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Discussion thread VI - COVID-19 (new coronavirus)

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  • Translation Google

    When will the Covid-19 epidemic end?

    Celine Deluzarche
    Journalist
    ...
    Modified on 23/09/2021
    ...
    Don't expect a drop in virulence

    One of the widespread beliefs is that the virus loses its virulence as the pandemic progresses so as not to kill its host, which is also its transmission vector. Unfortunately, this view does not stand up to the analysis of the facts, for example HIV has become more virulent over time. Likewise, the Delta variant appears to cause more severe forms than the Alpha variant. " In the case of SARS-CoV-2, severe symptoms usually appear after two weeks of infection, but more than 95% of transmissions occur before day 11. In other words, from the perspective of this coronavirus, late (particularly inflammatory) manifestations of virulence do not constitute a loss of transmission opportunities.”, says Samuel Alizon, Director of Research at the CNRS and the IRD.

    Only one disease in history has been eradicated with a vaccine : smallpox , the last known case of which dates back to 1978 in the United Kingdom. “ This eradication has been possible at the cost of relentless vaccination campaigns for decades. In addition, SARS-CoV-2 has an animal reservoir, so it is almost impossible to eradicate the virus, such as the pathogen of plague, for example, ”says Eric Dortenzio, research director at Inserm. In fact, most of the viruses or bacteria responsible for past pandemics are still present today, be it plague, H1N1 or Ebola. Diseases that are still experiencing sporadic epidemic upsurges.“

    Even if the virus were eradicated from the human population, it would continue to circulate in animals and could undergo unexpected mutations.

    According to experts, the safest way to end an epidemic is to slow the spread of the disease and counteract its side effects.
    Pest control and hygiene standards, for example, have helped control plague and cholera . Triple therapies have drastically reduced AIDS mortality . In the case of measles , vaccination makes it possible to reduce the number of contaminations to almost zero, but this requires practically 100% vaccination coverage and the immunity conferred by the vaccine to be sterilizing. that is, it prevents the transmission of the virus. Two conditions that will undoubtedly never be met with Covid-19. " Even if we eradicated the virus in the human population, it would continue to circulate in animals and could undergo unexpected mutations there , ”warns Jean-Claude Manuguerra.
    ...
    Cela fait plus de 20 mois que nous sommes confrontés à la pandémie de Covid-19. Plusieurs fois, on a cru entrevoir la fin de cette terrible épidémie. Mais à chaque fois, une nouvelle vague est...
    "Safety and security don't just happen, they are the result of collective consensus and public investment. We owe our children, the most vulnerable citizens in our society, a life free of violence and fear."
    -Nelson Mandela

    Comment


    • gsgs
      gsgs commented
      Editing a comment
      it is expected that SARS2 gets less virulent since - besides the vaccines - more and more people
      are infected and develope immunity.

      Compare with influenza pandemics.
      Compare with other endemic human coronaviruses.

      These are obviously more related to the current situation than AIDS etc.

  • Originally posted by Pathfinder View Post
    Translation Google

    When will the Covid-19 epidemic end?

    Celine Deluzarche
    Journalist
    ...
    Modified on 23/09/2021
    ...
    Don't expect a drop in virulence

    One of the widespread beliefs is that the virus loses its virulence as the pandemic progresses so as not to kill its host, which is also its transmission vector. Unfortunately, this view does not stand up to the analysis of the facts, for example HIV has become more virulent over time. Likewise, the Delta variant appears to cause more severe forms than the Alpha variant. " In the case of SARS-CoV-2, severe symptoms usually appear after two weeks of infection, but more than 95% of transmissions occur before day 11. In other words, from the perspective of this coronavirus, late (particularly inflammatory) manifestations of virulence do not constitute a loss of transmission opportunities.”, says Samuel Alizon, Director of Research at the CNRS and the IRD.

    Only one disease in history has been eradicated with a vaccine : smallpox , the last known case of which dates back to 1978 in the United Kingdom. “ This eradication has been possible at the cost of relentless vaccination campaigns for decades. In addition, SARS-CoV-2 has an animal reservoir, so it is almost impossible to eradicate the virus, such as the pathogen of plague, for example, ”says Eric Dortenzio, research director at Inserm. In fact, most of the viruses or bacteria responsible for past pandemics are still present today, be it plague, H1N1 or Ebola. Diseases that are still experiencing sporadic epidemic upsurges.“

    Even if the virus were eradicated from the human population, it would continue to circulate in animals and could undergo unexpected mutations.

    According to experts, the safest way to end an epidemic is to slow the spread of the disease and counteract its side effects.
    Pest control and hygiene standards, for example, have helped control plague and cholera . Triple therapies have drastically reduced AIDS mortality . In the case of measles , vaccination makes it possible to reduce the number of contaminations to almost zero, but this requires practically 100% vaccination coverage and the immunity conferred by the vaccine to be sterilizing. that is, it prevents the transmission of the virus. Two conditions that will undoubtedly never be met with Covid-19. " Even if we eradicated the virus in the human population, it would continue to circulate in animals and could undergo unexpected mutations there , ”warns Jean-Claude Manuguerra.
    ...
    https://www.futura-sciences.com/sant...arretee-93646/
    Inserm is with the France National Institute of Health and Medical Research.

    His twitter account:

    Eric D’Ortenzio
    @EricDortenzio
    Follows you
    Médecin, Epidémiologiste
    @agenceANRS

    @Inserm

    @hopitalbichat

    @aphp

    @SamusociaParis
    « L’essentiel est sans cesse menacé par l’insignifiant » René Char


    Doctor, Epidemiologist

    @agenceANRS

    @Inserm

    @hopitalbichat

    @aphp

    @SamusociaParis
    "The essential is ceaselessly threatened by the insignificant" René Char

    Comment


    • gsgs
      gsgs commented
      Editing a comment
      just see the mortality estimates for India.
      4 Million deaths , 0.28% of its population.
      median age=28y , 6%>65 , 3.4%>70
      (USA:median==38.3,15.4%>=65,9.7%>=70)
      Last edited by gsgs; September 27, 2021, 12:30 AM.

    • Emily
      Emily commented
      Editing a comment
      That's sounds very high. This is all that is confirmed. Even more than doubling that would be 1 million. Some have agendas to underestimate, some to overestimate.

      India Coronavirus update with statistics and graphs: total and new cases, deaths per day, mortality and recovery rates, current active cases, recoveries, trends and timeline.

      India
      Deaths:
      448,372

    • gsgs
      gsgs commented
      Editing a comment
      it was a study, that looked reliable to me.
      about +-20% for the 95% confidence interval afair
      similar from another independent source

      here for US-WA : https://www.medrxiv.org/content/10.1....29.21264272v1




  • FluTrackers.com
    @FluTrackers

    13s
    FluTrackers long standing policy on all vaccines:

    Consult your medical practitioner.

    We do not get involved in the "vaccine wars".

    We are a discussion forum.

    We do not offer medical advice.

    We remain the same.

    Comment


    • Noticed these when shopping for a project respirator.
      xhttps://www.homedepot.com/p/3M-Medium-Paint-Project-Respirator-Mask-6211PA1-A/100653900#overlay
      Aug 13, 2021
      I am using the mask to go walking early in...I am using the mask to go walking early in the morning. I had Covid which left me with COPD and I had bronchitis so bad this summer that I had to stay inside all the time. My pulmonary doctor suggested I try the mask in order to get back into a walking routine. It is working!! I am 75 years young and I also use the mask while mowing my lawn.
      by Paula
      Aug 14, 2021
      I have been looking for one of these ever since...I have been looking for one of these ever since the COVID-19 hit the air ways, every place I went they didn't have the respirators that I wanted. now that I have it all I need to do is get these filters for it (If you have these filters let me know 2091 P100 or 7093 P100)? I now wear this resperator when I go any where ast it seals around my nose and mouth 100% and when I breath out it does not blow into my eyes as the cloth mask does. thank you for having it in stock
      by Ranger12



      _____________________________________________

      Ask Congress to Investigate COVID Origins and Government Response to Pandemic.

      i love myself. the quietest. simplest. most powerful. revolution ever. ---- nayyirah waheed

      "...there’s an obvious contest that’s happening between different sectors of the colonial ruling class in this country. And they would, if they could, lump us into their beef, their struggle." ---- Omali Yeshitela, African People’s Socialist Party

      (My posts are not intended as advice or professional assessments of any kind.)
      Never forget Excalibur.

      Comment


      • gsgs
        gsgs commented
        Editing a comment
        use a scissors and a normal mask or hepa-vaccum-cleaner-bag
        I was looking for a respirator that uses these small rectangular hepa-filters



    • Hattip Tetano

      N Engl J Med . Waning Immune Humoral Response to BNT162b2 Covid-19 Vaccine over 6 Months

      N Engl J Med . 2021 Oct 6. doi: 10.1056/NEJMoa2114583. Online ahead of print. Waning Immune Humoral Response to BNT162b2 Covid-19 Vaccine over 6 Months Einav G Levin (https://pubmed.ncbi.nlm.nih.gov/?term=Levin+EG&cauthor_id=34614326) 1 (https://pubmed.ncbi.nlm.nih.gov/34614326/#affiliation-1), Yaniv Lustig


      ...
      Discussion

      In this prospective longitudinal study, we found a significant waning of humoral responses within 6 months after receipt of the second dose of BNT162b2 vaccine in a large cohort of 4868 participants. We observed a continuous decrease in anti-S IgG titers at a relative stable rate within 6 months. The decrease in neutralizing antibody titers was brisk initially, in the period of up to 70 to 80 days, but slowed thereafter. Antibody titers were associated with age, sex, and coexisting conditions. Particularly vulnerable populations with lower neutralizing titers were older men and participants with immunosuppression.

      Published work about many vaccines, such as those against measles, mumps, and rubella, has shown a small decrease each year of 5 to 10% in the neutralizing antibody levels.13,14 We found that a significant and rapid decrease in humoral response to the BNT162b2 vaccine was observed within months after vaccination.
      "Safety and security don't just happen, they are the result of collective consensus and public investment. We owe our children, the most vulnerable citizens in our society, a life free of violence and fear."
      -Nelson Mandela

      Comment


      • sharon sanders
        sharon sanders commented
        Editing a comment
        This is the Pfizer vaccine.

    • Covid immunity through infection or vaccination: Are they equal?
      ...
      Oct. 7, 2021, 3:00 AM CST / Source: Kaiser Health News
      By Arthur Allen, Kaiser Health News
      ...
      The Food and Drug Administration has authorized the use of Covid antibody tests, which can cost about $70, to detect past infections. Some tests can distinguish whether the antibodies came from infections or vaccines. But neither the FDA nor the Centers for Disease Control and Prevention recommend using the tests to assess whether you’re, in fact, immune to Covid. For that, the tests are essentially useless, because there’s no agreement on the amount or the types of antibodies that would signal protection from the disease.

      “We don’t yet have full understanding of what the presence of antibodies tells us about immunity,” said Kelly Wroblewski, the director of infectious diseases at the Association of Public Health Laboratories.
      ...
      CDC spokesperson Kristen Nordlund said in an email that “current evidence” shows wide variation in antibody responses after Covid infection. “We hope to have some additional information on the protectiveness of vaccine immunity compared to natural immunity in the coming weeks,” she said.
      ...
      Evidence is growing that contracting the coronavirus is generally as effective as vaccination at stimulating the immune system to prevent Covid-19.
      "Safety and security don't just happen, they are the result of collective consensus and public investment. We owe our children, the most vulnerable citizens in our society, a life free of violence and fear."
      -Nelson Mandela

      Comment


    • I was in a medical clinic waiting room yesterday. I mentioned this seems a good place to pick up trends before they hit the news. People were sick there when the last wave was building, then all were well the next month as the curve was going down but before the stats really showed a steady improvement. Now a couple of months later, people are still physically well but angry, really angry - about the mandates.

      One of the receptionists was talking with an older man. She said at the last hospital system she worked at, 40-60% of the Covid patients who were coming in sick had been fully vaccinated. Neither she nor the man trusted assurances that the vaccine was preventing serious illnesses. The man wanted more detail about that. He was a veteran who had been sprayed with Agent Orange and he and the receptionist talked about the rotten way the VA is gaslighting veterans about their illnesses. (She had worked there, too.)

      The receptionist said that at the last hospital system she worked at, a lot of medical staff was avoiding the vaccine. But the one she was at currently does mandate it so she got one. She said she was very ill for a full week. She was glad her husband's employer did not mandate it.

      There was also a lot of anger about the pandemic at a lab I was at recently, too. More free floating anger about how messed up the medical system is right now. People seem ready to snap.
      _____________________________________________

      Ask Congress to Investigate COVID Origins and Government Response to Pandemic.

      i love myself. the quietest. simplest. most powerful. revolution ever. ---- nayyirah waheed

      "...there’s an obvious contest that’s happening between different sectors of the colonial ruling class in this country. And they would, if they could, lump us into their beef, their struggle." ---- Omali Yeshitela, African People’s Socialist Party

      (My posts are not intended as advice or professional assessments of any kind.)
      Never forget Excalibur.

      Comment


      • NOT MEDICAL ADVICE - If you have any medical questions, consult your medical practitioner.

        I said I would post about my personal COVID-19 journey since I have been running this site for 15 years and come across many, many expert opinions, data, studies, etc. on a daily basis.

        Tomorrow I am getting the Moderna booster. I really do not like shots. As I said before I get the flu vaccination about 1/2 of the time. I am not someone who rushes to the doctor frequently. I like to find natural items and use those as a first defense.

        The reasons I am getting the booster:

        1) I am very high risk.
        2) I did not have a bad reaction to the first two shots.
        3) I employ a multi-layering strategy and a vaccine is included in that strategy - if possible.

        I have no idea what is going to happen in the future but there will be more waves of some COVID-19 variant. I plan on continuing a restricted life style until further notice. I do watch for trends in my local area so I can increase and decrease my self imposed restrictions. I always carry a mask.

        I know a vaccine booster is not going to "save" me. I have no expectations of this. As I have said many times before it is only ONE TOOL. I will NOT be attending large holiday gatherings inside. I do not expect a vaccine to protect me adequately in those types of situations. The vaccine is a back-up plan to all of the other things that I am doing to avoid contracting the illness. The vaccine is not my first line of defense. I am not taking, or have asked for, any pharma drug for use as a COVID-19 preventative.

        I will report back here if I experience any problems with the booster.

        I agree with Emily above that people are really stressed out. The governments need to back off. No amount of hassle or media promotion is going to make people get any vaccine/medicine/treatment.

        Take of you.

        And thanks for viewing us!


        Comment


        • I just spoke to someone who cancelled my vaccination booster appointment because my local grocery store does not have approval to give the booster from Publix Super Markets, Inc. corporate office despite yesterday's approval. link

          Apparently you can sign up for the booster online but not actually get it.

          Oh well.....

          Comment


          • FDA NEWS RELEASE


            Coronavirus (COVID-19) Update: FDA Takes Additional Actions on the Use of a Booster Dose for COVID-19 Vaccines

            For Immediate Release:October 20, 2021


            Español

            Today, the U.S. Food and Drug Administration took action to expand the use of a booster dose for COVID-19 vaccines in eligible populations. The agency is amending the emergency use authorizations (EUA) for COVID-19 vaccines to allow for the use of a single booster dose as follows:
            • The use of a single booster dose of the Moderna COVID-19 Vaccine that may be administered at least 6 months after completion of the primary series to individuals:
              • 65 years of age and older
              • 18 through 64 years of age at high risk of severe COVID-19
              • 18 through 64 years of age with frequent institutional or occupational exposure to SARS-CoV-2
            • The use of a single booster dose of the Janssen (Johnson and Johnson) COVID-19 Vaccine may be administered at least 2 months after completion of the single-dose primary regimen to individuals 18 years of age and older.
            • The use of each of the available COVID-19 vaccines as a heterologous (or “mix and match”) booster dose in eligible individuals following completion of primary vaccination with a different available COVID-19 vaccine.
            • To clarify that a single booster dose of the Pfizer-BioNTech COVID-19 Vaccine may be administered at least 6 months after completion of the primary series to individuals 18 through 64 years of age with frequent institutional or occupational exposure to SARS-CoV-2.

            “Today’s actions demonstrate our commitment to public health in proactively fighting against the COVID-19 pandemic,” said Acting FDA Commissioner Janet Woodcock, M.D. “As the pandemic continues to impact the country, science has shown that vaccination continues to be the safest and most effective way to prevent COVID-19, including the most serious consequences of the disease, such as hospitalization and death. The available data suggest waning immunity in some populations who are fully vaccinated. The availability of these authorized boosters is important for continued protection against COVID-19 disease.”

            “The amendments to the emergency use authorizations to include a single booster dose in eligible populations are based on the available data and information and follows the input from the members of our advisory committee who were supportive of the use of a booster dose of these vaccines in eligible populations,” said Peter Marks, M.D., Ph.D., director of the FDA’s Center for Biologics Evaluation and Research. “We are also taking action today to include the use of mix and match boosters to address this public health need. We will work to accrue additional data as quickly as possible to further assess the benefits and risks of the use of booster doses in additional populations and plan to update the healthcare community and public with our determination in the coming weeks.”

            Authorization of Moderna COVID-19 Vaccine Booster Dose

            To support the authorization for emergency use of a single booster dose of the Moderna COVID-19 Vaccine, the FDA analyzed immune response data from 149 participants 18 years of age and older from the original clinical studies who received a booster dose at least 6 months after their second dose and compared it to the immune responses of 1,055 study participants after completing their two-dose series. The antibody response of the 149 participants against SARS-CoV-2 virus 29 days after a booster dose of the vaccine demonstrated a booster response.

            The FDA also evaluated an additional analysis from Moderna comparing the rates of COVID-19 accrued during the Delta variant surge during July and August 2021, which suggest that there is a waning of vaccine effectiveness over time.

            Safety was evaluated in 171 participants 18 years of age and older who were followed for an average of approximately six months. The most commonly reported side effects by the clinical trial participants who received the booster dose of the vaccine were pain at the injection site, tiredness, headache, muscle and/or joint pain, chills, swollen lymph nodes in same arm as the injection, nausea and vomiting, and fever. Of note, swollen lymph nodes in the underarm were observed more frequently following the booster dose than after the primary two-dose series.

            Ongoing analyses from the FDA and the Centers for Disease Control and Prevention (CDC) safety surveillance systems have identified increased risks of inflammatory heart conditions, myocarditis and pericarditis, following vaccination with the Moderna COVID-19 vaccine, particularly following the second dose. Typically, onset of symptoms has been a few days following vaccination. The observed risk is higher among males under 40 years of age, particularly males 18 through 24, than among females and older males.

            The Moderna COVID-19 single booster dose is half of the dose that is administered for a primary series dose and is administered at least six months after completion of a primary series of the vaccine.

            Authorization of Janssen (Johnson and Johnson) COVID-19 Vaccine Booster Dose

            The authorization for emergency use of a single booster dose of the Janssen COVID-19 Vaccine is based on the FDA’s evaluation of immune response data in 39 participants from a clinical trial including 24 participants who were 18 through 55 years of age and 15 participants who were 65 years of age and older. The study participants received a booster dose approximately 2 months after their first dose, and the results demonstrated a booster response.

            Overall, approximately 9,000 clinical trial participants have received two doses of Janssen COVID-19 Vaccine administered at least two months apart and of these, approximately 2,700 have had at least two months of safety follow-up after the booster dose. Janssen’s safety analyses from these studies have not identified new safety concerns.

            Earlier analyses from the FDA and CDC safety surveillance systems suggest an increased risk of a serious and rare type of blood clot in combination with low blood platelets following administration of the Janssen COVID-19 vaccine. This serious condition is called thrombocytopenia syndrome (TTS). People who developed TTS after receiving the vaccine had symptoms that began about one to two weeks after vaccination. Reporting of TTS has been highest in females ages 18 through 49 years. In addition, safety surveillance suggests an increased risk of a specific serious neurological disorder called Guillain Barré syndrome, within 42 days following receipt of the Janssen COVID-19 Vaccine.

            Authorization of “Mix and Match” Booster Dose

            Today, the FDA is also authorizing the use of heterologous (or “mix and match”) booster dose for currently available (i.e., FDA-authorized or approved) COVID-19 vaccines. Following a presentation of clinical trial data from the National Institute of Allergy and Infectious Diseases, the Vaccines and Related Biological Products Advisory Committee’s discussion of information submitted for consideration, along with the agency’s evaluation of the available data, the FDA has determined that the known and potential benefits of the use of a single heterologous booster dose outweigh the known and potential risks of their use in eligible populations.

            A single booster dose of any of the available COVID-19 vaccines may be administered as a heterologous booster dose following completion of primary vaccination with a different available COVID-19 vaccine. The eligible population(s) and dosing interval for a heterologous booster dose are the same as those authorized for a booster dose of the vaccine used for primary vaccination.

            For example, Janssen COVID-19 Vaccine recipients 18 years of age and older may receive a single booster dose of Janssen COVID-19 Vaccine, Moderna COVID-19 Vaccine (half dose) or Pfizer-BioNTech COVID-19 Vaccine at least two months after receiving their Janssen COVID-19 Vaccine primary vaccination.

            In another example, Moderna COVID-19 Vaccine and Pfizer-BioNTech COVID-19 vaccine recipients falling into one of the authorized categories for boosters (65 years of age and older, 18 through 64 years of age at high-risk of severe COVID-19, and 18 through 64 years of age with frequent institutional or occupational exposure to SARS-CoV-2) may receive a booster dose of Moderna COVID-19 Vaccine (half dose), Pfizer-BioNTech COVID-19 Vaccine or Janssen COVID-19 Vaccine at least six months after completing their primary vaccination.

            The agency recognizes that health care providers and COVID-19 vaccine recipients will have questions about booster doses. The individual fact sheets for each available vaccine provide relevant information for health care providers and the vaccine recipients. The agency encourages health care providers to also follow the recommendations that will be provided by the CDC following a meeting of their Advisory Committee on Immunization Practices and formal recommendations signed by the CDC director.
            Related Informationhttps://www.fda.gov/news-events/pres...id-19-vaccines
            "Safety and security don't just happen, they are the result of collective consensus and public investment. We owe our children, the most vulnerable citizens in our society, a life free of violence and fear."
            -Nelson Mandela

            Comment


            • Originally posted by sharon sanders View Post
              I just spoke to someone who cancelled my vaccination booster appointment because my local grocery store does not have approval to give the booster from Publix Super Markets, Inc. corporate office despite yesterday's approval. link

              Apparently you can sign up for the booster online but not actually get it.

              Oh well.....
              They are awash in appointment availability at this minute. I could have had another appointment for tomorrow but I chose to move it to Monday. We will see if I am allowed to get it.

              Comment


              • Originally posted by sharon sanders View Post

                They are awash in appointment availability at this minute. I could have had another appointment for tomorrow but I chose to move it to Monday. We will see if I am allowed to get it.
                I'm hopeful you'll be fine until then since you had the Moderna vaccine and you are cautious. There's a new study that shows how short the protection of Pfizer is vs Moderna. It was looking at cancer patients, but control HCW group was pretty much out of gas after 6 months of Pfizer protection.

                There is currently a critical need to determine the efficacy of SARS-CoV-2 vaccination for immunocompromised patients. In this study, we determined the neutralizing antibody response in 160 cancer patients diagnosed with chronic lymphocytic leukemia (CLL), lung cancer, breast cancer, and various non-Hodgkin’s lymphomas (NHL), after they received two doses of mRNA vaccines. Serum from 46 mRNA vaccinated health care workers (HCWs) served as healthy controls. We discovered that (1) cancer patients exhibited reduced neutralizing antibody titer (NT50) compared to HCWs; (2) CLL and NHL patients exhibited the lowest NT50 levels, with 50-60% of them below the detection limit; (3) mean NT50 levels in patients with CLL and NHL was ∼2.6 fold lower than those with solid tumors; and (4) cancer patients who received anti-B cell therapy exhibited significantly reduced NT50 levels. Our results demonstrate an urgent need for novel immunization strategies for cancer patients against SARS-CoV-2, particularly those with hematological cancers and those on anti-B cell therapies. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This study was funded by NCI U54CA260582, NIH R01 AI150473, NIH R01 HL127442-01A1 ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: IRB of OSU gave ethical approval for this work I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable. Yes All data produced in the present study are available upon reasonable request to the authors


                Impaired Neutralizing Antibody Response to COVID-19 mRNA Vaccines in Cancer Patients
                Cong Zeng, John P. Evans, Sarah Reisinger, Jennifer Woyach, Christina Liscynesky, Zeinab El Boghdadly, Mark P. Rubinstein, Karthik Chakravarthy, Linda Saif, Eugene M. Oltz, Richard J. Gumina, Peter G. Shields, Zihai Li, Shan-Lu Liu
                medRxiv 2021.10.20.21265273; doi: https://doi.org/10.1101/2021.10.20.21265273

                "Moderna mRNA-1273 outperformed Pfizer BNT162b2 vaccine in mean NT50 by 2.8-fold for HCWs (p = 0.0053) and 2.1-fold for cancer patients
                (p = 0.0044) (Fig. 1e). This is consistent with our previous findings that Moderna mRNA-1273 vaccinated individuals exhibit higher NT50 levels compared to Pfizer BNT162b212."
                Click image for larger version

Name:	Moderna vs Pfizer.jpg
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                _____________________________________________

                Ask Congress to Investigate COVID Origins and Government Response to Pandemic.

                i love myself. the quietest. simplest. most powerful. revolution ever. ---- nayyirah waheed

                "...there’s an obvious contest that’s happening between different sectors of the colonial ruling class in this country. And they would, if they could, lump us into their beef, their struggle." ---- Omali Yeshitela, African People’s Socialist Party

                (My posts are not intended as advice or professional assessments of any kind.)
                Never forget Excalibur.

                Comment


                • bump this

                  Comment


                  • Originally posted by sharon sanders View Post

                    They are awash in appointment availability at this minute. I could have had another appointment for tomorrow but I chose to move it to Monday. We will see if I am allowed to get it.
                    Publix can argue whether I am immunocomprised or not, but they can not argue that I am 65.



                    CDC Expands Eligibility for COVID-19 Booster Shots

                    Media Statement
                    For Immediate Release: Thursdayday, October 21, 2021
                    Contact: Media Relations
                    (404) 639-3286

                    Today, CDC Director Rochelle P. Walensky, M.D., M.P.H., endorsed the CDC Advisory Committee on Immunization Practices’ (ACIP) recommendation for a booster shot of COVID-19 vaccines in certain populations. The Food and Drug Administration’s (FDA) authorizationexternal icon and CDC’s recommendation for use are important steps forward as we work to stay ahead of the virus and keep Americans safe.

                    For individuals who received a Pfizer-BioNTech or Moderna COVID-19 vaccine, the following groups are eligible for a booster shot at 6 months or more after their initial series:
                    For the nearly 15 million people who got the Johnson & Johnson COVID-19 vaccine, booster shots are also recommended for those who are 18 and older and who were vaccinated two or more months ago.

                    There are now booster recommendations for all three available COVID-19 vaccines in the United States. Eligible individuals may choose which vaccine they receive as a booster dose. Some people may have a preference for the vaccine type that they originally received and others, may prefer to get a different booster. CDC’s recommendations now allow for this type of mix and match dosing for booster shots.

                    Millions of people are newly eligible to receive a booster shot and will benefit from additional protection. However, today’s action should not distract from the critical work of ensuring that unvaccinated people take the first step and get an initial COVID-19 vaccine. More than 65 million Americans remain unvaccinated, leaving themselves – and their children, families, loved ones, and communities– vulnerable.

                    Available data right now show that all three of the COVID-19 vaccines approved or authorized in the United States continue to be highly effective in reducing risk of severe disease, hospitalization, and death, even against the widely circulating Delta variant. Vaccination remains the best way to protect yourself and reduce the spread of the virus and help prevent new variants from emerging.

                    The following is attributable to Dr. Walensky:

                    “These recommendations are another example of our fundamental commitment to protect as many people as possible from COVID-19. The evidence shows that all three COVID-19 vaccines authorized in the United States are safe – as demonstrated by the over 400 million vaccine doses already given. And, they are all highly effective in reducing the risk of severe disease, hospitalization, and death, even in the midst of the widely circulating Delta variant.”


                    Comment


                    • NOT MEDICAL ADVICE. If you have medical questions, consult your medical practitioner.


                      Well, Publix gave me the booster shot! lol

                      I felt nothing. So far no reaction at all. It is the 1/2 dose of Moderna.

                      I really had no choice. I am high risk. I think the best strategy for me is to layer protections.

                      THE VACCINE BOOSTER IS NOT GOING TO SAVE ME. It is only ONE TOOL.

                      As I said before, I use masks, limit my inside exposures, and generally use social distancing as a rule. I also, carry hand sanitizer, and gargle with a mouthwash after outside exposure to people if they come into my comfort sphere. If I need to visit a doctor's office, I have a jazzy pair of goggles I wear. I really don't care how dumb I look to others. In fact, one doctor thanked me.

                      I also listen to my instincts. I was going to shop at the busy grocery store but getting the shot took so long that I felt I had been in the store long enough. About 1/2 of the shoppers did not have any mask on. No one was wearing an N95. I had been in there about 45 minutes so I said - screw it, and left. Nothing solid. Just a feeling.

                      The problem we now have is that all of the millions of people who got the vaccines earlier this year have waning antibodies of some degree. They don't know if they are protected anymore, or not. It remains to be seen what length and strength of immunity COVID survivors have. Do mild cases have any antibodies?

                      In the end, you need to evaluate your personal risk and act on it. People have different ideas of what to do and I respect that.


                      Take care of you.

                      Thank you for following us!

                      Comment


                      • Emily
                        Emily commented
                        Editing a comment
                        Good to hear you were able to get that done and it was 'smooth sailing'!

                      • sharon sanders
                        sharon sanders commented
                        Editing a comment
                        So far nothing really going on. After about 4 hours my arm started to ache where the shot went in. It ached for about 24 hours. Yesterday I felt a little tired like I was coming down with something. Today, all good. Like I said, in my opinion for myself, I feel I really had no choice. I have the responsibility to take care of myself. I can not depend on the whole of society to protect me (which is impossible).

                      • Emily
                        Emily commented
                        Editing a comment
                        It sounds like the half dose was just right for you. At least it seems like they still have protection. Then as a backup as far as approved medical treatments, there are the monoclonal antibodies if available.
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