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Discussion: Chinese Academy of Sciences (CAS) in Wuhan has been working with bats and coronavirus for many years - DNA manipulations, cloning....
Bat-mouse bone marrow chimera: a novel animal model for dissecting the uniqueness of the bat immune system
Over the last decade, there has been a wave of high-impact research carried out on cross-species engraftment, such as, the stable reconstitution of human immune system in immunodeficient mice (humanized mouse models)25,26. The development of immunodeficient mice has provided the opportunity to utilize small animal models for the study of many in vivo human-specific immune responses27
....
Unlike the optimised humanized mouse model, our bat-mice were created with crude whole bone marrow cells without any hematopoietic stem cell modification29,55
....
In conclusion, while we are fully aware that bat research is only at its infancy, we are still facing an uphill battle to generate bat-specific research tools, especially antibodies. The novel bat-mouse model generated in this study represents a major technical advancement in recent years and we are confident that this will accelerate many aspects of bat research internationally in the near future....
Maybe the moon would be a safe place to do bat research in wet labs.
"...there’s an obvious contest that’s happening between different sectors of the colonial ruling class in this country. And they would, if they could, lump us into their beef, their struggle." ---- Omali Yeshitela, African People’s Socialist Party
(My posts are not intended as advice or professional assessments of any kind.) Never forget Excalibur.
Europe PMC is an archive of life sciences journal literature.
Origin and evolution of pathogenic coronaviruses. Cui J1,Li F2,
Zheng-Li Shi CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China.
Europe PMC is an archive of life sciences journal literature.
Origin and evolution of pathogenic coronaviruses. Cui J1,Li F2,
Zheng-Li Shi CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China.
Interesting connection.
If you mean the NIH funding, they of course will be blinded to the possibility of a lab accident.
In an exclusive interview, the face of America’s COVID-19 response cautions against the rush for states to reopen, and offers his tips for handling the pandemic's information deluge.
Fauci interview. (Love the super-creepy photo NG did.)
Sure, but what if scientists found the virus outside the lab, brought it back, and then it escaped?
But that means it was in the wild to begin with. That's why I don't get what they're talking about [and] why I don't spend a lot of time going in on this circular argument.
If that is the case then it does matter because if scientists had not gone virus hunting in the wild, we wouldn't have this nightmare now! This particular virus may have never entered human circulation. He knows that. At least there is one scientist who took the time to come up with a plausible scenario for a 'natural', (if there is any such thing anymore), spillover event. It is complex and involves a train ride, but it makes a lot more sense to me than another tired wet market theory.
We have too ample evidence now that the animal that can transport SARS-CoV-2 from point A to point B, and spread it the fastest is a human being. Caged animals of any kind need not apply – and no animal reservoir for the virus has been found, now several months into the investigation. It is not for lack of the Chinese looking - they are far more motivated to understand the genesis of this than anyone. The "pangolin hypothesis’ was based on faulty molecular analysis of sequence similarity, which...
"...there’s an obvious contest that’s happening between different sectors of the colonial ruling class in this country. And they would, if they could, lump us into their beef, their struggle." ---- Omali Yeshitela, African People’s Socialist Party
(My posts are not intended as advice or professional assessments of any kind.) Never forget Excalibur.
On nous dit que le virus ?volue et peut ?voluer vers un moins ou plus, certains aspects. Certaines lign?es cellulaires et animales et pratiques de laboratoires me semblent faites pour tester cela: faire en moins de temps*.
Dans ce cas, on a cr?? le cadre pour que les cycles viraux soient optimis?s, mais on n'agit pas sur ce qui va se produire, sauf d'avoir cr?? le cadre .
La question deviens: quand certains ?crivent qu'il faudrait dans la nature x ann?es, on peut mimer cela en combien de temps en laboratoire ?
j'aimerai disposer de cette donn?e quand je lis certains articles de g?nomique ...
L'autre question est : avoir cr?? le cadre, doit ?tre vu comme une action ou une non action ?
Je dis aussi cela, car quand on cr?e ce genre de cadre, on doit r?guli?rement v?rifier que le produit est identique ? ce que l'on a sem? ?
*cela peut ?tre pr?sent? autrement , bien s?r, disposer de virus, etc ...
One can believe in the train theory and natural recombination of HKU9 with some other viruses SARS-CoV-2- like never seen before (beside RaTG13)
OR
could believe in the conspiracy theory that, beside the RaTG13-like virus and the pangolin virus (RBD), also the furin cleavage site from a HKU9-like virus was mixed in a lab to produce the SARS-CoV-2 chimera. That is not difficult, you can follow the instruction given here by Baric.
Nonlimiting examples of a subgroup 2d coronavirus of this invention include
BtCoV.HKU9.2 (GenBank Accession No. EF065514), BtCoV.HKU9.1 (GenBank Accession
No. NC_009021), BtCoV.HkU9.3 (GenBank Accession No. EF065515), BtCoV.HKU9.4
(GenBank Accession No. EF065516), as well as any other subgroup 2d coronavirus now
known (e.g., as can be found in the GenBank? Database) or later identified, and any
combination thereof.
In addition to receptor binding, proteolytic cleavage of S and potentially other mutations that affect virion and trimer stability may also be important for virus transmissibility in different hosts, and these factors need to be studied further.
@bertrand789 I am so sorry, I do not understand French. I really would like to.
if Kathy ask, I have to do. Here's will be the first time .
We are told that the virus evolves and can evolve towards a less or more, some part. Some cell and animal lines and laboratory practices seem to me made to test this: to do in less time *.
In this case, we created the framework so that the viral cycles are optimized, but we do not act on what will happen, except to have created the framework.
The question becomes: when some write that it would take in nature x years, we can mimic that in how long in the laboratory?
I would like to have this data when I read certain genomics articles ...
The other question is: having created the framework, should be seen as an action or a non-action?
I also say that, because when we create this kind of frame, we must regularly check that the product is identical to what we sowed?
* it can be presented differently, of course, have viruses, etc ...
One can believe in the train theory and natural recombination of HKU9 with some other viruses SARS-CoV-2- like never seen before (beside RaTG13)
OR
could believe in the conspiracy theory that, beside the RaTG13-like virus and the pangolin virus (RBD), also the furin cleavage site from a HKU9-like virus was mixed in a lab to produce the SARS-CoV-2 chimera. That is not difficult, you can follow the instruction given here by Baric.
Nonlimiting examples of a subgroup 2d coronavirus of this invention include
BtCoV.HKU9.2 (GenBank Accession No. EF065514), BtCoV.HKU9.1 (GenBank Accession
No. NC_009021), BtCoV.HkU9.3 (GenBank Accession No. EF065515), BtCoV.HKU9.4
(GenBank Accession No. EF065516), as well as any other subgroup 2d coronavirus now
known (e.g., as can be found in the GenBank? Database) or later identified, and any
combination thereof.
In addition to receptor binding, proteolytic cleavage of S and potentially other mutations that affect virion and trimer stability may also be important for virus transmissibility in different hosts, and these factors need to be studied further.
@bertrand789 I am so sorry, I do not understand French. I really would like to.
It concerns me that the patent suggests the work was done under BSL2 since the Venezuelan Equine Encephalitis Virus was attenuated. What about the 2 human MERS strains and the bat strains? And then this - the collection location is a private home in Chapel Hill with a heavily wooded lot and Mus Musculus is the common house mouse!!! The work was done in mice....could this have escaped?
"...there’s an obvious contest that’s happening between different sectors of the colonial ruling class in this country. And they would, if they could, lump us into their beef, their struggle." ---- Omali Yeshitela, African People’s Socialist Party
(My posts are not intended as advice or professional assessments of any kind.) Never forget Excalibur.
@bertrand789 Thank you so much for your effort to communicate in English!
I have found two articles on possible use of ferrets and tree shrew as infection and transmission animal models for SARS-CoV-2
It is an interesting question to know how faster a virus could mutate during cell passages and in animal models in comparison to natural conditions. I can imagine that the whole process gets faster, but I am not an expert in this field.
@Emily: I am mostly concerned that Fauci says that SARS-CoV-2 can only come from nature, when the virologists have all the tools since years to manipulate this group of viruses almost as they want. He should be aware of this.
Thanks, Kathy. I'll try to look at those. I agree that there appears to be the ability to engineer a virus like SARS2 if someone wanted to. I think I read that the head of the Wuhan lab also was saying nobody is smart enough to do that.
P.S. Watched the J.C. video and thought it was well-done. He's amazing being able to cover technical material in such a clear way while biking like that.
Kathy, thank you, it's a very good bike. Working on this kind of bike, internet and garden, are very important thing ... If you want, they say best thing, ask them to speak about pig in China or every where else...When you speak about pig, you have to be serious...
‘No matter how difficult things are, there will not be a ‘defector’ situation,’ Shi Zhengli says on WeChat.
Chinese virologist at centre of ‘coronavirus came from a laboratory’ claim denies defecting
‘No matter how difficult things are, there will not be a ‘defector’ situation,’ Shi Zhengli says on WeChat
Dismissal comes amid online rumours she and her family were seeking refuge at US embassy in Paris
Sarah Zheng
Published: 4:29pm, 2 May, 2020
Updated: 11:52am, 4 May, 2020
...
“No matter how difficult things are, there will not be a ‘defector’ situation as the rumours have said,” Shi wrote.
“We have not done anything wrong and we continue to have strong faith in science. There must be a day when the clouds part and the sun comes out.”
...
Rumours circulated online claimed Shi and her family had smuggled hundreds of confidential documents out of the country and were seeking refuge at the United States embassy in Paris....
"...there’s an obvious contest that’s happening between different sectors of the colonial ruling class in this country. And they would, if they could, lump us into their beef, their struggle." ---- Omali Yeshitela, African People’s Socialist Party
(My posts are not intended as advice or professional assessments of any kind.) Never forget Excalibur.
Experiments on mice living in more natural habitats can deliver results dramatically different from those in traditional laboratories—with profound implications for biomedical science.
In the summer of 2015, a pioneering band of laboratory mice did something their ancestors hadn’t done for roughly 1,000 generations—they went outside...
The mice are caged outside but it still seems a bit risky if this was done with mice vaccinated or challenged with a virulent live virus.
"...there’s an obvious contest that’s happening between different sectors of the colonial ruling class in this country. And they would, if they could, lump us into their beef, their struggle." ---- Omali Yeshitela, African People’s Socialist Party
(My posts are not intended as advice or professional assessments of any kind.) Never forget Excalibur.
we are moving forward a little. If you wish to recover live viruses in the sewers of NY, ask kathy, they will tell you that they have rat or mouse lines, or, etc. must be kept in a cage in these sewers, for eight days to have a good result?
I have two news: U.S. researcher ‘on verge of making very significant’ coronavirus findings shot dead: reports https://globalnews.ca/news/6910721/c...ad-pittsburgh/ Let’s hope there is no connection between the two facts.
Baric lab modified SARS-CoV-2 to make it infective for mice. https://www.biorxiv.org/content/10.1101/2020.05.06.081497v1 Let’s hope they have a 100% safe lab.
Research Assistant Professor, University of Pittsburgh - Cited by 2,272 - Computational Systems Biology - Biopathway Modeling - Probabilistic Approximation - Modeling Checking - High Performance Computing
"Bing was on the verge of making very significant findings toward understanding the cellular mechanisms that underlie SARS-CoV-2 infection and the cellular basis of the following complications. We will make an effort to complete what he started in an effort to pay homage to his scientific excellence.
His loss will be felt throughout the entire scientific community. Please keep his family, friends, and colleagues in your thoughts. Thank you."
Instead of properly disposing of infected animals by cremation, as the law requires, they sell them on the side to make a little extra cash. Or, in some cases, a lot of extra cash. One Beijing researcher, now in jail, made a million dollars selling his monkeys and rats on the live animal market, where they eventually wound up in someone’s stomach. https://nypost.com/2020/02/22/dont-b...ed-from-a-lab/
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