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Gs has posted some great tables with the RBD changes seen in all the pamdemic flu sequences plus many (or most/all) of the Influenza A's.
Here's a brief explanation of his tables:
The letters are the amino acids located in the RBD; notice in the example the number/series of his little dots coincide with the letters. This dot example is Ekaterinburg/01/2009 and this one has an "R" at the Q226 position that just recently was discussed in connection with D225.
Y GVTAA WIT HPPTTSEQQSLYQ EIAARPKVRGQAGRM
. ..... ... ............. ..........R....
I was curious about the GVTAA domain since I hadn't seen that discussed much; so I put together this example of how the amino acids change when there are changes in the nucleotides:
GVTAA ggt gta acg gca gca no mutations
GATAA ggt gca acg gca gca Wisconsin/629-D02064
GITAA ggt ata acg gca gca Indiana/09
GVTTA ggt gta acg aca gca Wisconsin/629-D01445
GVTVA ggt gta acg gta gca New York/12 EPI179286
GVTXA ggt gta acg gya gca New York/12 EPI177391
Here's the list of the amino acids and the nucleotides:
A: GCT, GCC, GCA, GCG (Alanine,Ala)
R: CGT, CGC, CGA, CGG, AGA, AGG (Arginine,Arg)
N: AAT, AAC (Asparagine,Asn)
D: GAT, GAC (Aspartic Acid,Asp)
C: TGT, TGC (Cysteine,Cys)
E: GAA, GAG (GlutamicAcid,Glu)
Q: CAA, CAG (Glutamine,Gln)
G: GGT, GGC, GGA, GGG (Glycine,Gly)
H: CAT, CAC (Histidine,His)
I: ATT, ATC, ATA (Isoleucine,Ile)
L: TTA, TTG, CTT, CTC, CTA, CTG (Leucine,Leu)
K: AAA, AAG (Lysine,Lys)
M: ATG (Methionine,Met)
F: TTT, TTC (Phenylalanine,Phe)
P: CCT, CCC, CCA, CCG (Proline,Pro)
S: TCT, TCC, TCA, TCG, AGT, AGC (Serine,Ser)
T: ACT, ACC, ACA, ACG (Threonine,Thr)
W: TGG (Tryptophan,Trp)
Y: TAT, TAC (Tyrosine,Tyr)
V: GTT, GTC, GTA, GTG (Valine,Val)
STOP,Sto,}: TAG, TGA, TAA
hydrophobic: GAVLIMFWP
hydrophilic: STCYNQ,DE,KRH
Here's a brief explanation of his tables:
The letters are the amino acids located in the RBD; notice in the example the number/series of his little dots coincide with the letters. This dot example is Ekaterinburg/01/2009 and this one has an "R" at the Q226 position that just recently was discussed in connection with D225.
Y GVTAA WIT HPPTTSEQQSLYQ EIAARPKVRGQAGRM
. ..... ... ............. ..........R....
I was curious about the GVTAA domain since I hadn't seen that discussed much; so I put together this example of how the amino acids change when there are changes in the nucleotides:
GVTAA ggt gta acg gca gca no mutations
GATAA ggt gca acg gca gca Wisconsin/629-D02064
GITAA ggt ata acg gca gca Indiana/09
GVTTA ggt gta acg aca gca Wisconsin/629-D01445
GVTVA ggt gta acg gta gca New York/12 EPI179286
GVTXA ggt gta acg gya gca New York/12 EPI177391
Here's the list of the amino acids and the nucleotides:
A: GCT, GCC, GCA, GCG (Alanine,Ala)
R: CGT, CGC, CGA, CGG, AGA, AGG (Arginine,Arg)
N: AAT, AAC (Asparagine,Asn)
D: GAT, GAC (Aspartic Acid,Asp)
C: TGT, TGC (Cysteine,Cys)
E: GAA, GAG (GlutamicAcid,Glu)
Q: CAA, CAG (Glutamine,Gln)
G: GGT, GGC, GGA, GGG (Glycine,Gly)
H: CAT, CAC (Histidine,His)
I: ATT, ATC, ATA (Isoleucine,Ile)
L: TTA, TTG, CTT, CTC, CTA, CTG (Leucine,Leu)
K: AAA, AAG (Lysine,Lys)
M: ATG (Methionine,Met)
F: TTT, TTC (Phenylalanine,Phe)
P: CCT, CCC, CCA, CCG (Proline,Pro)
S: TCT, TCC, TCA, TCG, AGT, AGC (Serine,Ser)
T: ACT, ACC, ACA, ACG (Threonine,Thr)
W: TGG (Tryptophan,Trp)
Y: TAT, TAC (Tyrosine,Tyr)
V: GTT, GTC, GTA, GTG (Valine,Val)
STOP,Sto,}: TAG, TGA, TAA
hydrophobic: GAVLIMFWP
hydrophilic: STCYNQ,DE,KRH
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