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Ivermectin - A useful treatment for COVID-19 coronavirus? Some discussion and studies...

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  • #76
    All links in original post should now go directly to the source. Let me know if I missed one - Emily



    Dr. John Campbell

    1.15M subscribers a

    Goa, home medical kit with ivermectin, zinc and vitamin D
    Chief Minister Dr. Pramod Sawant in the presence of Minister for Health Shri
    https://www.thehindu.com/news/nation...le34532312.ece
    https://www.goa.gov.in/wp-content/up...9-Launched.pdf

    Pulse Oximeter Digital Thermometer Paracetamol tablets (15) Vitamin C tablets (30) Multivitamin tablets with Zinc (30) Vitamin D3 tablets (2 packs) Ivermectin 12mg tablets (10) Doxycycline 100mg tablets (10) Three-ply face masks (5) N-95 Masks (2) Sanitizer (100ml) Alcohol based Wipes (1 box with 20 plies) Gloves (2 pairs) UP Population 204 million
    https://www.hindustantimes.com/india...606229422.html
    https://www.thehindu.com/news/nation...le34540312.ece
    No fresh Covid cases in UP's 59 districts Last 24 hours, 191,446 samples tested 33 samples tested positive Test Positivity Rate, lower than 0.01
    Active caseload Currently 187 April, 310,783
    Factors to explain success
    Targeted testing of specific groups
    Early detection Contact tracing Isolation
    Free and timely provision of medicine kits and treatment to the rural populace $2.65 per person
    https://www.hindustantimes.com/citie...747649057.html
    State government, 50 lakh medical kits through village surveillance committees A team of doctors will supervise the administration of doses as well as distribution of the medical kits among the children in all 75 districts of the state
    https://medicalupdateonline.com/2021...reatment-kits/
    ugust 2020 Government Order (GO), ivermectin-based treatment kit
    People with mild or asymptomatic covid-19 Kept in home isolation
    Mild case Oxygen saturation more than 94% Moderate case Oxygen saturations 90-94%
    Indication for hospitalisation Oxygen saturations below 90%
    Of those testing positive 90% successfully treated at home 10% hospitalised
    Treatment pack Ivermectin Doxycycline Vitamin D Vitamin C Vitamin B Zinc Paracetamol Thermometer Pulse oximeter
    Local Covid Control Centres Twice-daily phone calls to household contacts to check on progress They asked for oxygen saturation levels and temperature readings
    Checked that ivermectin and doxycycline had been taken
    Dr Suryakant Head Department of Respiratory Medicine, King George Medical University, Lucknow, UP Overall mortality in 2020 in India was 2.4%
    Uttar Pradesh it was only 2.0% that is the beauty, that is the success story of ivermectin (Dr Suryakant is brand ambassador for covid vaccination in India) UP highlighted by WHO
    https://www.who.int/india/news/featu...-stop-covid-19
    https://journals.plos.org/plosone/ar...l.pone.0247163

    https://indianbarassociation.in/wp-c...AY-26-2021.pdf
    Uttarakhand Population 10 million
    https://economictimes.indiatimes.com...w/82572159.cms

    State-level clinical technical committee Chief Secretary Om Prakash to all district magistrates The panel has recommended the Ivermectin tablet as “mass chemoprophylaxis” to effectively control the surge of COVID-19 infection Official health advisory from CDC https://emergency.cdc.gov/han/2021/pdf/CDC_HAN_449.pdf
    Last edited by Emily; January 3, 2022, 05:35 PM.
    _____________________________________________

    Ask Congress to Investigate COVID Origins and Government Response to Pandemic.

    i love myself. the quietest. simplest. most powerful. revolution ever. ---- nayyirah waheed

    "...there’s an obvious contest that’s happening between different sectors of the colonial ruling class in this country. And they would, if they could, lump us into their beef, their struggle." ---- Omali Yeshitela, African People’s Socialist Party

    (My posts are not intended as advice or professional assessments of any kind.)
    Never forget Excalibur.

    Comment


    • JJackson
      JJackson commented
      Editing a comment
      I do not know who the CDC Health Alert Network are but I do not think they have anything to do with 'The CDC', they seem to be a pro-Ivermectin lobby.
      [EDIT] I dug a little deeper and the CDC Health Alert Network is part of the CDC but I can not see how it can be referenced as pro Ivermectin given the text says
      "Ivermectin is not authorized or approved by FDA for prevention or treatment of COVID-19. The National Institutes of Health’s (NIH) COVID-19 Treatment Guidelines Panel has also determined that there are currently insufficient data to recommend ivermectin for treatment of COVID-19."

      The Indian COVID kit is unfortunate as Ivermectin has yet to be shown to be effective and Doxycycline is an antibiotic which will not impact the virus but may well lead to resistance.
      Last edited by JJackson; October 3, 2021, 04:53 PM.

  • #77

    • #77.1
      JJackson commented
      Today, 03:27 PM
      I do not know who the CDC Health Alert Network are but I do not think they have anything to do with 'The CDC', they seem to be a pro-Ivermectin lobby.
      [EDIT] I dug a little deeper and the CDC Health Alert Network is part of the CDC but I can not see how it can be referenced as pro Ivermectin given the text says
      "Ivermectin is not authorized or approved by FDA for prevention or treatment of COVID-19. The National Institutes of Health’s (NIH) COVID-19 Treatment Guidelines Panel has also determined that there are currently insufficient data to recommend ivermectin for treatment of COVID-19."

      The Indian COVID kit is unfortunate as Ivermectin has yet to be shown to be effective and Doxycycline is an antibiotic which will not impact the virus but may well lead to resistance.
      Last edited by JJackson; Today, 04:53 PM.
    -----------------------------------------------------------

    I am so "over it" with the US health departments. They all disagree with each other in varying degrees. The mask fiasco is one example. This is why this site recommendation is to consult with your medical practitioner.

    As to the India situation - I really like John Campbell but these outbreaks run in waves and the India wave was hitting a downturn when the kits were distributed anyway. I am not sure there is any correlation between the wave downturn and some of the contents of the kits. Overall the kits are probably better than nothing since they include masks and an oximeter. Time will tell as the pandemic is not over.

    I would personally love it if any of the known and inexpensive drugs already available were a safe and effective alternative to a vaccine. I am just not convinced. I have not asked for ivermectin or hydroxy. I know that pandemics take a few years to run the cycle. I am not comfortable with taking either long term at this point. I am also not thrilled with two vaccine shots a year - for how long? A couple more years?

    If I sound frustrated it is because I am. Since I am high risk I have restricted my outings for more than a year. I was not happy to take the first rounds of vaccine and now I am trying to decide on the booster. Moderna is not approved yet for use as a booster so I have time to consider this. I am not happy about the available drugs either. Masks give some level of protection so I use them. I think as a high risk person I am fairly screwed for the next year at least. I just have to accept this - as irritating as it is.

    I know many people are just living as usual. And that is their choice. It is not mine. I respect other people's choices and I hope people respect mine.

    Comment


    • #78
      Source: https://www.bbc.com/news/health-58170809

      Ivermectin: How false science created a Covid 'miracle' drug
      By Rachel Schraer & Jack Goodman
      BBC Reality Check
      Published 18 hours ago

      Ivermectin has been called a Covid "miracle" drug, championed by vaccine opponents, and recommended by health authorities in some countries. But the BBC can reveal there are serious errors in a number of key studies that the drug's promoters rely on.

      For some years ivermectin has been a vital anti-parasitic medicine used to treat humans and animals.

      But during the pandemic there has been a clamour from some proponents for using the drug for something else - to fight Covid and prevent deaths.

      The health authorities in the US, UK and EU have found there is insufficient evidence for using the drug against Covid, but thousands of supporters, many of them anti-vaccine activists, have continued to vigorously campaign for its use...

      Comment


      • #79
        Originally posted by Shiloh View Post
        Source: https://www.bbc.com/news/health-58170809

        Ivermectin: How false science created a Covid 'miracle' drug
        By Rachel Schraer & Jack Goodman
        BBC Reality Check
        Published 18 hours ago

        Ivermectin has been called a Covid "miracle" drug, championed by vaccine opponents, and recommended by health authorities in some countries. But the BBC can reveal there are serious errors in a number of key studies that the drug's promoters rely on.

        For some years ivermectin has been a vital anti-parasitic medicine used to treat humans and animals.

        But during the pandemic there has been a clamour from some proponents for using the drug for something else - to fight Covid and prevent deaths.

        The health authorities in the US, UK and EU have found there is insufficient evidence for using the drug against Covid, but thousands of supporters, many of them anti-vaccine activists, have continued to vigorously campaign for its use...
        Dr. Campbell weighs in on this article. I agree 100% with his comment that he is greedy - he wants both effective vaccines and great treatment options. I do not know why the mantra culture to trying to make us choose? Why can't we have both?


        Comment


        • Emily
          Emily commented
          Editing a comment
          Dr. Campbell strikes again! Enjoyed.

      • #80

        Dr. John Campbell
        1.44M subscribers
        New Pfizer antiviral and ivermectin, a pharmacodynamic analysis New Pfizer antiviral, PF-07321332, C₂₃H₃₂F₃N₅O₄

        _____________________________________________

        Ask Congress to Investigate COVID Origins and Government Response to Pandemic.

        i love myself. the quietest. simplest. most powerful. revolution ever. ---- nayyirah waheed

        "...there’s an obvious contest that’s happening between different sectors of the colonial ruling class in this country. And they would, if they could, lump us into their beef, their struggle." ---- Omali Yeshitela, African People’s Socialist Party

        (My posts are not intended as advice or professional assessments of any kind.)
        Never forget Excalibur.

        Comment


        • #81
          bump this

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          • #82
            Keith Smith, who had been on a ventilator, received two doses of the controversial drug before his condition worsened. He died Sunday at age 52.

            Man whose wife won a court battle to treat his COVID-19 with ivermectin has died

            Mike Argento, York Daily Record
            Tue, December 14, 2021, 9:06 AM·7 min read

            Keith Smith, whose wife had gone to court to have his COVID-19 infection treated with ivermectin, died Sunday evening, a week after he received his first dose of the controversial drug.
            He was 52.
            Smith had been in UMPC Memorial for nearly three weeks and had been in the hospital’s intensive care unit in a medically induced coma on a ventilator since Nov. 21. He had been diagnosed with the virus on Nov. 10.

            ...

            She had kind words for the nurses at UPMC, writing “I still love you.” She wrote, “You cared for Keith for over 21 days. You dosed him with the medicines the doctors prescribed. You cleaned him and groomed him, moved him, propped him up, dealt with every mess, every smell, every trial. Everything. I appreciate you.

            “That’s all I’ll say about UPMC at this time,” she wrote. “You’re incredibly lucky to have the nurses you do, jackwads. Treat them better.”

            ...

            She described his last moments.

            “The nurses removed that cursed tube from his throat and he breathed on his own for a bit,” she wrote. “Then, slowly, the time between breaths lengthened. His heart hammered in his chest. Such a strong, valiant heart. Finally his pulse went to zero, his color paled immediately.

            “The man in that bed did not look like Keith. He was gaunt, with scabs on his cheeks from three weeks of torture, having that godforsaken vent attached to his face. He had a full beard and mustache. His hair had grown like a wild man.”
            ...
            An engineer, a Penn State fan and a Christian
            Keith Smith was a structural engineer, a vice president of a firm headquartered in Lancaster. He was a graduate of Penn State and was an avid fan of the Nittany Lions football team. He was active, his wife said, and enjoyed woodworking and skiing...
            ...
            She wrote, “I don’t want to remember my husband in that awful bed with that monstrous tube stuck in his throat. I want to erase the IVs, the wires, the lines, the feeding tube. I want to erase all of this.”

            She wrote that she had picked up a prescription for ivermectin the day before Thanksgiving. “I could have given him the drug on the sly. Yes, they would have caught me.” She described preparing the drug in a sterilized Rubbermaid cup to sneak it into the hospital before the court ruled on her lawsuit. “In the end, I didn't do it,” she wrote. “And that will forever be a cloak of guilt that will cover me in shame.”

            Instead, she wrote, “I waited for the stupid court order, a nine-day delay from the date I picked up the script in Paoli. Then, UPMC played nasty, vile, wicked games for two days and delayed further.”

            She wrote, “The only thing keeping me upright is sheer hate and venom. Don't lecture me - DO NOT. If you've been through this, you know precisely what this feels like. I hope it is momentary, but I'm pretty nasty when cornered, so don't hold your breath. And, if you haven't been through this, drop to your knees and thank GOD that He hasn't dumped this on you. Thank your lucky freaking stars. But do NOT, ever, lecture me or judge me. There but for God's grace go you. Trust me, you do not want this burden.”

            She concluded, “My heart will always have a Keith-sized hole in it. It will never go away. I will miss him until the day I expire.”
            _____________________________________________

            Ask Congress to Investigate COVID Origins and Government Response to Pandemic.

            i love myself. the quietest. simplest. most powerful. revolution ever. ---- nayyirah waheed

            "...there’s an obvious contest that’s happening between different sectors of the colonial ruling class in this country. And they would, if they could, lump us into their beef, their struggle." ---- Omali Yeshitela, African People’s Socialist Party

            (My posts are not intended as advice or professional assessments of any kind.)
            Never forget Excalibur.

            Comment


            • #83
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              • #84
                The New Hampshire Department of Children, Youth, and Families (DCYF) recently made some waves in our state when they attempted to remove two children from their home after learning that the father had administered Ivermectin to his teenage boy a few days earlier. The facts of the case paint a disturbing picture of authorities who … Weaponizing the State: Does NH DCYF Have a “Bitter Clingers” Problem? Read More »

                Weaponizing the State: Does NH DCYF Have a “Bitter Clingers” Problem?

                by Jim Kofalt / 20 December 2021
                The New Hampshire Department of Children, Youth, and Families (DCYF) recently made some waves in our state when they attempted to remove two children from their home after learning that the father had administered Ivermectin to his teenage boy a few days earlier.

                The facts of the case paint a disturbing picture of authorities who simply don’t respect their limits. There was clearly no ill intent and no meaningful risk to the child. Ivermectin is a safe FDA-approved medication with relatively minor potential side effects. It’s available over the counter in much of the world, and in fact, many medications that are readily available at your local grocery store are arguably far more dangerous, including acetaminophen, cough syrup, and even Epsom salts.

                Yet New Hampshire DCYF saw fit to issue a protective order, deploy their agents, and issue a “be on the lookout” notice to local police departments. They were willing to put the family, – including two young teenagers, – through the trauma of forcible separation and placement with strangers for an undetermined period.

                Fortunately, the parents quickly figured out what was going on; they were able to move the children to a safe location before DCYF could get to them. Legal proceedings are now underway. But there is much more to this story, and it has everything to do with who DCYF was dealing with.

                Related: DCYF Threatened to Take RebuildNH Co-founder Jr Hoell’s Children after He Reported Treating Them with Ivermectin

                The father in this case happens to be a former New Hampshire state legislator. He’s the co-founder of a group called ReOpenNH, which has spearheaded the fight against mask requirements, forced business closures, and vaccine mandates for most of the past two years...
                _____________________________________________

                Ask Congress to Investigate COVID Origins and Government Response to Pandemic.

                i love myself. the quietest. simplest. most powerful. revolution ever. ---- nayyirah waheed

                "...there’s an obvious contest that’s happening between different sectors of the colonial ruling class in this country. And they would, if they could, lump us into their beef, their struggle." ---- Omali Yeshitela, African People’s Socialist Party

                (My posts are not intended as advice or professional assessments of any kind.)
                Never forget Excalibur.

                Comment


                • #85
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                  • #86

                    Cureus


                    . 2022 Jan 15;14(1):e21272.
                    doi: 10.7759/cureus.21272. eCollection 2022 Jan.
                    Ivermectin Prophylaxis Used for COVID-19: A Citywide, Prospective, Observational Study of 223,128 Subjects Using Propensity Score Matching


                    Lucy Kerr 1 , Flavio A Cadegiani 2 3 , Fernando Baldi 4 , Raysildo B Lobo 5 , Washington Luiz O Assagra 6 , Fernando Carlos Proença 7 , Pierre Kory 8 , Jennifer A Hibberd 9 , Juan J Chamie-Quintero 10



                    AffiliationsFree PMC article

                    Abstract

                    Background: Ivermectin has demonstrated different mechanisms of action that potentially protect from both coronavirus disease 2019 (COVID-19) infection and COVID-19-related comorbidities. Based on the studies suggesting efficacy in prophylaxis combined with the known safety profile of ivermectin, a citywide prevention program using ivermectin for COVID-19 was implemented in Itajaí, a southern city in Brazil in the state of Santa Catarina. The objective of this study was to evaluate the impact of regular ivermectin use on subsequent COVID-19 infection and mortality rates.
                    Materials and methods: We analyzed data from a prospective, observational study of the citywide COVID-19 prevention with ivermectin program, which was conducted between July 2020 and December 2020 in Itajaí, Brazil. Study design, institutional review board approval, and analysis of registry data occurred after completion of the program. The program consisted of inviting the entire population of Itajaí to a medical visit to enroll in the program and to compile baseline, personal, demographic, and medical information. In the absence of contraindications, ivermectin was offered as an optional treatment to be taken for two consecutive days every 15 days at a dose of 0.2 mg/kg/day. In cases where a participating citizen of Itajaí became ill with COVID-19, they were recommended not to use ivermectin or any other medication in early outpatient treatment. Clinical outcomes of infection, hospitalization, and death were automatically reported and entered into the registry in real time. Study analysis consisted of comparing ivermectin users with non-users using cohorts of infected patients propensity score-matched by age, sex, and comorbidities. COVID-19 infection and mortality rates were analyzed with and without the use of propensity score matching (PSM).
                    Results: Of the 223,128 citizens of Itajaí considered for the study, a total of 159,561 subjects were included in the analysis: 113,845 (71.3%) regular ivermectin users and 45,716 (23.3%) non-users. Of these, 4,311 ivermectin users were infected, among which 4,197 were from the city of Itajaí (3.7% infection rate), and 3,034 non-users (from Itajaí) were infected (6.6% infection rate), with a 44% reduction in COVID-19 infection rate (risk ratio [RR], 0.56; 95% confidence interval (95% CI), 0.53-0.58; p < 0.0001). Using PSM, two cohorts of 3,034 subjects suffering from COVID-19 infection were compared. The regular use of ivermectin led to a 68% reduction in COVID-19 mortality (25 [0.8%] versus 79 [2.6%] among ivermectin non-users; RR, 0.32; 95% CI, 0.20-0.49; p < 0.0001). When adjusted for residual variables, reduction in mortality rate was 70% (RR, 0.30; 95% CI, 0.19-0.46; p < 0.0001). There was a 56% reduction in hospitalization rate (44 versus 99 hospitalizations among ivermectin users and non-users, respectively; RR, 0.44; 95% CI, 0.31-0.63; p < 0.0001). After adjustment for residual variables, reduction in hospitalization rate was 67% (RR, 0.33; 95% CI, 023-0.66; p < 0.0001).
                    Conclusion: In this large PSM study, regular use of ivermectin as a prophylactic agent was associated with significantly reduced COVID-19 infection, hospitalization, and mortality rates.

                    Keywords: coronavirus; covid-19; ivermectin; prevention; prophylaxis; sars-cov-2.

                    Comment


                    • Shiloh
                      Shiloh commented
                      Editing a comment
                      Source: https://www.cureus.com/articles/1118...ted_modal=true

                      Regular Use of Ivermectin as Prophylaxis for COVID-19 Led Up to a 92% Reduction in COVID-19 Mortality Rate in a Dose-Response Manner: Results of a Prospective Observational Study of a Strictly Controlled Population of 88,012 Subjects
                      Lucy Kerr, Fernando Baldi, Raysildo Lobo, Washington Luiz Assagra, Fernando Carlos Proença, Juan J. Chamie, Jennifer A. Hibberd, Pierre Kory, Flavio A. Cadegiani
                      Published: August 31, 2022 (see history)
                      DOI: 10.7759/cureus.28624


                      Abstract
                      Background

                      We have previously demonstrated that ivermectin used as prophylaxis for coronavirus disease 2019 (COVID-19), irrespective of the regularity, in a strictly controlled citywide program in Southern Brazil (Itajaí, Brazil), was associated with reductions in COVID-19 infection, hospitalization, and mortality rates. In this study, our objective was to determine if the regular use of ivermectin impacted the level of protection from COVID-19 and related outcomes, reinforcing the efficacy of ivermectin through the demonstration of a dose-response effect...

                    • Emily
                      Emily commented
                      Editing a comment
                      Thank you, Tetano. It seems a crime to me that US 'experts' discouraged use of Ivermectin, especially as a prophylactic.

                  • #87
                    January 31, 20222:30 PM EST
                    Last Updated 15 hours ago




                    Ivermectin shows ‘antiviral effect’ against COVID, Japanese company says

                    TOKYO, Jan 31 (Reuters) - Japanese trading and pharmaceuticals company Kowa Co Ltd (7807.T) on Monday said that anti-parasite drug ivermectin showed an "antiviral effect" against Omicron and other coronavirus variants in joint non-clinical research.

                    The company, which has been working with Tokyo's Kitasato University on testing the drug as a potential treatment for COVID-19, did not provide further details. The original Reuters story misstated that ivermectin was "effective" against Omicron in Phase III clinical trials, which are conducted in humans.

                    Clinical trials are ongoing, but promotion of ivermectin as a COVID-19 treatment has generated controversy.

                    more...




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                    • #88
                      bump this

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                      • #89

                        Kowa Co. Ltd. & Kitasato University Pre-Clinical Lab Work: Ivermectin Inhibits Omicron & Other SARS-CoV-2 Variants of Concern

                        Recently TrialSite reported that a Japanese pharmaceutical company, part of a large conglomerate known as Kowa Co. Ltd. Reported they were commencing a large 1000 patient Phase 3 clinical trial investigating the efficacy of ivermectin in COVID-19 patients with mild symptoms. With ambitious plans to end the study by the end of 2021 as reported in the Japanese press and apply for approval in early 2022, TrialSite questioned the feasibility of such an aggressive timeline. Yet now that same company has indicated to mainstream global media, including Reuters, that ivermectin showed an “antiviral effect” against Omicron and other SARS-CoV-2 variants in “joint non-clinical research” in partnership with Kitasato University, an academic medical center in Tokyo with a keen research interest in ivermectin as reported by TrialSite.


                        "Recently TrialSite reported that a Japanese pharmaceutical company, part of a large conglomerate known as Kowa Co. Ltd. Reported they were commencing a large 1000 patient Phase 3 clinical trial investigating the efficacy of ivermectin in COVID-19 patients with mild symptoms. With ambitious plans to end the study by the end of 2021 as reported in the Japanese press and apply for approval in early 2022, TrialSite questioned the feasibility of such an aggressive timeline. Yet now that same company has indicated to mainstream global media, including Reuters, that ivermectin showed an “antiviral effect” against Omicron and other SARS-CoV-2 variants in “joint non-clinical research” in partnership with Kitasato University, an academic medical center in Tokyo with a keen research interest in ivermectin as reported by TrialSite.....


                        IVERMECTIN SHOWED AN ANTIVIRAL EFFECT AGAINST OMICRON AND OTHER CORONAVIRUS VARIANTS IN JOINT NON-CLINICAL RESEARCH

                        "TOKYO, Jan 31 (Reuters) - Japanese trading and pharmaceuticals company Kowa Co Ltd (7807.T) on Monday said that anti-parasite drug ivermectin showed an "antiviral effect" against Omicron and other coronavirus variants in joint non-clinical research.....

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                        • #90
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