Re: July San Paolo Sequence Released
Initial description of case:
Girl, 11 years is the first fatal victim of swine influenza in S?o Paulo
Rosanne D'Agostino
From UOL News
In Sao Paulo
A girl of 11 years who died at the end of June is the first fatal victim of avian A (H1N1) in S?o Paulo State, informed the Secretariat of Health of the State this Friday. This is the second death related to the disease in Brazil - the first was a truck driver in Rio Grande do Sul
The girl was hospitalized in a private hospital in Osasco and died on June 30. Two days before the girl felt abdominal pain and vomiting, with symptoms of the disease and was referred to the health unit.
Eventually released and returned with signs of septic shock the day he died because of a cardiorespiratory arrest. The swine flu was confirmed only after death.
The parents of the girl, her brother and a person close also showed signs of disease, but are good. The family is middle class and the children are enrolled in public schools, informed the Secretary of Health, Luiz Roberto Barradas Barata. He said the way the girl is contaminated is under investigation.
"We believe this was not the cause of death, but the flu helped it reduce the immune system, which was already compromised," the secretary said in press conference. He said the child suffered from other problems, including pneumonia, and has had low immunity.
The Secretary said that nothing will change on the policy to combat the disease in S?o Paulo. "The case shows that the state is on alert," he said.
According to relatives, the child does not go abroad nor had contact with patients with symptoms of influenza. On July 1, a brother of the child of 7 years, showed symptoms of flu and was taken to the Emilio Ribas Institute to be hospitalized in isolation. He was discharged with recommendation for home insulation.
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July San Paolo Sequence Released
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Re: July San Paolo Sequence Released
Originally posted by hawkeye View PostThanks Dr. Niman for answering all these questions. I have one additional
With these three changes is the virus obtaining more "human" genes? (re: 1918 being 50/50 pig/human).
It is V252M that is not found in other pandemic swine sequences, but a single change can have a big effect.
From the quote I posted, it sounds like many family members died.
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Re: July San Paolo Sequence Released
Thanks Dr. Niman for answering all these questions. I have one additional
With these three changes is the virus obtaining more "human" genes? (re: 1918 being 50/50 pig/human).
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Re: July San Paolo Sequence Released
Originally posted by Mamabird View PostI'm totally confused. How does V252M in Swine Flu have anything to do with 1918 H1N1? I see no comparison whatsoever with SC, BM, NY, etc. Are we looking at the same sequences?
Thus, positions 249-252 (using H3 numbering) are:
GNLV = wild type H1N1
GNLM = 2009 pandemic H1N1
GNLI = 1918 pandemic H1N1
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Re: July San Paolo Sequence Released
Originally posted by niman View PostThe change (V252M) was present in 1918. The isolates at the bottom of the list (South Carolina, Brevig Mission, and New York) were from dead patients from 1918 (if you click on the link you will see a full description of each isolate).
Seasonal flu (from Peru!), swine, and 1918 are a bad combination.
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Re: July San Paolo Sequence Released
Originally posted by Sally View Post
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Re: July San Paolo Sequence Released
Originally posted by wotan View PostThis was collected almost a month ago. How far has it spread in that time?
Almost a month after the death of the daughter of 11 years (the first fatal victim of swine influenza in S?o Paulo), Paula Nilce Laguna, 40 years, and John Laguna, of 57, spoke in this Saturday for the first time on the subject. The couple confirmed that her daughter never had hantavirus contamination - contracted by rats - who supposedly had weakened his immune system and facilitated the death by influenza virus A (H1N1).
- The challenge that was run by the Department of Health As you can tell that her body was weakened? And now that the examination was negative? Based on what has been said that - Nilce said, presenting the certificate issued by the Institute Adolfo Lutz, showing that the girl had no previous health problems.
Announcing the death of the child, the state Secretary of Health, Luiz Roberto Barradas, said that the victim was suspected hantavirus in childhood. On Friday, in response, the Department of Health said it investigated the possibility that the girl had shaken the immunity of any infection before, but that would be a possibility.
The family Laguna had eight other cases of swine flu confirmed: mother, father, younger brother, three cousins, grandmother and an aunt of the girl. The tragedy led the silence of their parents.
- I have suffered an emotional distress, was not able to speak. It was all played in the media and I was at home taking care of my son with my husband admitted - Nilce bubble.
In the coming days, she, her husband and son will travel to S?o Paulo.
- The confusion took my right to come and go. Some people believe, others not. Confidentiality is a right of the family and I need privacy - Nilce said. <!-- / message -->
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Re: July San Paolo Sequence Released
This report also discusses V252M in influenza B with respect to vaccines
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Re: July San Paolo Sequence Released
Originally posted by theforeigner View PostThanks for trying to explain Niman but I still don´t understand . The thing is I have no clue concerning sequenses ect, so what I am asking for is your bid, in plain english, what the consequeses are? is this a mutation making the H1N1 more virulent?
I belive we are MANY who wish that thise newsreports on sequenses would always be followed by a short explanation, in plain english, because we dont have knowledge about the issue.
Only the HA (codes for the H1 in H1N1) sequence was released, and it has three changes. The travel logs listed show which other sequences in the data base have that change. The search string requires sequence identity on at least one side of the change (there are too many differences between infleunza A and influenza B to pick up shared polymorphisms), so I don't know if V252M in influenza B corresponds to V252M based on influenza A H3 numbering.
However, for the bottom line, V252M may allow the virus to escape from the vaccine being developed, because that change is important in influenza B immunologoical recognition and may be one of the reasons half of the time the influenza B vaccine is a mis-match.
However, apart from the vaccine issue, this change was present in the 1918 pandemic strain (as represented by the three 1918 HA sequences in the database).
The 1918 pandmeic strain combined pieces from H1N1 seasonal flu with H1N1 swine flu, and V252M is found in seasonal flu (2006 isolates from Peru) as well as early (pre-1957) seasonal H1N1. It is also in swine H1N1, so the profile for V252M is not a good one.
The other two changes are in 2009 pandemic isolates, but in different sets of isolates signaling recombination, which is what is used to jumble up the changes to create novel sequences with new properties.
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Re: July San Paolo Sequence Released
This was collected almost a month ago. How far has it spread in that time?
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Re: July San Paolo Sequence Released
Originally posted by Rwilmer View PostSo does this mean that swine has a much higher virulence as a result, Dr. Niman? What is V252M associated with, virulence, transmissability? I was reading up on this a little and found that seasonal flu also has this mutation, is that correct? http://synapse.koreamed.org/Synapse/...jbv-39-125.pdf
Journal of Bacteriology and Virology 2009. Journal of Bacteriology and Virology 2009. Vol. Vol. 39, No. 39, No. 2 p.125 – 136 2 p.125 - 136
DOI 10.4167/jbv.2009.39.2.125 DOI 10.4167/jbv.2009.39.2.125
Genetic Characteristics and Phylogenetic Analysis of Influenza Type B Viruses Isolated from Nasopharyngeal Suction Samples of Korean Patients
Yun Hee Baek, Young Jun Song, Min-Suk Song, Philippe Noriel Q. Yun Hee Baek, Young Jun Song, Min-Suk Song, Philippe Noriel Q. Pascua, Jun Han Lee, Pascua, Jun Han Lee,
Heon-Seok Han, Sung-Il Woo, Seok-Yong Kim and Young-Ki Choi
College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Korea
To investigate the genetic characteristics of human influenza type B viruses circulating in Chungbuk province, Korea, we tested 510 clinical samples of nasopharyngeal suction from pediatric patients diagnosed with respiratory illness between June 2007 and June 2008. Twelve out of thirty-six isolates were identified as type B influenza virus by RT-PCR
Interestingly, genetic characterization of type B viruses isolated in this study revealed that all type B influenza viruses were the Yamagata lineages, a vaccine strains of southern hemisphere during 20072008, type B influenza viruses were the Yamagata lineages, rather than the Victoria lineage of northern hemisphere during 20072008.
Furthermore, there were a total of twelve unique mutations (HA: H40Y, D/G230S, V252M and K272R and NA: P3H, P/T/S42Q, N59S) occurred in our type B isolates. These results suggest that relative high prevalence of type B viruses in Korea during 20072008 season might be due to the wrong vaccine strains selection.
Taken together, the results of this study demonstrate continuous evolutions of human type B viruses by antigenic drift and also highlight the need to closely monitoring of influenza viruses to aid
the early detection of potentially pandemic strains as well as underscore the need for new therapeutics.
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Re: July San Paolo Sequence Released
You still haven't answered my question, what effects will this mutation have on the viruses virulence?
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Re: July San Paolo Sequence Released
Originally posted by Rwilmer View PostDr. Niman, what does this mutation mean? More virulence? Will the vaccine still work?
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