chased the enemy who had escaped into the tissues others phagocytes cleaned up the debris. Many of T & B company were disbanded but we always keep a few who can recognise them if they come back - and we have their antigen ready to broadcast – they will be sorry if they show there faces around here again. I feel it only fair to mention the T helper cells, while not in the thick of it they activated new T & B cells and called in macrophages but never get a mention in dispatches. I will try and find my old code book so I can show you some of those messages in the cytokines and immunoglobulin antibodies but that is a story for another time.
Yes, it is confirmed, I am mad. I just have a visual memory and am awful with names, if I can thinks of it as a system it sinks in better.
We knew they were going to attack; it was only a matter of time. All our forces broadcast our friend or foe signal MHC and we had the signals scouts from B company & T company troops who knew what some of the enemy looked like - I wished we had more like them. When they came they were a new foe coming down blood road, no one initially recognised them, signals first suspected them, B cell changed over to Plasma Cell mode to broadcast their description in an antibody. Now the game was up with the antibody description plastered all over them they were easy to spot. The Killer T cells (CTLs) attacked lobbing granulocytes (chemical grenades, histamine and all kinds of toxic stuff), the NKs (Natural Killers) were already there because they had not detected an MHC so they just went in granulites blazing then there were the enormous Phagocytes, Monocytes gobbling up the enemy and Neutrophiles eating them and detonating granulocytes on them once confined. As if the battle was not dangerous enough the eosinphiles & basophiles were spraying toxic chemicals everywhere on us and them – very inflammatory! Meanwhile the signals section of the T cells sent out a stream lymphokine cytokines giving instruction to the whole army: whether new stem cells should be trained up into T (that’s an IL2), B, NK or phagocytes, calling more troops to hotspots (chemokines) and generally controlling the battle. Not to be outdone the Phagocytes had their macrophages & monocytes broadcasting monokine cytokines giving similar orders, the air was so thick with interlukine cytokines it was difficult to see. The battle was touch and go when B cells sent out an IgG antigen calling in the complement, about 25 proteins cascaded into the enemy forming an opening and it was guts all over blood street. After that it was mainly mopping up operations, some of the monocytes stopped patrolling blood street changed to macrophages and chased the enemy who had escaped into the tissues others phagocytes cleaned up the debris. Many of T & B company were disbanded but we always keep a few who can recognise them if they come back - and we have their antigen ready to broadcast – they will be sorry if they show there faces around here again. I feel it only fair to mention the T helper cells, while not in the thick of it they activated new T & B cells and called in macrophages but never get a mention in dispatches. I will try and find my old code book so I can show you some of those messages in the cytokines and immunoglobulin antibodies but that is a story for another time.
Yes, it is confirmed, I am mad. I just have a visual memory and am awful with names, if I can thinks of it as a system it sinks in better.
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