WHO: Recommended composition of influenza virus vaccines for use in the 2016 southern hemisphere influenza season

[tetano]

Recommended composition of influenza virus vaccines for use in the 2016 southern hemisphere influenza season

24 September 2015

It is recommended that trivalent vaccines for use in the 2016 influenza season (southern hemisphere winter) contain the following:

• an A/California/7/2009 (H1N1)pdm09-like virus;
• an A/Hong Kong/4801/2014 (H3N2)-like virus;
• a B/Brisbane/60/2008-like virus.

It is recommended that quadrivalent vaccines containing two influenza B viruses contain the above three viruses and a B/Phuket/3073/2013-like virus.
For more information

• Recommended composition of influenza virus vaccines for use in the 2016 southern hemisphere influenza season - full report
  pdf, 147kb
• Questions and answers - Recommended composition of influenza virus vaccines
  pdf, 130kb

Candidate vaccine viruses and potency testing reagents for development and production of vaccines for use in the southern hemisphere 2016 influenza season

• Influenza A(H1N1)pdm09
  pdf, 246kb
• Influenza A(H3N2)
  pdf, 184kb
• Influenza B Yamagata Lineage
  pdf, 199kb
• Influenza B Victoria Lineage
  pdf, 229kb

http://www.who.int/influenza/vaccines/virus/recommendations/2016_south/en/

[Biological100]

WHO | Antigenic and genetic characteristics of zoonotic influenza viruses and candidate vaccine viruses developed for potential use in human vaccines
24 September 2015

http://www.who.int/entity/influenza/...pdate.pdf?ua=1

[gsgs]

http://www.who.int/influenza/vaccines/virus/recommendations/consultation201509/en/

the 2016 Southern recommendation recommendation paper is out

an A/California/7/2009 (H1N1)pdm09-like virus;
an A/Hong Kong/4801/2014 (H3N2)-like virus;
a B/Brisbane/60/2008-like virus.


http://www.who.int/influenza/vaccine...ation.pdf?ua=1

A(H3N2) viruses collected from February 2015 to August 2015 fell into the phylogenetic
clades 3C.2 and 3C.3. Viruses in sub-clade 3C.2a are now predominant in all regions
of the world. Sub-clade 3C.3a and 3C.3b viruses continued to circulate but represented
the minority of viruses in this reporting period.
Antigenic characteristics of A(H3N2) viruses were assessed with panels of post-infection
ferret antisera in HI and virus neutralization assays. Antigenic characterization of 3C.2a
viruses remained technically challenging because many viruses had low or undetectable
haemagglutination activity and required the use of modified HI and virus neutralization
assays for analysis. Most recent A(H3N2) 3C.2a viruses were well inhibited by ferret
antisera raised against cell-propagated reference
A/Switzerland/9715293/2013 (3C.3a) virus, indicating that 3C.2a and 3C.3a viruses
remain antigenically related. Ferret antisera raised against reference cell-propagated
3C.2a viruses also well inhibited a majority of viruses tested, although inhibition was
somewhat reduced against 3C.3a viruses, indicating that some 3C.2a and 3C.3a
viruses were antigenically distinguishable.
Such changes have been particularly problematic for recent A(H3N2) viruses.
Ferret antisera raised against egg-propagated 3C.2a viruses, including
A/Hong Kong/4801/2014, generally inhibited recently circulating
viruses better than antisera raised to egg-propagated
A/Switzerland/9715293/2013 virus (Table 1).

A/Moldova/111.07/2015 , 3C.2a ,2015-02-10 ,80
A/South Africa/R3777/2015 ,3C.2a ,2015-06-26 ,80
A/South Africa/R3803/2015 ,3C.2a ,2015-06-29 ,80
A/South Africa/R3778/2015 ,3C.2a ,2015-06-29 ,40
A/Iasi/177050/2015 ,3C.3a ,2015-02-04 ,40
A/Behoririka/355/2015 ,3C.3a ,2015-02-04 ,40
A/Manjakaray/612/2015 ,3C.3a ,2015-02-23 ,80
A/Stockholm/19/2015 ,3C.3b ,2015-02-25 ,80
A/Sweden/16/2015 ,3C.3b , 2015/03/05 ,160


80,40 is not so very good



Egg propagation is known to introduce additional changes that may affect antigenicity.