Announcement

Collapse
No announcement yet.

Discussion thread IV - COVID-19 (new coronavirus)

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • Emily
    commented on 's reply
    Thanks! I like him very much. Here's an earlier video.

  • flatlander
    replied
    Ran across this video today. Interesting discussion on the antibody study from CA that just came out. The interview is done with Dr. Jay Bhattacharya I think his title is Director of Medicine at Stanford (something along this path so I apologize if I got this wrong). He is the one who conducted the trial and is also currently going through data for two other studies, he talks about them in the video as well.

    Leave a comment:


  • Treyfish
    replied
    Originally posted by blacknail View Post
    I am interested to hear anyone's opinion on what Ontario is doing to prevent cases in nursing homes:
    1) Hospital-based teams are going into nursing homes and testing everyone in the home when there is an outbreak (1 positive test). These teams have never worked outside a hospital before and have no knowledge of anything in these nursing homes.
    2) Patients are no longer allowed to be transferred from hospitals to nursing homes. This will create a logjam of LTC patients in hospitals.
    3) Staff may no longer work in more than one nursing home. Presumably, this doesn't apply to the hospital-based teams. This doesn't start until next week.
    Coronavirus exposes systemic cracks in nursing homes
    BY COLIN PERKEL THE CANADIAN PRESS

    POSTED APR 17, 2020 3:36 PM EDT
    The brutal assault of the novel coronavirus on long-term care facilities in Ontario has exposed long-standing, systemic problems in a sector that otherwise seldom receives top-of-mind public attention.

    Those issues range from who cares for the frail and how they do that to government funding levels and wait-lists for one of the 77,000 beds in the province’s 626 long-term care homes.

    To date, more than 100 homes have seen more than 1,200 cases of COVID-19 among residents, accounting for about half the 478 known deaths in the province, according to data from the Integrated Public Health Information System. More than 620 staff have tested positive.


    The incidence among residents and the roughly 80,000 people who look after them is, however, likely higher given relatively low levels of testing and lags in reporting.

    Prime Minister Justin Trudeau noted the grim situation this week.

    “One of the things we’ve seen over the past number of weeks is a far more severe impact on a number of seniors residences and long-term care centres than we had certainly hoped for, or more than we feared,” Trudeau said.

    Experts, however, say the impact of COVID-19 shouldn’t have come as a big surprise given chronic problems in Ontario’s often cash-starved nursing homes _ one-third only meet 1972 standards for space and other requirements _ and the virus’s propensity to strike hardest at older adults and those in poorer health.

    Both factors have been prominent in the rapid and lethal spread through what has in recent years effectively become a $4.2-billion publicly funded system of slow-motion palliative care....https://toronto.citynews.ca/2020/04/...nursing-homes/

    Leave a comment:


  • Treyfish
    replied
    ...Experimental infected cats can transmit SARS-CoV-2 through the air; some cats can cause severe morbidity or even death after infection. The incidence of young cats is obviously more serious than that of older cats. Histopathological observations confirmed that virus-infected cats can cause varying degrees of lung inflammation and intestinal mucosal damage; immunohistochemical studies have found epithelial and olfactory bulb cells of the upper respiratory tract (nasal cavity, palate, tonsils), mucosal gland epithelial cells of the trachea and bronchial mucosa , Intestinal mucosa epithelium and other parts have a large number of viral infections (Figure)...
    .
    The study calls for close monitoring and protection of cats in epidemic areas to avoid contact with the source of infection and prevent them from becoming possible hosts of transmission or storage.....http://www.hvri.ac.cn/xwzh/zhdt/231683.htm

    Leave a comment:


  • blacknail
    replied
    I am interested to hear anyone's opinion on what Ontario is doing to prevent cases in nursing homes:
    1) Hospital-based teams are going into nursing homes and testing everyone in the home when there is an outbreak (1 positive test). These teams have never worked outside a hospital before and have no knowledge of anything in these nursing homes.
    2) Patients are no longer allowed to be transferred from hospitals to nursing homes. This will create a logjam of LTC patients in hospitals.
    3) Staff may no longer work in more than one nursing home. Presumably, this doesn't apply to the hospital-based teams. This doesn't start until next week.

    Leave a comment:


  • JJackson
    commented on 's reply
    Hear! Hear!
    The WHO controlled trials are the ones we should be waiting for and looking at for a definitive answer.
    Not enough countries are participating with thousands of individual trials all giving hints at an answer which are being jumped on in the absence of anything better. If you want to know what works you need lots of studies all following the same protocols using patients at different stages of disease, different age groups, and different doses of the the same drug, or combination of drugs. If these can be performed in different health care systems with different ethnic groups then the data is even better. Too much effort is being wasted on well meaning single studies which are not directly comparable. Statistical significance increase with cohort size!

  • Gert van der Hoek
    replied
    This doctor has some serious questions about the recent study on Remdesivir

    Jeremy Faust MD MS@jeremyfaust

    The time has come to defend science against its own practitioners. Thread!!!!!!!!!! Spoiler: Remdesivir may work, but we won't find that out from a "study" with no fricking control group and with patients who statistically are *not expected to die anyway*.



    Jeremy Faust MD MS@jeremyfaust

    In conclusion, this study is not science. I beg of you, though: Let's insist upon science. Let's get GOOD data. REAL data. Controlled trial data. Then let's give the medications that are proven to work to the patients in whom they have been proven to work on, only.
    “The time has come to defend science against its own practitioners. Thread!!!!!!!!!! Spoiler: Remdesivir may work, but we won't find that out from a "study" with no fricking control group and with patients who statistically are *not expected to die anyway*.”

    Leave a comment:


  • Gert van der Hoek
    replied
    Looking at the situation in Japan: number of cases seems to grow fast: New wave of infections threatens to collapse Japan hospitals .

    This development makes me wonder: people wear masks in Japan, don't they? Without masks it could have been worse? However we must realise: no easy solutions available?

    Leave a comment:


  • Steffi
    replied
    "It is dangerous to approach this virus like any other

    Have found 570 mutations

    K?ri points out, as an example, that a large number of mutations have accumulated in the virus despite the low mutation frequency because it has infected so many, it has been given so many opportunities for mutation. K?ri says that in 1,400 viruses that have been sequenced by deCode (Icelandic genetic analysis), 570 mutations have been found."

    Adjusted Google translation from radionews in Iceland

    https://www.ruv.is/frett/2020/04/17/...og-hverja-adra

    Leave a comment:


  • gsgs
    replied
    I had posted about the podcasts in the German subforum with links.
    Weil viele Hörerinnen und Hörer danach gefragt haben, bieten wir den Podcast auch in schriftlicher Form an. Hier finden Sie alle Skripte zum Herunterladen als PDF.

    also daily Kekule at MDR, but no transkipts.

    hmm, #31 : "reinfection unlikely" but now I just see that WHO doubts that

    Leave a comment:


  • Treyfish
    replied
    WHO Doubts That Antibodies Can Protect Against COVID-19

    Published 17 April 2020 (2 hours 10 minutes ago)
    • Countries like the United Kingdom first relied on the theory until backtracking because of the raising death toll.
    The World Health Organization is not sure whether the presence of antibodies in blood gives full protection against reinfection with the new coronavirus, Mike Ryan, the WHO’s top emergencies expert, told a briefing on Friday.
    Ryan also said that even if antibodies were effective there was little sign that large numbers of people had developed them and were beginning to offer so-called “herd immunity” to the broader population.
    https://www.telesurenglish.net/news/...0417-0014.html

    Leave a comment:


  • Treyfish
    replied
    Vitamin D and the Cytokine Storm


    Last updated: 16 April 2020 22:00EST by Frank Cusimano

    Summary

    As I have posted about VitD before (make sure to see my previous post first), you will know that VitD is important for the immune response. Recently new mediators in the immune response to the coronavirus were identified. One of the molecules, is the same molecule that led to exacerbation of the H1N1 outbreak. VitD and the VitD receptor are important because they have been shown to limit the release of these mediators in the immune response.

    Science

    Previously I mentioned the cytokine storm. After someone becomes infected, the body starts to fight off the virus through the innate immune response utilizing cytokines and nonspecific immune cells. Overtime time your immune system transitions from the innate response to the adaptive immune response utilizing a slower antibody-based approach. In some individuals, during the innate immune response, an overzealous inflammatory response can occur leading to high levels of different cytokines and immune mediators. This, cytokine storm, can lead to the recruitment of additional cells causing widespread tissue damage. In this transition, between the innate and immune system, one cytokine is particularly responsible.

    A recent paper came out showing that in patients with COVID-19, who progressed to severe disease, three cytokines, IP-10, MCP-3, and IL-1ra, were significantly higher .
    http://frankcusimano.com/vitamin-d-c...cytokine-storm

    Leave a comment:


  • Emily
    replied
    Originally posted by gsgs View Post
    subjects from the daily Drosten podcasts translated to English. I extracted texts from the .pdfs , ~1MB can someone translate ? too big for google

    31) Re-infection remains unlikely
    Topics: Transmission while jogging, procedure in the Heinsberg study, representativity of regional studies, accuracy of antibody tests, question of whether virus can be reactivated, problems with samples and laboratory situations Download (170 KB)
    [snip]
    I'm very interested in the jogging/cycling issue. Couldn't find a transcript of the podscast to translate, but I found an article that covers this.

    An unpublished study went viral after a research team warned that respiratory droplets may travel more than 6 feet during exercise. But that's not the whole story.


    Leave a comment:


  • sharon sanders
    replied

    FluTrackers.com
    @FluTrackers
    ?
    11s
    This is "econ prep" weekend #1

    If you lost your job-file for benefits.

    For all: Make a list of your talents & skills.
    List other kinds of jobs you can do if yours is cut.
    List re-fresher courses, license renewals, etc. - get these done.
    Spend $ on basics only. Conserve $.

    Leave a comment:


  • Gert van der Hoek
    replied
    Report: Covid-19 patients recovering quickly after getting experimental drug remdesivir


    By Maggie Fox, CNN



    Updated 0821 GMT (1621 HKT) April 17, 2020


    (CNN)Covid-19 patients who are getting an experimental drug called remdesivir have been recovering quickly, with most going home in days, STAT News reported Thursday after it obtained a video of a conversation about the trial.

    The patients taking part in a clinical trial of the drug have all had severe respiratory symptoms and fever, but were able to leave the hospital after less than a week of treatment, STAT quoted the doctor leading the trial as saying.

    "The best news is that most of our patients have already been discharged, which is great. We've only had two patients perish," Dr. Kathleen Mullane, an infectious disease specialist at the University of Chicago who is leading the clinical trial, said in the video.

    Covid-19 patients who are getting an experimental drug called remdesivir have been recovering quickly, with most going home in days, STAT News reported Thursday after it obtained a video of a conversation about the trial.

    Leave a comment:

Working...
X