By Helen Branswell @HelenBranswell
January 24, 2019
If you’ve ever gotten a flu shot — and then, later that season, gotten the flu — you were more than likely, and rightly, miffed. Your doctor might have explained that the problem was possibly that the influenza vaccine wasn’t well matched that year to the strains people coughed and sneezed in your direction.
But increasingly influenza researchers are offering another explanation: The problem, at least partly, could be you.
A growing body of evidence suggests that sometimes our immune systems simply don’t follow the instructions a vaccine tries to give them — that is, make antibodies to fight a particular H3N2 or H1N1 virus. The reason? We all have flu baggage that shapes the way our immune systems respond to both infections and vaccines.

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https://www.statnews.com/2019/01/24/...cines-fail-us/