Alex Sigal
@sigallab
We have completed our first experiments on neutralization of Omicron by Pfizer BNT162b2 vaccination elicited immunity Manuscript available at https://sigallab.net and should be available on medRxiv in the coming days
4:02 PM · Dec 7, 2021·Twitter Web App
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Alex Sigal
@sigallab
·
13h
Replying to
@sigallab
There are a few results: 1. Omicron still uses ACE2 2. There is a very large drop in neutralization of Omicron by BNT162b2 immunity relative to ancestral virus 3. Omicron escape from BNT162b2 neutralization is incomplete. Previous infection + vaccination still neutralizes
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Alex Sigal
@sigallab
·
13h
This is our first set of data and is not corrected for values going below the lowest dilution used - we present the raw fold change, which is likely to be adjusted as we do more experiments.
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Alex Sigal
@sigallab
·
13h
Thank you
@Sandile_Cele22
for leading,
@KhadijaKhan24
,
@farinakarim
,
@Dr_L_Jackson
for making it possible, and our terrific collaborators
@PennyMo70026063
,
@Tuliodna
,
@rjlessells
,
@houzhou
. There are many more key people to thank, but I need to get some sleep first
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Alex Sigal
@sigallab
·
12h
Just be be clear on something as I'm still awake, this was better than I expected of Omicron. The fact that it still needs the ACE2 receptor and that escape is incomplete means its a tractable problem with the tools we got
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