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gsgs

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Join Date: Feb 2006

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PLOS one

April 24, 2013, 01:22 AM

they allow comments

404 Not Found

http://www.plosone.org/article/comments/info%3Adoi%2F10.1371%2Fjournal.pone.0059889

but rarely do I see people commenting, let alone discussion.

This is a bit surprising, given how much effort is put into those papers.
And the lots of "comments" that appear later in the form of "references".

But directly commenting and discussing would be much faster
and more effective - multiple parties could comment and discuss
other than in those papers.

That whole system with grants and papers appears antiquated and
inefficient to me.

I also posted a comment to the recent NEJM-paper, but it didn't appear
(censored ?) -----edit : it shows now, took a while ---------------

tell us about your experiences with paper comments !

Can we make a thread, where copies of comments are collected ?

---------------------------------

Extensive Geographic Mosaicism in Avian Influenza Viruses from Gulls in the Northern Hemisphere

http://www.plosone.org/article/comments/info%3Adoi%2F10.1371%2Fjournal.pone.0020664

Due to limited interaction of migratory birds between Eurasia and America, two independent avian influenza virus (AIV) gene pools have evolved. There is evidence of low frequency reassortment between these regions, which has major implications in global AIV dynamics. Indeed, all currently circulating lineages of the PB1 and PA segments in North America are of Eurasian origin. Large-scale analyses of intercontinental reassortment have shown that viruses isolated from Charadriiformes (gulls, terns, and shorebirds) are the major contributor of these outsider events. To clarify the role of gulls in AIV dynamics, specifically in movement of genes between geographic regions, we have sequenced six gull AIV isolated in Alaska and analyzed these along with 142 other available gull virus sequences. Basic investigations of host species and the locations and times of isolation reveal biases in the available sequence information. Despite these biases, our analyses reveal a high frequency of geographic reassortment in gull viruses isolated in America. This intercontinental gene mixing is not found in the viruses isolated from gulls in Eurasia. This study demonstrates that gulls are important as vectors for geographically reassorted viruses, particularly in America, and that more surveillance effort should be placed on this group of birds.

Canada.Com

http://www.canada.com/health/Worlds+territory+with+challenging+virus+expert+says/8236633/story.html

Just a moment...

http://www.nejm.org/doi/full/10.1056/NEJMoa1304459#t=comments

PLOS Pathogens

http://www.plospathogens.org/article/comments/info%3Adoi%2F10.1371%2Fjournal.ppat.1002077;jsessionid=57EA05A1D7B4CAB7E1C66484E0EE7090.ambra02

A Complete Analysis of HA and NA Genes of Influenza A Viruses

http://www.plosone.org/annotation/listThread.action?root=6699

Background More and more nucleotide sequences of type A influenza virus are available in public databases. Although these sequences have been the focus of many molecular epidemiological and phylogenetic analyses, most studies only deal with a few representative sequences. In this paper, we present a complete analysis of all Haemagglutinin (HA) and Neuraminidase (NA) gene sequences available to allow large scale analyses of the evolution and epidemiology of type A influenza. Methodology/Principal Findings This paper describes an analysis and complete classification of all HA and NA gene sequences available in public databases using multivariate and phylogenetic methods. Conclusions/Significance We analyzed 18975 HA sequences and divided them into 280 subgroups according to multivariate and phylogenetic analyses. Similarly, we divided 11362 NA sequences into 202 subgroups. Compared to previous analyses, this work is more detailed and comprehensive, especially for the bigger datasets. Therefore, it can be used to show the full and complex phylogenetic diversity and provides a framework for studying the molecular evolution and epidemiology of type A influenza virus. For more than 85% of type A influenza HA and NA sequences into GenBank, they are categorized in one unambiguous and unique group. Therefore, our results are a kind of genetic and phylogenetic annotation for influenza HA and NA sequences. In addition, sequences of swine influenza viruses come from 56 HA and 45 NA subgroups. Most of these subgroups also include viruses from other hosts indicating cross species transmission of the viruses between pigs and other hosts. Furthermore, the phylogenetic diversity of swine influenza viruses from Eurasia is greater than that of North American strains and both of them are becoming more diverse. Apart from viruses from human, pigs, birds and horses, viruses from other species show very low phylogenetic diversity. This might indicate that viruses have not become established in these species. Based on current evidence, there is no simple pattern of inter-hemisphere transmission of avian influenza viruses and it appears to happen sporadically. However, for H6 subtype avian influenza viruses, such transmissions might have happened very frequently and multiple and bidirectional transmission events might exist.

PLOS Pathogens

http://www.plospathogens.org/article/comments/info%3Adoi%2F10.1371%2Fjournal.ppat.1003176

404 Not Found

http://www.plosone.org/annotation/listThread.action?inReplyTo=info:doi/10.1371/annotation/49e2e5af-27d3-46d7-903f-4df59807c977&root=info:doi/10.1371/annotation/49e2e5af-27d3-46d7-903f-4df59807c977

Last edited by gsgs; April 24, 2013, 01:28 AM. Reason: added links

I'm interested in expert panflu damage estimates
my current links: http://bit.ly/hFI7H ILI-charts: http://bit.ly/CcRgT
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