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why are the Dobson 1927 sequences so similar to the 1902 sequences ?
That's quite unusual and surprising, still I couldn't find any comment
about it.
In other areas of science such things would be discussed heavily...,
so what's going on in Biosciences ? Same with the Canadian swine,
noone except HenryN commenting on it.
A/fowl/Dobson/1927(H7N7)
A/chicken/Brescia/1902(H7N7)
also a A/FPV/Dobson/'Dutch'/(H7N7)
(FPV:fowl plague virus, later found to be influenza A)
Brescia is Italy, Dobson I found in North Carolina,USA (also in NZ?) but why "Dutch" ?
was the 1902 virus conserved and released in 1927 ? How did it come to Dobson ?
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Israel, A. (1980). Genotypic and phenotypic characterization of a mammalian cell-adapted mutant of fowl plague virus (FPV). Journal of General Virology 51(Pt. 1): 33-44. ISSN: 0022-1317.
NAL Call Number: QR360.A1J6
Abstract: A mammalian cell-adapted mutant of the Dobson strain of fowl plague virus (FPV-B) was characterized. Genetic analyses of recombinants between a ts mutant of this virus and either the non-adapted Dobson strain or the Rostock strain of FPV showed that the gene coding for the P3 protein of the adapted Dobson strain was sufficient to enable any recombinant to grow in L cells. The abortive cycle of wild-type Dobson strain (FPV+) was compared to the productive cycle of the mutant. By using 100 p.f.u./cell, no quantitative difference could be detected in infected L cells between polypeptides and cRNAs induced by FPV+ and FPV-B. However, the maturation of virions at the plasma membrane did not proceed correctly. At a lower m.o.i. the amounts of virus polypeptides decreased with the m.o.i. This decrease was not the same for all polypeptides and cRNA segments: HA, M and NA and their mRNAs decreased to a greater extent than the others. These results are discussed in relation to a possible biological activity of polypeptide P3.
Descriptors: genes viral, influenza A virus avian genetics, virus replication, avian growth and development, avian metabolism, L cells cell line, mice, mutation, RNA viral biosynthesis, recombination, genetic, viral proteins biosynthesis.
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JSTOR: Avian Influenza: Historical AspectsThe demonstration that "fowl plague" was caused by one of the few .... the virus was introduced into the country but Dobson suggested that disease may have ...
genbank gives Dobson as in USA, but also A/FPV/Dobson and the 'Dutch' from "United Kingdom"
this also says Dobson is in UK
http://www.biohealthbase.org/GSearch...ator=influenza
That's quite unusual and surprising, still I couldn't find any comment
about it.
In other areas of science such things would be discussed heavily...,
so what's going on in Biosciences ? Same with the Canadian swine,
noone except HenryN commenting on it.
A/fowl/Dobson/1927(H7N7)
A/chicken/Brescia/1902(H7N7)
also a A/FPV/Dobson/'Dutch'/(H7N7)
(FPV:fowl plague virus, later found to be influenza A)
Brescia is Italy, Dobson I found in North Carolina,USA (also in NZ?) but why "Dutch" ?
was the 1902 virus conserved and released in 1927 ? How did it come to Dobson ?
--------------------------------------
Israel, A. (1980). Genotypic and phenotypic characterization of a mammalian cell-adapted mutant of fowl plague virus (FPV). Journal of General Virology 51(Pt. 1): 33-44. ISSN: 0022-1317.
NAL Call Number: QR360.A1J6
Abstract: A mammalian cell-adapted mutant of the Dobson strain of fowl plague virus (FPV-B) was characterized. Genetic analyses of recombinants between a ts mutant of this virus and either the non-adapted Dobson strain or the Rostock strain of FPV showed that the gene coding for the P3 protein of the adapted Dobson strain was sufficient to enable any recombinant to grow in L cells. The abortive cycle of wild-type Dobson strain (FPV+) was compared to the productive cycle of the mutant. By using 100 p.f.u./cell, no quantitative difference could be detected in infected L cells between polypeptides and cRNAs induced by FPV+ and FPV-B. However, the maturation of virions at the plasma membrane did not proceed correctly. At a lower m.o.i. the amounts of virus polypeptides decreased with the m.o.i. This decrease was not the same for all polypeptides and cRNA segments: HA, M and NA and their mRNAs decreased to a greater extent than the others. These results are discussed in relation to a possible biological activity of polypeptide P3.
Descriptors: genes viral, influenza A virus avian genetics, virus replication, avian growth and development, avian metabolism, L cells cell line, mice, mutation, RNA viral biosynthesis, recombination, genetic, viral proteins biosynthesis.
----------------------------------------
JSTOR: Avian Influenza: Historical AspectsThe demonstration that "fowl plague" was caused by one of the few .... the virus was introduced into the country but Dobson suggested that disease may have ...
genbank gives Dobson as in USA, but also A/FPV/Dobson and the 'Dutch' from "United Kingdom"
this also says Dobson is in UK
http://www.biohealthbase.org/GSearch...ator=influenza
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