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  • Australian Sequences

    Now that everyone's attention is turning to the Southern Hemisphere to track Swine Flu, and since WHO went to Level 6 partially as a result of the significant increase of infections in Australia, wouldn't it be peachy if we had some complete genetic sequences from that country? Missing PA, PB2 and NS on those few samples that are available at GISAID and Gen Bank.

    Something current would be useful as well. If this virus becomes Tamiflu resistant or acquires E627K in PB2 segment, it is likely to happen in Australia during their flu season.

    Am I asking too much to share this with the rest of the world?

  • #2
    Re: Australian Sequences

    Are PA, PB2 and NS the ones you watch most closely?

    I've been wondering why they release some segments first over others?

    Darwin/2001 was collected on 5-29 and published at GenBank on 6-5. Is that timely?

    It ought to be mandatory to share vital information in a timely manner during pandemic times.
    The salvage of human life ought to be placed above barter and exchange ~ Louis Harris, 1918

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    • #3
      Re: Australian Sequences

      Originally posted by mixin View Post
      Are PA, PB2 and NS the ones you watch most closely?
      I'm interested in monitoring the NA segment for Tamiflu resistance, the PB1, PB2 and NS segments to determine if the pathogenicity of the virus appears to be changing.

      It is also nice to have all the segments from the host virus to determine which variant it is relative to all the other Swine Flu isolates available at Gen Bank. Somce indication of direction of spread is sometimes discernable from such an analysis as well.

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      • #4
        Re: Australian Sequences

        Originally posted by Mamabird View Post
        .........., wouldn't it be peachy if we had some complete genetic sequences from that country? Missing PA, PB2 and NS on those few samples that are available at GISAID and Gen Bank.

        Something current would be useful as well. If this virus becomes Tamiflu resistant or acquires E627K in PB2 segment, it is likely to happen in Australia during their flu season.

        Am I asking too much to share this with the rest of the world?
        Exactly who is responsible for release of the Australian sequences?

        Do you have names, addresses, emails, etc., so that readers can express their concerns directly to the responsible party?

        .
        "The next major advancement in the health of American people will be determined by what the individual is willing to do for himself"-- John Knowles, Former President of the Rockefeller Foundation

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        • #5
          Re: Australian Sequences

          Tis interesting that both Australia and NZ, are only releasing HA, some NA, & some M1 & M2 on A/H1N1 since 3/01/09. Are the 3 NAs from Australia listed below a normal number of samples for the known number of cases?

          ACR08497 465 Human NA H1N1 Australia 2009/05/07 Influenza A virus (A/Brisbane/17/2009(H1N1))
          ACR78157 467 Human NA H1N1 Australia 2009/05/19 Influenza A virus (A/Victoria/2001/2009(H1N1))
          ACR78161 465 Human NA H1N1 Australia 2009/05/26 Influenza A virus (A/Perth/29/2009(H1N1))
          Going back a few years, the last year that PB2, PB1-F2, NS1, NS2 were released for Australia and New Zealand was in 2005. What changed after that?

          .
          "The next major advancement in the health of American people will be determined by what the individual is willing to do for himself"-- John Knowles, Former President of the Rockefeller Foundation

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