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H1N1 Tamiflu Resistant Cases -- url Links
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WHO October 16, 2009
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WHO October 22, 2009 http://www.who.int/wer/2009/wer8444/en/index.html
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WHO November 13, 2009
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WHO December 18, 2009
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Here is a preliminary list of H1N1 cases reported from around the world as resistant to Tamiflu roughly sorted by date. First reported url link is generally provided. The number in parentheses following the location is the number of resistant cases. Sequence numbers are provided for some of the early cases. This list is incomplete.
<st1:country-region w:st="on">Japan</st1:country-region>, <st1:city w:st="on"><st1:place w:st="on">Osaka</st1:place></st1:city> (1) (May, 2009) (A/Osaka/180/2009?)
<o:p> </o:p>
<st1:country-region w:st="on">USA</st1:country-region>, <st1:state w:st="on">Hawaii</st1:state> (1) (May 26, 2009) (<st1:country-region w:st="on"><st1:place w:st="on">Singapore</st1:place></st1:country-region>) (A/Singapore/57/2009?)
Denmark, (1) (June 9,<sup> </sup>2009) (A/Denmark/528/2009)
<o:p> </o:p><st1:place w:st="on">Hong Kong</st1:place> (1) (June 11, 2009)
<st1:country-region w:st="on">Canada</st1:country-region>, <st1:state w:st="on"><st1:place w:st="on">Quebec</st1:place></st1:state> (1) (June 26, 2009)
<o:p> </o:p>
<st1:country-region w:st="on">USA</st1:country-region>, <st1:place w:st="on"><st1:city w:st="on">San Francisco</st1:city>, <st1:state w:st="on">California</st1:state></st1:place> (1) (July 3, 2009) (Hong Kong)
<o:p> </o:p>
<st1:place w:st="on"></st1:place><st1:country-region w:st="on">Viet Nam</st1:country-region>, <st1:city w:st="on"><st1:place w:st="on">Hanoi</st1:place></st1:city> (2) (July 9, 2009)
<o:p> </o:p>
<st1:country-region w:st="on"><st1:place w:st="on">Japan</st1:place></st1:country-region>, Yamaguchi (1) (July, 2009?) (A/Yamaguchi/22/2009)
<o:p> </o:p>
<st1:place w:st="on">Hong Kong</st1:place>, Eastern District (1) (July 15, 2009)
<o:p> </o:p>
<st1:country-region w:st="on"></st1:country-region><st1:country-region w:st="on">Japan</st1:country-region>, <st1:city w:st="on"><st1:place w:st="on">Tokushima</st1:place></st1:city> (1) (July 26, 2009)
Hong Kong (1) (July 26, 2009)
<st1:country-region w:st="on">USA</st1:country-region>, <st1:place w:st="on"><st1:state w:st="on">North Carolina</st1:state></st1:place> (2) (July, 2009)
Viet Nam (7) (July, 2009)
Singapore (1) (July 2009)
<o:p> </o:p>
<st1:country-region w:st="on"><st1:place w:st="on">Thailand</st1:place></st1:country-region> (1?) (August 4, 2009)
<o:p> </o:p>
<st1:country-region w:st="on">USA</st1:country-region>, <st1:place w:st="on"><st1:city w:st="on">Seattle</st1:city>, <st1:state w:st="on">Washington</st1:state></st1:place> (2) (August 14, 2009)
Japan, Nagoya (2) (August 16, 2009)
<o:p> </o:p>
<st1:country-region w:st="on">China</st1:country-region>, <st1:place w:st="on"><st1:placename w:st="on">Pingtung</st1:placename> <st1:placetype w:st="on">County</st1:placetype></st1:place> (1) (August 17, 2009)
Japan, Sapporo (1) (August 22, 2009)
<st1:country-region w:st="on">USA</st1:country-region>, <st1:place w:st="on"><st1:state w:st="on">California</st1:state></st1:place>, northern (1) (August 28, 2009)
Canada, Alberta (1) August ??, 2009)
<st1:country-region w:st="on">USA</st1:country-region> , <st1:state w:st="on"><st1:place w:st="on">Texas</st1:place></st1:state> (2) (August, 2009)
<o:p> </o:p>
<st1:place w:st="on"><st1:country-region w:st="on">Japan</st1:country-region></st1:place>, Shiga (1) (August 31, 2009)
Sweden (2) (July August 2009)
Taiwan, (1) (September 1, 2009)
<link rel="File-List" href="file:///C:%5CDOCUME%7E1%5CARS%5CLOCALS%7E1%5CTemp%5Cms ohtml1%5C01%5Cclip_filelist.xml"><!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:PunctuationKerning/> <w:ValidateAgainstSchemas/> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:Compatibility> <w:BreakWrappedTables/> <w:SnapToGridInCell/> <w:WrapTextWithPunct/> <w:UseAsianBreakRules/> <w
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Viet Nam (3) (August, September 2009)
Australia (1) (September 11, 2009)
United Kingdom (2) (September ??, 2009)
Hong Kong (1) (September 14, 2009)
Finland? (1) (September ? 2009)
Canada, Ontario (1) (October, 2009)
Netherlands, Groningen (1) (October, 2009)
Hong Kong (1) (October 7, 2009) (Cumulative Hong Kong total 5)
Japan, Yokahama (1) (October, 2009) (Cumulative Japan total 12)
Japan, Shiga (1) (October 14, 2009) (Cumulative Japan total 13)
USA, Durham North Carolina (4) (mid October, 2009?)
USA, Utah (1) (Fall 2009)
United Kingdom, Wales (5) (early November, 2009?)
Italy, Pavia (1) (November 13, 2009)
http://www.flutrackers.com/forum/showthread.php?t=134052
Scotland (2) (November 16, 2009)
South Korea (1) (November 2009)
South Korea (1) (November 16, 2009)
USA, Tennessee (1) (November 2009)
USA, Delaware, Kent County (1) (November 2009)
USA, Virginia (1) (November ? 2009)
USA, Maryland (1) (November ? 2009)
Spain (2?) (November ? 2009)
USA, Pennsylvania (2) ( November ? 2009)
France (2) (November? 2009)
Spain, Cataluña (1) (December ? 2009) (Cumulative Spain total 3)
Netherlands, Groningen (1) (December 2009) (Cumulative Netherlands total 3)
Netherlands (3) (December 2009) (Cumulative Netherlands total 6)
Japan, Mie Prefecture Yokkaichi City (1) (December 15, 2009)
Germany (2) (December 2009)
Netherlands (5) (December 18, 2009) (Cumulative Netherlands total 11)
Japan, Aichi Prefecture, Nagoya (1) (December 18, 2009)
Brazil?
Argentina?
Corrections and additions welcome.
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WHO October 16, 2009
Systematic surveillance conducted by the Global Influenza Surveillance Network (GISN) including WHO Collaborating Centres (WHOCCs) for reference and research on influenza, continues to detect sporadic incidents of H1N1 pandemic viruses that show resistance to the antiviral oseltamivir. To date, 35 resistant pandemic H1N1 influenza viruses have been detected and characterized worldwide. All of these viruses show the same H275Y mutation that confers resistance to the antiviral oseltamivir, but not to the antiviral zanamivir. Worldwide, more than 10,000 clinical specimens (samples and isolates) of the pandemic H1N1 virus have been tested and found to be sensitive to oseltamivir.
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WHO October 22, 2009 http://www.who.int/wer/2009/wer8444/en/index.html
. . .
Description of cases of oseltamivir resistance
WHO received the first report of an oseltamivir-resistant pandemic (H1N1) 2009 virus in July 2009. As of 22 October 2009, a total of 39 cases had been described, 7 of which are still under investigation. . . .
Description of cases of oseltamivir resistance
WHO received the first report of an oseltamivir-resistant pandemic (H1N1) 2009 virus in July 2009. As of 22 October 2009, a total of 39 cases had been described, 7 of which are still under investigation. . . .
WHO November 13, 2009
To date, 52 oseltamivir resistant pandemic H1N1 influenza viruses have been detected and characterized worldwide. All of these viruses show the same H275Y mutation. All these viruses remain sensitive to zanamivir.
WHO December 18, 2009
Systematic surveillance conducted by the GISN including WHOCCs for Reference and Research on Influenza, continues to identify sporadic incidents of H1N1 pandemic viruses that show resistance to the antiviral oseltamivir. Antiviral susceptibility testing was carried out by WHO CCs and GISN labs on specimens and isolates of pandemic H1N1 viruses from at least 31 countries. 136 cases of oseltamivir resistant pandemic H1N1 have been reported by GISN so far.
Here is a preliminary list of H1N1 cases reported from around the world as resistant to Tamiflu roughly sorted by date. First reported url link is generally provided. The number in parentheses following the location is the number of resistant cases. Sequence numbers are provided for some of the early cases. This list is incomplete.
<st1:country-region w:st="on">Japan</st1:country-region>, <st1:city w:st="on"><st1:place w:st="on">Osaka</st1:place></st1:city> (1) (May, 2009) (A/Osaka/180/2009?)
<o:p> </o:p>
<st1:country-region w:st="on">USA</st1:country-region>, <st1:state w:st="on">Hawaii</st1:state> (1) (May 26, 2009) (<st1:country-region w:st="on"><st1:place w:st="on">Singapore</st1:place></st1:country-region>) (A/Singapore/57/2009?)
Denmark, (1) (June 9,<sup> </sup>2009) (A/Denmark/528/2009)
<o:p> </o:p><st1:place w:st="on">Hong Kong</st1:place> (1) (June 11, 2009)
<st1:country-region w:st="on">Canada</st1:country-region>, <st1:state w:st="on"><st1:place w:st="on">Quebec</st1:place></st1:state> (1) (June 26, 2009)
<o:p> </o:p>
<st1:country-region w:st="on">USA</st1:country-region>, <st1:place w:st="on"><st1:city w:st="on">San Francisco</st1:city>, <st1:state w:st="on">California</st1:state></st1:place> (1) (July 3, 2009) (Hong Kong)
<o:p> </o:p>
<st1:place w:st="on"></st1:place><st1:country-region w:st="on">Viet Nam</st1:country-region>, <st1:city w:st="on"><st1:place w:st="on">Hanoi</st1:place></st1:city> (2) (July 9, 2009)
<o:p> </o:p>
<st1:country-region w:st="on"><st1:place w:st="on">Japan</st1:place></st1:country-region>, Yamaguchi (1) (July, 2009?) (A/Yamaguchi/22/2009)
<o:p> </o:p>
<st1:place w:st="on">Hong Kong</st1:place>, Eastern District (1) (July 15, 2009)
<o:p> </o:p>
<st1:country-region w:st="on"></st1:country-region><st1:country-region w:st="on">Japan</st1:country-region>, <st1:city w:st="on"><st1:place w:st="on">Tokushima</st1:place></st1:city> (1) (July 26, 2009)
Hong Kong (1) (July 26, 2009)
<st1:country-region w:st="on">USA</st1:country-region>, <st1:place w:st="on"><st1:state w:st="on">North Carolina</st1:state></st1:place> (2) (July, 2009)
Viet Nam (7) (July, 2009)
Singapore (1) (July 2009)
<o:p> </o:p>
<st1:country-region w:st="on"><st1:place w:st="on">Thailand</st1:place></st1:country-region> (1?) (August 4, 2009)
<o:p> </o:p>
<st1:country-region w:st="on">USA</st1:country-region>, <st1:place w:st="on"><st1:city w:st="on">Seattle</st1:city>, <st1:state w:st="on">Washington</st1:state></st1:place> (2) (August 14, 2009)
Japan, Nagoya (2) (August 16, 2009)
<o:p> </o:p>
<st1:country-region w:st="on">China</st1:country-region>, <st1:place w:st="on"><st1:placename w:st="on">Pingtung</st1:placename> <st1:placetype w:st="on">County</st1:placetype></st1:place> (1) (August 17, 2009)
Japan, Sapporo (1) (August 22, 2009)
<st1:country-region w:st="on">USA</st1:country-region>, <st1:place w:st="on"><st1:state w:st="on">California</st1:state></st1:place>, northern (1) (August 28, 2009)
Canada, Alberta (1) August ??, 2009)
<st1:country-region w:st="on">USA</st1:country-region> , <st1:state w:st="on"><st1:place w:st="on">Texas</st1:place></st1:state> (2) (August, 2009)
<o:p> </o:p>
<st1:place w:st="on"><st1:country-region w:st="on">Japan</st1:country-region></st1:place>, Shiga (1) (August 31, 2009)
Sweden (2) (July August 2009)
Taiwan, (1) (September 1, 2009)
<link rel="File-List" href="file:///C:%5CDOCUME%7E1%5CARS%5CLOCALS%7E1%5CTemp%5Cms ohtml1%5C01%5Cclip_filelist.xml"><!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:PunctuationKerning/> <w:ValidateAgainstSchemas/> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:Compatibility> <w:BreakWrappedTables/> <w:SnapToGridInCell/> <w:WrapTextWithPunct/> <w:UseAsianBreakRules/> <w
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Viet Nam (3) (August, September 2009)
Australia (1) (September 11, 2009)
United Kingdom (2) (September ??, 2009)
Hong Kong (1) (September 14, 2009)
Finland? (1) (September ? 2009)
Canada, Ontario (1) (October, 2009)
Netherlands, Groningen (1) (October, 2009)
Hong Kong (1) (October 7, 2009) (Cumulative Hong Kong total 5)
Japan, Yokahama (1) (October, 2009) (Cumulative Japan total 12)
Japan, Shiga (1) (October 14, 2009) (Cumulative Japan total 13)
USA, Durham North Carolina (4) (mid October, 2009?)
USA, Utah (1) (Fall 2009)
United Kingdom, Wales (5) (early November, 2009?)
Italy, Pavia (1) (November 13, 2009)
http://www.flutrackers.com/forum/showthread.php?t=134052
Scotland (2) (November 16, 2009)
South Korea (1) (November 2009)
South Korea (1) (November 16, 2009)
USA, Tennessee (1) (November 2009)
USA, Delaware, Kent County (1) (November 2009)
USA, Virginia (1) (November ? 2009)
USA, Maryland (1) (November ? 2009)
Spain (2?) (November ? 2009)
USA, Pennsylvania (2) ( November ? 2009)
France (2) (November? 2009)
Spain, Cataluña (1) (December ? 2009) (Cumulative Spain total 3)
Netherlands, Groningen (1) (December 2009) (Cumulative Netherlands total 3)
Netherlands (3) (December 2009) (Cumulative Netherlands total 6)
Japan, Mie Prefecture Yokkaichi City (1) (December 15, 2009)
Germany (2) (December 2009)
Netherlands (5) (December 18, 2009) (Cumulative Netherlands total 11)
Japan, Aichi Prefecture, Nagoya (1) (December 18, 2009)
Brazil?
Argentina?
Corrections and additions welcome.
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