Discussion - Long COVID

[Emily]

https://fortune.com/well/2022/11/29/...ovid-symptoms/
9 at-home exercises that may help relieve your long COVID symptoms

BY Barbara Brody
November 29, 2022, 6:00 PM UTC

[Emily]

https://onlinelibrary.wiley.com/doi/...002/acn3.51631
Tziastoudi, M., Cholevas, C., Stefanidis, I. and Theoharides, T.C. (2022), Genetics of COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review. Ann Clin Transl Neurol, 9: 1838-1857. https://doi.org/10.1002/acn3.51631
Abstract

COVID-19 and ME/CFS present with some similar symptoms, especially physical and mental fatigue. In order to understand the basis of these similarities and the possibility of underlying common genetic components, we performed a systematic review of all published genetic association and cohort studies regarding COVID-19 and ME/CFS and extracted the genes along with the genetic variants investigated. We then performed gene ontology and pathway analysis of those genes that gave significant results in the individual studies to yield functional annotations of the studied genes using protein analysis through evolutionary relationships (PANTHER) VERSION 17.0 software. Finally, we identified the common genetic components of these two conditions. Seventy-one studies for COVID-19 and 26 studies for ME/CFS were included in the systematic review in which the expression of 97 genes for COVID-19 and 429 genes for ME/CFS were significantly affected. We found that ACE, HLA-A, HLA-C, HLA-DQA1, HLA-DRB1, and TYK2 are the common genes that gave significant results. The findings of the pathway analysis highlight the contribution of inflammation mediated by chemokine and cytokine signaling pathways, and the T cell activation and Toll receptor signaling pathways. Protein class analysis revealed the contribution of defense/immunity proteins, as well as protein-modifying enzymes. Our results suggest that the pathogenesis of both syndromes could involve some immune dysfunction.

[Emily]

So obesity and prior drinking history are risks. Go figure.

https://nypost.com/2023/01/20/long-c...searchers-say/
Long COVID may make your hangovers much worse, researchers say

By Adriana Diaz

January 20, 2023 6:59pm

Getting a positive COVID-19 test may not only affect the way people taste and smell alcohol — it may also change the way they process it.

Anecdotal data has found that some people have reported a change in how their bodies react to booze after testing positive for the coronavirus.

Rebekah Stein, 30, used to be able to hold her liquor before being diagnosed with COVID in March 2020, she told BuzzFeed News.

Then one night after her mild symptoms went away, she casually stole a sip of her husband’s whiskey, as she had done plenty of times before...