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  • Discussion - 2019-nCoV therapeutics

    While it is far too soon to see any disease specific pharmaceuticals or vaccines in fact none of the CoVs infecting humans has a vaccine.
    I am beginning to see reports on drug trials of existing products and products being worked on for SARS that got shelved when the disease failed to reappear.
    I am not qualified to comment on these but if it is an area of interest to you the link below should answer most question. It looks in some detail at the protein structure and conformational changes, the function of key short polypeptides (a few bases), the compounds that show promise, how they interact with the host's protein and how nCov differs from MERS or SARS and how/why that matters. The bottleneck at present is a lack of live virus outside China once these are disseminated will see a flood of papers giving early lab test results for everything they try. I post the link as a reference that can be used to see how it works or why it hasn't.
    http://virological.org/uploads/short...Yw2rfJASAS.pdf

  • #2
    Well - they seem to be sure this doesn't work -

    https://www.thelancet.com/pb-assets/...3620303172.pdf

    "Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury."
    "The only security we have is our ability to adapt."

    Comment


    • #3
      This report provides an excellent review of the methods being used - and signs of severe disease - by someone who clearly is dealing with the nCoV on a daily basis. Well worth reading thoroughly.



      snip.. "Professor Sheng Jifang, director of the Department of Infectious Diseases of Zhejiang University First Hospital and a member of the Zhejiang Provincial Expert Group for the Diagnosis and Treatment of New Coronary Pneumonia, said that specific programs for patients with severe and critical illness are mainly antiviral, nutritional support, and control of cytokine storms. One is to control the cytokine storm, and the other is to inhale high flow oxygen so that there is not a large amount of exudation in the lungs.

      Professor Sheng Jifang introduced that during the test, it was found that the indicators of inflammation of patients with new coronary pneumonia are very high. High indicators can cause human cytokine storms, leading to consequences such as multiple organ failure. Therefore, for critically ill patients, we must properly control the inflammatory factor storm. Some patients' disease progresses rapidly, and it may be mainly a secondary inflammatory factor storm, and the patients are quickly defeated. Because the target organ of the inflammatory factor storm is the lung, the lungs ooze in large quantities and form white lungs. At this time, if there is no corresponding respiratory support treatment, the mortality will increase.

      In addition to controlling the storm of inflammatory factors, another is oxygen therapy. "We found this time that with a high volume of oxygen inhalation, patients could inhale for a day or two or two or three with a special device, and the situation would stabilize."

      Director Sheng Jifang told reporters that the team was closely monitoring the patient's lung CT every day. For patients with new coronary pneumonia, the lung images gradually changed from solid to light, and they gradually became cloud-like, just like the clouds in the sky.

      If it ’s like a dark cloud, then this person is dangerous; if it ’s such a thin tile cloud, it ’s better; if it ’s scattered, it ’s not a big problem. In addition, it depends on the CT of the patient where the affected lung is. Patients with upper and middle lung involvement are better, this patient is better; those with upper, middle, and lower lung involvement, especially those with middle and lower lung involvement, are often heavier. Because our human lungs are large in the lower middle area, oxygen exchange also relies mainly on the lower middle area.
      ..."
      "The only security we have is our ability to adapt."

      Comment


    • #4

      (Original Title: Dean of Jinyintan Hospital: Anti-Medical Clizhi has a promising future, and the clinical effect of Radixivir is obvious)
      Suffering from icy fever, his wife was infected, and he was on the front line of treatment. It was difficult for Zhang Dingyu to get out. However, both for doctors and the general public, the clinical medication and treatment after infection are extremely valuable experiences to be exchanged.

      Jinyintan Hospital is a specialist hospital for infectious diseases in Wuhan. As the director, Zhang Dingyu led the team to conduct an epidemiological investigation on the first 7 patients with unknown pneumonia transferred on December 29, 2019, and collected bronchoalveolar lavage fluid samples for inspection . He also used the anti-AIDS drug clizar for the treatment of severe cases of the new coronavirus pneumonia.

      Recently, the North American Chinese doctor group invited Dean Zhang Dingyu to share the medicine and treatment experience of New Crown. "Mr. Sai" was compiled and slightly edited based on the shared recording. The content has not been reviewed by me.

      abstract:

      1. Kelizhi is the main drug that many first-line doctors like, which can reduce the conversion rate from severe to critical illness.

      The main side effects of Kelizhi are gastrointestinal, nausea, vomiting, and diarrhea; this drug does not respond so strongly in the treatment of AIDS, but patients with neocoronary pneumonia respond very strongly. The other is that the heart rate slows down, so be careful of taking beta blockers, and interact with certain antihypertensive drugs and hypoglycemic drugs.

      People with AIDS who took this medicine had a lower infection rate of new crown pneumonia; more than a thousand cases were tracked, and only 3-5 cases were infected with new crown pneumonia.

      2. The clinical trial of Redecide is still in progress, and it is administered in a ratio of 2: 1, which means that twice as many people in the experiment are given to placebo patients. Although it is double-blind, it can be seen that the obvious effect is to reduce the deterioration of the severe group to the critical group.

      3. Once in critically ill patients, ECMO is rarely extubated (high mortality). Unlike bird flu, the latter can be extubated within 3-5 days.

      4. Plasma therapy: It is effective for critically ill patients, and critically ill patients can maintain a longer blood oxygen concentration.

      5. Some patients found that the throat swab was negative, but the anal swab was still positive.

      6. The course of patients with new coronary pneumonia is from bottom to top, that is, the disease starts from the bottom of the lung and then progresses upward (this may be why there are no upper respiratory symptoms in the early stage), mainly the exudation of the interstitial, and then the consolidation of the lungs.

      Anti-AIDS drug Cleeve has promise, but beware of adverse reactions

      The main thing I want to introduce is the clinical research of medicines that we carry out. After the patient comes, the key is that there is no medicine available.

      The earliest we came into contact with Kelizhi (Lopinavir / Ritonavir) came from Professor Cao Bin of the China-Japan Friendship Hospital. He recommended this product to us. It happens that we are another "anti-AIDS" hospital. We have Cleeve in hand. Later, after our hospital passed the ethical review of the hospital, we initiated a clinical study, which was to compare the use of clef and no clef, because there was no placebo to use, so an open the study.

      So far, nearly 202 cases have been enrolled, two or three cases have "shedded", and only 198 cases have been enrolled. It seems that (Kelizhi) can still reduce mortality and reduce the incidence of critical cases.

      During the study, we collected anus swabs, throat swabs, and blood samples from patients. The collection time was before medication, 5 days and 10 days after medication, and 15 days and 24 days follow-up if the patient was not discharged. Some tests on anal swabs, throat swabs, and blood samples have not yet been started. It is estimated that we will discuss a test plan for these tests tomorrow. We leave these samples mainly to see some changes in viral load and blood antibodies.

      We are quite confident in the use of Climax, although at the beginning we had great hopes for it, and when it was used in the middle, there were some doubts about it because of some adverse reactions. Until now, it feels like it is a very promising medicine against new coronary pneumonia.

      Its main adverse reaction is still gastrointestinal.

      Gastrointestinal reactions, followed by diarrhea, nausea, and vomiting. I don't know why there are so many gastrointestinal reactions in patients with new coronary pneumonia. In fact, this medicine is used in people with AIDS. There are not so many serious gastrointestinal reactions. Although there are some, the patients are basically tolerable. Many patients in this case could not tolerate gastrointestinal reactions.

      Another problem with this medicine is the interactions it causes.

      Some hypoglycemic drugs or beta blockers and other antihypertensive drugs, these drugs cause some blood concentrations to increase (problems). For example, beta blockers increase blood concentrations and slow down heart rate. One of my clerks was eating clef and beta-blockers at the same time. One day my heart rate suddenly dropped to 30-40 times. I was frightened so we were especially vigilant. Some (adverse reactions).

      Be particularly alert to its adverse effects. Adverse reactions include gastrointestinal reactions, and the drug itself can cause heart rate to slow down because it prolongs the QT interval (refers to the time between q wave and t wave in the ECG, which is usually between 0.32 and 0.44s, Greater than 0.44s is the extension of the qt interval) or for other reasons, this section may require special care.

      This is also two weeks after using (Creature), I also reminded on different occasions that our colleagues must be careful when using drugs.

      Less HIV infection

      There is another very important reason for paying attention to clitoris, which is our observation during the epidemic of new crown pneumonia.

      More than 5,000 people in Wuhan are taking anti-AIDS drugs, because Kelly is used as a second-line drug for AIDS, and only more than 600 of these people have taken Kelly.

      We followed up nearly 1,000 HIV-infected people, only 3 to 5 of the 1,000 people. The exact number, I do n’t remember right now, we are still doing it. Among these people, there are currently only 3 to 5 people with HIV infection, at least Less than 10 people have the infection, which is far lower than that of ordinary citizens.

      In addition, the reason I admire Kelizhi is related to my own experience. Because I have a icing disease, after taking Dotti Abalavi, I have not been infected. It happened because my wife was infected, and I had very close contact with her, but I was not infected, so I believe that anti-AIDS drugs may have the effect of inhibiting virus replication.

      We are currently planning to complete the follow-up of more than 5,000 people living with HIV. 1,000 have been done, and after the follow-up work of more than 4,000 HIV-infected people is completed, there will be more detailed evidence to prove the combined use of anti-AIDS, anti-reverse transcriptase inhibitors and protease inhibitors, In fact, it can prevent the replication of the new crown virus.

      Regarding Abidol, we have no experience in using it, but experts are promoting it in the media and admiring this product, so we do n’t have much say in this matter. We don't know much about it.

      Clinical Studies of Redecide

      Redecive has conducted clinical research based on our hospital.

      Our overall target enrollment is about 400 cases of severe cases and 300 cases of mild cases. The current enrollment situation is a 2: 1 ratio of administration, which means that the number of people in the active drug group is slightly larger and the number of people in the placebo group is smaller. However, the clinical doctor can actually feel which medicine is a placebo and which medicine is an active medicine. The overall effect of Radixivir is still relatively obvious, and it can prevent the serious condition from sliding to the critical condition.

      Treatment of severe and critical illness

      The key to current clinical treatment is the critical illness.

      Critically ill so far, there should be no good way. In fact, as far as patients who have been tracheally intubated have rarely been able to successfully extubate. Therefore, the treatment of critical illness is a huge bottleneck. Patients who have been treated with ECMO (Extracorporeal Membrane Oxygenation, commonly known as "Yeke Membrane" and "Artificial Lungs"), they just heard that Professor Peng Zhiyong of Central South Hospital had a patient who had survived, and the others did not see alive Of patients, especially looking forward to a medicine that can prevent slipping to critically ill.

      Kelizhi's words seem to have such a role. We have a few very typical cases, although the evidence is not strong. In a typical case, after using Kelizhi, his entire course was relatively long, and the entire lung was very damaged. Until now, the patient could not escape from oxygen, but could survive. His entire lung injury was very serious, and he is now in the absorption stage of fibrosis. Until now, he can only meet the respiratory exchange under the state of inhaling oxygen. We speculate that if this kind of patient did not use Kelizhi, he would probably have died.

      During the same period, a control patient of ours actually recommended him to use Clevis because of his gastrointestinal reaction, and he did not insist on taking it for only two days. Later, this patient also had an endotracheal intubation and had an artificial lung, but the patient eventually died.

      Regarding the case fatality rate, the overall data (of our hospital) should be higher than the current case fatality rate of Wuhan as a whole, which is more related to the critically ill patients we treat.

      Plasma treatment was started at this time.

      Our longest patient use is only 5 days. A total of 6 patients have been used, 4 of them are critically ill, and two are critically ill. The overall feeling is okay, how to call it okay? One is that the blood oxygen condition has been improved; the other is that the lymphocytes have recovered. Spontaneous symptoms of critically ill patients feel better, and they can also see their mental state better. After the use of recovery plasma in critically ill patients, the situation also improved slightly, that is, the blood oxygen can be maintained when the same breathing parameters are used. Because in fact, many patients who have undergone tracheal intubation, we can see that it is sliding down the abyss step by step, and it is an irreversible process.

      Nucleic acid false negatives may be a problem with sampling

      The standard of rehabilitation is still the national fifth edition of the diagnosis and treatment program, which is twice nucleic acid negative, the patient has no fever for three days, and the symptoms of spontaneous improvement, even if rehabilitation. In these patients, throat swabs were negative after recovery, but anal swabs (us) did not.

      Earlier we did a group of patient's anal swabs and throat swabs. Not for discharged patients, but for discharged patients.

      Those patients are more than ten days after onset, 10 to 15 days, or even 25 days. They are patients after 10 days of hospitalization. At this time we found that his throat swab was negative, but his anal swab was positive.

      Actually very early, when we did nucleic acid and antibody (detection) on January 10 and January 15, so this data should be relatively complete. We also recommend this data to others. Now some experts are beginning to pay attention to the problem of anal swabs. In fact, this phenomenon has existed very early.

      One of our earliest critically ill patients was also a famous patient of ours. After he was transferred, because he had been intubated, we obtained the secretion of his hood and performed a few throat swabs. Nucleic acid in the secretions of the respiratory tract was negative, but his anal swab detected high copy number nucleic acid in his stool. These early tests were conducted in conjunction with the Wuhan Institute of Virology, Chinese Academy of Sciences, which was carried out in another laboratory under Researcher Shi Zhengli and in Researcher Zhou Peng's laboratory.

      Regarding the problem of low PCR positive rate, I think it should be the problem of sampling. This goes back to the problem found in our earliest case.

      In our first group of 7 patients, it was at that time that I learned that the Wuhan CDC had performed nucleic acid tests on these patients with throat swabs, and all of them were negative. At the time, it was Wuhan CDC that had the ability to detect nucleic acids. This nucleic acid was a nucleic acid covering SARS coronavirus at the time, and actually detected SARS coronavirus. If the nucleic acid of SARS coronavirus was detected at that time, it should also be partially positive.

      So I heard at the time that after the nucleic acid was not found in the throat swab, we all performed alveolar lavage on all 7 patients. As a result of alveolar lavage, there were two in Wuhan CDC and one in Wuhan Virus, and two patients were detected at the same time, all of which were positive. Later, the Wuhan Institute of Virology detected another three SARS coronavirus positive.

      A little bit later, other adjusted detection methods used by Wuhan Virus, in fact, all seven patients, that is, all patients were positive for nucleic acid. So I believe that (these false negatives) should be a matter of sampling.

      The lesion starts at the bottom of the lung

      But we can't do all patients with alveolar lavage. The patient's infection, the coronavirus infection, seems to reach the bottom of the lung first, from the end of the lung, the infection in the alveoli, and the infected virus will not reach the upper respiratory tract until it reaches the pharynx, not from top to bottom. . It feels like bottom to top.

      This feeling is also a feeling of Professor Zhao Jianping of Wuhan Tongji Hospital. He also felt the same when he read the radiograph. It feels that these patients in the early stage only had such an infection with a few viruses on the bottom of the lungs, and changed into frost-like glass. Later, they reinfected one by one, and gradually became a so-called white lung. .

      The white lung is different from other exudative changes in the past, it is mainly some interstitial changes, which causes the patient to have a dry cough. If there is no bacterial infection, all patients have a dry cough, it has no sputum, and it does not produce sputum. The change of white lung is mainly a consolidation process caused by some exudates of the interstitial, rather than a change of true exudation.

      This has to go back to the critical patient rescue we just said. In 17 years, our hospital also treated a large number of avian flu patients. The secretions of avian flu patients were very large. After you gave him a membrane lung, many patients could quickly withdraw from the hospital within 3-5 days. After the use of upper membrane lungs, the patient's change is one change a day. It quickly starts to become white lungs, and the lungs will soon become translucent. After the end, they gradually absorb. After 5 days, 6 days, or even a week, many patients will Machine, are able to retract the membrane lung.
      "The only security we have is our ability to adapt."

      Comment


      • #5
        Experiences of a doctor No one expected that my condition would suddenly take a sudden turn at night:



        Difficulty breathing, coughing violently, as if just after running 10,000 meters, the heart will pop out at any time. The heart rate is very slow, and there is an unexplainable chest pain that sweeps the whole body. With a little movement, it hurts.

        I think this should be the second counterattack of the virus.

        I am a doctor. Based on the symptoms, I judged that I had pericardial endocarditis and pericardial effusion. I immediately told the doctor about my condition. I faintly heard the nurse say, "The situation is not so good, people are about to die." I also felt that I couldn't get over that night.

        Thinking that I might never see my husband and daughter again, I struggled to connect with her husband's phone. "I can't do it ..." Upon hearing this, her husband cried with a "wow". With every word I said, my chest pain was about to suffocate. I could only pick a few things that I couldn't be assured of and made a brief explanation with him.

        Soon, the nurse came to draw blood, and the doctor added me medicine. The next day, my test results came out, pericarditis. The doctor said that fortunately I spoke early and gained valuable time for their handling, and my life was saved by myself.[/QUOTE]
        "The only security we have is our ability to adapt."

        Comment


        • #6

          Japan says it is considering the use of an anti-flu drug for the treatment of patients infected with the new coronavirus.

          Health minister Katsunobu Kato spoke to reporters on Saturday.

          He said the health ministry plans to allow the use of the drug if it proves to be effective.

          Kato said Avigan is just one of the drugs they are considering that has been reported overseas to be effective against the new coronavirus.

          He said coordination with local governments and medical associations is necessary to devise a policy that includes specific measures. He said he hopes to have a plan to counter the disease ready by Tuesday.
          "The only security we have is our ability to adapt."

          Comment


          • kiwibird
            kiwibird commented
            Editing a comment
            Also called Favipiravir it is being trialed in China already.

            "Patients with 2019-nCoV are being recruited in randomized trials to evaluate the efficacy of favipiravir plus interferon-α (ChiCTR2000029600) and favipiravir plus baloxavir marboxil (an approved influenza inhibitor targeting the cap-dependent endonuclease) (ChiCTR2000029544)."


            China appears to be expanding its trial of Favipiravir https://www.biospace.com/article/cor...navirus-study/
            "Another study is ongoing of favipiravir compared to AbbVie’s Kaletra, an antiretroviral for HIV. China health officials have recommended broader clinical use of the drug based on 80 coronavirus patients. Zhejiang Hisun Pharmaceutical Co. manufactures favipiravir."

            Interesting to note in the above article Gilead are struggling to recruit patients for their clinical trials in China. There could be several reasons for this.

        • #7
          Ce qui pourrait, un peu ?clair?, ce serait d'entrevoir, pour la population cible ( les plus de 49 ans ), en zone contamin?e, quelles sont les habitudes de vie, dont le r?gime alimentaire qui offrent le plus de r?sultat. Ce me semble, un des aspects du concept de quarantaine, car, s'il est d?montr? que la quarantaine abaisse le taux de survie ...

          Pour les "m?dicaments" , vu les r?gles en place, les r?sultats sur les animaux de laboratoire sont ou ?

          On parle , un peu du microbiome , quand ?

          Bringing together the communities working in the environmental, animal and biomedical microbiome arenas, Microbiome is a forum for presenting the very latest ...

          Comment


          • #8
            I know nothing about Chinese medicine but it has been incorporated extensively in their treatment plans, does anyone know what they have been using and what benefits it is reported to have? Any controlled trials data?

            Comment


            • #9
              The current thinking from what I have gathered is the traditional medicines are mostly beneficial through their anti-inflammatory mechanisms that prevent the cytokinin storm that leads to multiple organ failure and death. It probably helps but doesn't cure.

              Comment


              • JJackson
                JJackson commented
                Editing a comment
                That is about as far as I got in trying to understand what is going on. However what seems to be going on is that disease progression is slow up to a point but can then very rapidly take a turn for the worse. The use of supplementary oxygen and the Chinese traditional medicines at this nexus can change the path of the disease progression for the better. I think it may be important to make sure we have, and understand, these tools in areas, outside China, that do not usually understand how to use them.

            • #10

              Bruce Aylward held a very interesting WHO press conference (link above) re his teams trip to China. The question of TCM (Traditional Chinese Medicine) came up near the end. It seems about 90% of patients are getting some TCM incorporated in their treatment but it has not been evaluated in a clinical trial. Anecdotally it is mainly used to reduce inflammation.
              Remdesivir was also asked about, but there is no answer yet as it is an incomplete double blind trial, he also pointed out that the fall in case numbers in Wuhan is slowing recruitment to the trial as there are not enough patients with the correct trial criteria to enroll.

              Comment


              • #11

                Sources said that led by Academician Jiang Hualiang, Rao Zihe and Academician, the joint research team of the Shanghai Institute of Materia Medica and the Shanghai University of Science and Technology of the Chinese Academy of Sciences found 30 drugs that may be effective against new types of coronavirus, including 12 old drugs such as anti-HIV drugs, and Chinese herbal medicines such as Polygonum cuspidatum and Shandougen are recommended to be considered and paid attention to in the clinical treatment of patients with pneumonitis infected by new coronavirus.
                but..

                As with all medicines - the advice of a Doctor knowledgeable about the medicine should be followed;
                http://www.mychinanews.com/news/n/1/2411398
                "It is a drug that is three points poison" should be used under the guidance of a doctor Academician Zhang also said that Shuanghuanglian (may be the Shandougen in the above post) has always been a better commonly used medicine, and it is also commonly used in clinical practice for clearing heat and detoxifying. However, whether it is an injection or an oral solution, there are some adverse reactions. Although there are not many, there are also some, so it cannot be used blindly. It is best to use it under the guidance of a doctor.



                (Original title: Drink herbal tea and take Chinese medicine to prevent pneumonia? Fake! Guangdong Provincial Hospital of Traditional Chinese Medicine to prevent rumors against pneumonia)
                New coronavirus unidentified pneumonia incidents continue to escalate, and various rumors of prevention and treatment are emerging.
                There have been rumors of Chinese medicine prescriptions preventing pneumonia and drinking a herbal tea to prevent pneumonia. Today, Guangdong Provincial Hospital of Traditional Chinese Medicine has rumored the so-called "medicines".
                In addition, a doctor in a third-tier Chinese medicine hospital in South China told reporters from the 21st Century Business Herald that anti-viral oral solution, isatis root and the like would be useless if they were infected and would not play a preventive role. According to the current situation, the prevention and treatment of unknown pneumonia is the most The effective method is still to wear a mask, wash your hands and ventilate frequently

                Qingfei Paidu Decoction looks as though it is a first call prescription - but it sounds like a process to make it -


                http://www.mychinanews.com/news/n/1/2413596 - about Qinfei Paidu Decoctions.




                They are soliciting for folk remedies here on February 5th, 2020 http://www.mychinanews.com/news/n/11/2412556
                "The only security we have is our ability to adapt."

                Comment


                • #12

                  (Original title: In addition to the results of Li Lanjuan's team, Wuhan also has good news: 5 drugs may be effective)
                  Changjiang Daily-Yangtze River reporter learned from Huazhong University of Science and Technology on February 4 that on February 3, scholars from Wuhan Children's Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology and Tongji Medical College of Huazhong University of Science and Technology joined the First Affiliated Hospital of Xi'an Jiaotong University and Beijing Genomics Research of Chinese Academy of Sciences The Institute and Huawei Cloud Research team announced that they have screened out five antiviral drugs that may be effective for 2019 new coronavirus (2019-nCoV).

                  It is reported that the above-mentioned joint research team targeted ultra-large-scale computer-assisted drugs among 8506 drugs that are on the market or are undergoing clinical trials, targeting multiple target proteins of the new coronavirus in 2019 (including the Mpro protein crystal structure provided by Rao Zi and the academician team of the Chinese Academy of Sciences). Screening work, and achieved the first stage results within a week.

                  The study found that there are five drugs that may be effective against 2019 new coronaviruses: Beclabuvir, Saquinavir, Bictegravir, Lopinavir, and Dolutegravir.

                  The joint research team found that Beclabuvir can not only bind to Mpro protein, but also a potential inhibitor of the new coronavirus RNA-dependent RNA polymerase NSP12 in 2019; Saquinavir can not only bind well to Mpro protein It can also be combined with the S protein of the new 2019 coronavirus, which can prevent the virus from expanding inside and at the same time.

                  It is understood that at present, the joint research team is conducting cytological verification of the above five antiviral drugs and promoting clinical trials of the drugs. The research results released by the joint research team will be made available to biomedical research institutions through Huawei Cloud for the development of antiviral drugs. good news!Looking forward to completing clinical trials and R & D as soon as possible!
                  "The only security we have is our ability to adapt."

                  Comment


                  • #13
                    From the experience of Iran - recommending avoidance of corticosteroid prescriptions;



                    Notice to physicians to avoid prescribing cortins

                    People should avoid any self-treatment

                    Acetaminophen and aspirin affect the immune system

                    Minoo Mohrz, a member of the Ministry of Health's Infectious Diseases Committee in a conversation with Ilena, about the administration of cortins (especially dexamethasone) to patients suspected of having the flu or flu, said: "Normal doctors used the drug for the flu." This is a dangerous prescription. The same risk exists for coronary patients when given dexamethasone.

                    "This is a false prescription," he said. Many doctors routinely prescribe dexamethasone for clients who have symptoms of a fever or a cold. However, this prescription is mistaken even for the common cold.

                    "The matter has been investigated by the National Coronation Committee," Mohrz said. At present, the directive has advised all doctors to avoid prescribing cortins, especially dexamethasone.

                    He added: "Doctors should be trained to avoid prescribing cortins." Of course, this has been part of doctors' training, but some forget it when they come to work.

                    A member of the State Committee on Infectious Diseases of the Ministry of Health said: "In these conditions, people should avoid any self-treatment." Not only dexa, the use of acetaminophen, aspirin and such pills as can be found at home can affect the immune system. Can be. Therefore, aspirin is not recommended as a tablet.

                    Moharz also emphasized: "These cases should not be obsessive in order to prevent patients from following the recommendations and implementation of treatment protocols." Patients may become sensitive and may not allow physicians to receive treatment. If so, their own health or lives are at risk. This is a recommendation to the doctors and it will be completed promptly. So there is no worry for patients.

                    "The best practice in the current situation is to prevent people from taking any medicines because they are unaware of drug interactions," he said. Lack of confidence in the medical advice of physicians is as dangerous as taking these medications. Public awareness and the actions of the Ministry of Health can have a very fruitful result.
                    "The only security we have is our ability to adapt."

                    Comment


                    • #14
                      Originally posted by kiwibird View Post
                      Experiences of a doctor No one expected that my condition would suddenly take a sudden turn at night:



                      Difficulty breathing, coughing violently, as if just after running 10,000 meters, the heart will pop out at any time. The heart rate is very slow, and there is an unexplainable chest pain that sweeps the whole body. With a little movement, it hurts.

                      I think this should be the second counterattack of the virus.

                      I am a doctor. Based on the symptoms, I judged that I had pericardial endocarditis and pericardial effusion. I immediately told the doctor about my condition. I faintly heard the nurse say, "The situation is not so good, people are about to die." I also felt that I couldn't get over that night.

                      Thinking that I might never see my husband and daughter again, I struggled to connect with her husband's phone. "I can't do it ..." Upon hearing this, her husband cried with a "wow". With every word I said, my chest pain was about to suffocate. I could only pick a few things that I couldn't be assured of and made a brief explanation with him.

                      Soon, the nurse came to draw blood, and the doctor added me medicine. The next day, my test results came out, pericarditis. The doctor said that fortunately I spoke early and gained valuable time for their handling, and my life was saved by myself.
                      Kiwi, this is very important and helpful, thank you. If I or someone I know ends up in the hospital, I'll be sure to have an info sheet on this to give to doctors. Better safe than sorry just in case they aren't aware.
                      _____________________________________________

                      Ask Congress to Investigate COVID Origins and Government Response to Pandemic.

                      i love myself. the quietest. simplest. most powerful. revolution ever. ---- nayyirah waheed

                      "...there’s an obvious contest that’s happening between different sectors of the colonial ruling class in this country. And they would, if they could, lump us into their beef, their struggle." ---- Omali Yeshitela, African People’s Socialist Party

                      (My posts are not intended as advice or professional assessments of any kind.)
                      Never forget Excalibur.

                      Comment


                      • #15
                        Thanks Emily. That is very kind of you. Tetano just posted this too - https://flutrackers.com/forum/forum/...e-2019-patient

                        "The only security we have is our ability to adapt."

                        Comment


                        • Emily
                          Emily commented
                          Editing a comment
                          If Tetano were our doctor, we'd be safe!
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