Source: http://www.022net.com/2013/5-22/496639322663664.html
Fudan University researchers found that the new H7N9 virus originated
2013-5-22 16:53:22 Source: Xinmin Evening News
Published:
According to collected a subtype H7 HA (ie H7N3 virus) from Hangzhou, China, ducks, and collected seven N9 subtypes of NA (ie H7N9 virus) is derived from the Korean poultry, for the novel H7N9 subtype avian influenza virus origin, and foreign academic experts generally believe that birds from China and South Korea.
Fudan University School of Public Health of young teachers Xiong Chenglong, Zhang Zhijie and other advanced bioinformatics tools for this H7N9 avian influenza virus gene research and analysis, the first time that the two most important viral proteins HA and NA poultry originated in Eastern China or wild birds, rather than the previous foreign academic experts think of as "birds were from China and South Korea."
This finding is accurate infer the origin and evolution of influenza viruses law provides the necessary theoretical basis for further study of both influenza virus spread and popular rule, early warning of influenza spread, and then take positive and effective prevention and control strategies has important guiding significance . Related papers have recently been published online in the field of infectious diseases renowned international journal "Clinical Infectious Diseases" (Clinical Infectious Diseases).
In February this year, China's eastern region, emerging series of influenza-like illness; March 31, the National Health and Family Planning Commission informed pathogen infection is confirmed for the new H7N9 subtype of avian influenza virus. According to collected a subtype H7 HA (ie H7N3 virus) from Hangzhou, China, ducks, and collected seven N9 subtypes of NA (ie H7N9 virus) is derived from the Korean poultry, for the novel H7N9 subtype avian influenza virus origin, and foreign academic experts generally believe that birds from China and South Korea.
Xiong Chenglong, Zhang Zhijie HA academic research teams identify sources reported, but there are objections to the NA sources. Based on the "gene nucleotide constitutes the most basic unit of protein amino acids constitute the basic unit of the nucleotide and amino acid homology analysis, will be able to figure out the origin and evolution of the virus" considerations, the research team analysis of the global sharing of influenza database (including representative strains of this pathogenic H7N9 viruses and 2006 to 2011 seven South Korean strain NA subtype strains) greater than 1000 nucleotides in length gene sequences of 321 N9 NA sequences by This deduced amino acid sequence of the corresponding protein. Finally confirmed: H7N9 avian influenza virus of the most important proteins HA (N9 gene) from China Jiangsu Hongze Lake Baikal Teal (ie H11N9 virus strain). The most important results of this study based on one of the nucleotide and protein from the amino acid sequence similarity search results to see, H7N9 virus, the most important and H11N9 virus NA protein nucleotide and amino acid sequence similarity level, 7 is much higher than the strain NA subtype isolates Korean similarity. Meanwhile, Hangzhou is the H7N3 virus isolation, it is also the second major epidemic of an influenza pandemic, Hongze Lake is China's fourth largest freshwater lake, is the main habitat for waterfowl, is one of H11N9 virus separately. They believe that this flu initially occurred, H7 HA subtypes contribute to and H11N9 virus isolates separately are located in China's eastern regions, from the geographical point of view, the possibility of restructuring occurring strains also much higher than Korea strains. (Reporter correspondent Shi Jie Sun Kwok-kan)
Fudan University researchers found that the new H7N9 virus originated
2013-5-22 16:53:22 Source: Xinmin Evening News
Published:
According to collected a subtype H7 HA (ie H7N3 virus) from Hangzhou, China, ducks, and collected seven N9 subtypes of NA (ie H7N9 virus) is derived from the Korean poultry, for the novel H7N9 subtype avian influenza virus origin, and foreign academic experts generally believe that birds from China and South Korea.
Fudan University School of Public Health of young teachers Xiong Chenglong, Zhang Zhijie and other advanced bioinformatics tools for this H7N9 avian influenza virus gene research and analysis, the first time that the two most important viral proteins HA and NA poultry originated in Eastern China or wild birds, rather than the previous foreign academic experts think of as "birds were from China and South Korea."
This finding is accurate infer the origin and evolution of influenza viruses law provides the necessary theoretical basis for further study of both influenza virus spread and popular rule, early warning of influenza spread, and then take positive and effective prevention and control strategies has important guiding significance . Related papers have recently been published online in the field of infectious diseases renowned international journal "Clinical Infectious Diseases" (Clinical Infectious Diseases).
In February this year, China's eastern region, emerging series of influenza-like illness; March 31, the National Health and Family Planning Commission informed pathogen infection is confirmed for the new H7N9 subtype of avian influenza virus. According to collected a subtype H7 HA (ie H7N3 virus) from Hangzhou, China, ducks, and collected seven N9 subtypes of NA (ie H7N9 virus) is derived from the Korean poultry, for the novel H7N9 subtype avian influenza virus origin, and foreign academic experts generally believe that birds from China and South Korea.
Xiong Chenglong, Zhang Zhijie HA academic research teams identify sources reported, but there are objections to the NA sources. Based on the "gene nucleotide constitutes the most basic unit of protein amino acids constitute the basic unit of the nucleotide and amino acid homology analysis, will be able to figure out the origin and evolution of the virus" considerations, the research team analysis of the global sharing of influenza database (including representative strains of this pathogenic H7N9 viruses and 2006 to 2011 seven South Korean strain NA subtype strains) greater than 1000 nucleotides in length gene sequences of 321 N9 NA sequences by This deduced amino acid sequence of the corresponding protein. Finally confirmed: H7N9 avian influenza virus of the most important proteins HA (N9 gene) from China Jiangsu Hongze Lake Baikal Teal (ie H11N9 virus strain). The most important results of this study based on one of the nucleotide and protein from the amino acid sequence similarity search results to see, H7N9 virus, the most important and H11N9 virus NA protein nucleotide and amino acid sequence similarity level, 7 is much higher than the strain NA subtype isolates Korean similarity. Meanwhile, Hangzhou is the H7N3 virus isolation, it is also the second major epidemic of an influenza pandemic, Hongze Lake is China's fourth largest freshwater lake, is the main habitat for waterfowl, is one of H11N9 virus separately. They believe that this flu initially occurred, H7 HA subtypes contribute to and H11N9 virus isolates separately are located in China's eastern regions, from the geographical point of view, the possibility of restructuring occurring strains also much higher than Korea strains. (Reporter correspondent Shi Jie Sun Kwok-kan)
Comment