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ChinaJiangsu1_2011_01_04 published today at GISAID carries an HA from swine around the world from 2007 to 2009.
Oddly enough, a significant group of the currently emerging polymorphisms onto the human pH1N1 background in the UK Severe Wave are also found on this Chinese swine-basedHA.
The WHO Chinese National Influenza Center in Beijing deposited a full set of gene segment sequences on <strong><span style="color: #783f04;">2011-01-14</span></strong> from a 3M sample taken in Jiangsu Province during the first week of the year.
Preliminary review shows that <strong><span style="color: #783f04;">ChinaJiangsu1_3M_2011_01_04</span></strong> carries a novel <strong><span style="color: #274e13;">Hemagglutinin</span></strong> most closely related to <strong><span style="color: #660000;">late decade swine</span></strong> from Asia. The captivating factor is that this <strong><span style="color: #660000;">swine-like</span></strong> <strong><span style="color: #274e13;">HA</span></strong> also demonstrates <strong><span style="color: #783f04;">homology at least 25 recent genetic acquisitions </span></strong>into the human <strong><span style="color: #4c1130;">pH1N1</span></strong> reservoir related to the <strong><span style="color: #783f04;">UK Severe Wave</span></strong> and associated sequences on the <strong><span style="color: #783f04;">highly divergent</span></strong> and <strong><span style="color: #660000;">hyper-zoonotic</span></strong> emerging sub-clades.
<strong><span style="color: #783f04;">GeneWurx</span></strong> has prepared a spreadsheet for collaboration <a href="http://genewurx.com/data/GeneWurx_Novel_HA_Jiangsu1_3M_2011_01_04_v0.xls" target="_blank">detailing the preliminarily</a> recognised <strong><span style="color: #4c1130;">pH1N1</span></strong> homologies to this most recent sequence in the database, <strong><span style="color: #783f04;">ChinaJiangsu1_3M_2011_01_04</span></strong>. Several additional matches are not yet vetted for the spreadsheet, including <strong><span style="color: blue;">syn338G, syn343G, syn346G, syn353G</span></strong> and <strong><span style="color: blue;">syn363G</span></strong>. Each must be investigated as <strong><span style="color: #783f04;">variant silent codings</span></strong> to changes in <strong><span style="color: #4c1130;">pH1N1</span></strong> at the same amino acid position.
Notification of a human case of swine influenza in Jiangsu
Hong Kong (HKSAR) - The Centre for Health Protection (CHP) of the Department of Health received notification from the Ministry of Health (MoH) concerning a confirmed human case of European avian-like H1N1 swine influenza A in Jiangsu Province.
A CHP spokesman said the patient was a three-year-old boy living in Jiangsu, who had chronic renal disease and on long term steroid treatment. He developed symptoms on December 31 last year.
Laboratory tests on the patient's specimen by the Chinese Centre for Diseases Control and Prevention yielded positive result for European avian-like H1N1 swine influenza A.
His close contacts were asymptomatic.
The CHP is maintaining close liaison with the MoH.
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