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Clinical Course and Outcomes of Critically Ill Patients With Middle East Respiratory Syndrome Coronavirus Infection - January 28, 2014

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  • Clinical Course and Outcomes of Critically Ill Patients With Middle East Respiratory Syndrome Coronavirus Infection - January 28, 2014

    hat tip @greg_folkers

    Original Research | 28 January 2014

    Clinical Course and Outcomes of Critically Ill Patients With Middle East Respiratory Syndrome Coronavirus Infection FREE ONLINE FIRST
    Yaseen M. Arabi, MD; Ahmed A. Arifi, MD; Hanan H. Balkhy, MD; Hani Najm, MD; Abdulaziz S. Aldawood, MD; Alaa Ghabashi, MD; Hassan Hawa, MD; Adel Alothman, MB; Abdulaziz Khaldi, MD; and Basel Al Raiy, MD
    [+] Article and Author Information
    See Also:
    Medusa's Ugly Head Again: From SARS to MERS-CoV
    Ann Intern Med. Published online 28 January 2014 doi:10.7326/M13-2486 Text Size: A A A
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    Abstract
    Abstract | Editors’ Notes | Methods | Results | Discussion | References
    Background: Since September 2012, 170 confirmed infections with Middle East respiratory syndrome coronavirus (MERS-CoV) have been reported to the World Health Organization, including 72 deaths. Data on critically ill patients with MERS-CoV infection are limited.

    Objective: To describe the critical illness associated with MERS-CoV.

    Design: Case series.

    Setting: 3 intensive care units (ICUs) at 2 tertiary care hospitals in Saudi Arabia.

    Patients: 12 patients with confirmed or probable MERS-CoV infection.

    Measurements: Presenting symptoms, comorbid condition, pulmonary and extrapulmonary manifestations, measures of severity of illness and organ failure, ICU course, and outcome are described, as are the results of surveillance of health care workers (HCWs) and patients with potential exposure.

    Results: Between December 2012 and August 2013, 114 patients were tested for suspected MERS-CoV; of these, 11 ICU patients (10&#37 met the definition of confirmed or probable cases. Three of these patients were part of a healthcare-associated cluster that also included 3 HCWs. One HCW became critically ill and was the 12th patient in this case series. Median Acute Physiology and Chronic Health Evaluation II score was 28 (range, 16-36). All 12 patients had underlying comorbid conditions and presented with acute severe hypoxemic respiratory failure. Most patients (92%) had extrapulmonary manifestations, including shock, acute kidney injury, and thrombocytopenia. Five (42%) were alive at day 90. Of the 520 exposed HCWs, only 4 (1%) were positive.

    Limitation: The sample size was small.

    Conclusion: MERS-CoV causes severe acute hypoxemic respiratory failure and considerable extrapulmonary organ dysfunction and is associated with high mortality. Community-acquired and healthcare-associated MERS-CoV infection occurs in patients with chronic comorbid conditions. The healthcare-associated cluster suggests that human-to-human transmission does occur with unprotected exposure.


    http://annals.org/article.aspx?articleid=1817260

  • #2
    Re: Clinical Course and Outcomes of Critically Ill Patients With Middle East Respiratory Syndrome Coronavirus Infection - January 28, 2014

    [Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]


    Ann Intern Med. 2014 Jan 28. doi: 10.7326/M13-2486. [Epub ahead of print]

    Clinical Course and Outcomes of Critically Ill Patients With Middle East Respiratory Syndrome Coronavirus Infection.

    Arabi YM, Arifi AA, Balkhy HH, Najm H, Aldawood AS, Ghabashi A, Hawa H, Alothman A, Khaldi A, Al Raiy B.


    Abstract

    BACKGROUND:

    Since September 2012, 170 confirmed infections with Middle East respiratory syndrome coronavirus (MERS-CoV) have been reported to the World Health Organization, including 72 deaths. Data on critically ill patients with MERS-CoV infection are limited.


    OBJECTIVE:

    To describe the critical illness associated with MERS-CoV.


    DESIGN:

    Case series.


    SETTING:

    3 intensive care units (ICUs) at 2 tertiary care hospitals in Saudi Arabia.


    PATIENTS:

    12 patients with confirmed or probable MERS-CoV infection.


    MEASUREMENTS:

    Presenting symptoms, comorbid condition, pulmonary and extrapulmonary manifestations, measures of severity of illness and organ failure, ICU course, and outcome are described, as are the results of surveillance of health care workers (HCWs) and patients with potential exposure.


    RESULTS:

    Between December 2012 and August 2013, 114 patients were tested for suspected MERS-CoV; of these, 11 ICU patients (10%) met the definition of confirmed or probable cases. Three of these patients were part of a healthcare-associated cluster that also included 3 HCWs. One HCW became critically ill and was the 12th patient in this case series. Median Acute Physiology and Chronic Health Evaluation II score was 28 (range, 16-36). All 12 patients had underlying comorbid conditions and presented with acute severe hypoxemic respiratory failure. Most patients (92%) had extrapulmonary manifestations, including shock, acute kidney injury, and thrombocytopenia. Five (42%) were alive at day 90. Of the 520 exposed HCWs, only 4 (1%) were positive.


    LIMITATION:

    The sample size was small.


    CONCLUSION:

    MERS-CoV causes severe acute hypoxemic respiratory failure and considerable extrapulmonary organ dysfunction and is associated with high mortality. Community-acquired and healthcare-associated MERS-CoV infection occurs in patients with chronic comorbid conditions. The healthcare-associated cluster suggests that human-to-human transmission does occur with unprotected exposure.


    PRIMARY FUNDING SOURCE:

    None.


    PMID: 24474051 [PubMed - as supplied by publisher]


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