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Study: Birth prevalence of microcephaly in India (WHO, Zika Open, February 23, 2016)

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  • Study: Birth prevalence of microcephaly in India (WHO, Zika Open, February 23, 2016)

    Publication: Bulletin of the World Health Organization; Type: Research in emergencies
    Article ID: BLT.16.172080


    DISCLAIMER

    This paper was submitted to the Bulletin of the World Health Organization posted to the Zika
    open site according to the protocol for public health emergencies for international concern as
    described in Christopher Dye et al. (http://dx.doi.org/10.2471/BLT.16.170860).
    The information herein is available for unrestricted use, distribution and reproduction in any
    medium, provided that the original work is properly cited as indicated by the Creative Commons
    Attribution 3.0 Intergovernmental Organizations licence (CC BY IGO 3.0).

    RECOMMENDED CITATION
    Bhide P, Kar A. Birth prevalence of microcephaly in India. [Submitted]. Bull World Health
    Organ E-pub: 23 Feb 2016. doi: http://dx.doi.org/10.2471/BLT.16.172080

    Birth prevalence of microcephaly in India

    Prajkta Bhidea
    & Anita Kara
    a
    Interdisciplinary School of Health Sciences, Savitribai Phule Pune University, Ganeshkhind, Pune 411
    007, India.
    Correspondence to Anita Kar (email: akar@unipune.ac.in).
    (Submitted 19 February 2016 – Published online 23 February 2016)

    Publication: Bulletin of the World Health Organization; Type: Research in emergencies
    Article ID: BLT.16.172080

    Abstract

    Objective: To derive a baseline estimate of the birth prevalence of congenital microcephaly in
    India, in the background of the suspected association with Zika virus infection
    Methods: We searched Pubmed and Scopus for identifying studies reporting prevalence of
    microcephaly affected births in India. Only nine studies reported data on newborns with
    microcephaly among both live and stillbirths. Pooled prevalence was estimated in Review
    Manager (version 5.3) software using the inverse variance method.

    Findings: The pooled prevalence rate of newborns with microcephaly was 2.30 per 10 000 births
    (95% CI 1.82 – 2.78) among 97 155 births reported by the nine studies.
    Conclusion: The microcephaly prevalence rate was found to be similar to that reported by the
    European surveillance of congenital anomalies. The need for clear case definition of
    microcephaly was identified in order to limit over-reporting of cases due to diagnosis based on
    subjective evaluations.

    ...
    Full text:
    http://www.who.int/bulletin/online_first/16-172080.pdf

    http://www.who.int/bulletin/online_first/zika_open/en/
    "Safety and security don't just happen, they are the result of collective consensus and public investment. We owe our children, the most vulnerable citizens in our society, a life free of violence and fear."
    -Nelson Mandela
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