Analysis - pH1N1 Drug Resistance & Vaccine Escape: CDC Fall 2013

[NS1]

pH1N1 Drug Resistance & Vaccine Escape
CDC Fall 2013

Map - Active and Detailed

<div style="text-align: center;">
<hr style="width: 30%;" />29 Cases over 32 Sequences<hr style="width: 30%;" /></div>
Introduction

In the week from 2013-11-22 to 2013-11-29, the&nbsp;<span style="color: #783f04;"><b>United States CDC</b></span>&nbsp;released or updated a total of 32&nbsp;<b><span style="color: #632423; font-family: &quot;Trebuchet MS&quot;;">pH1N1</span></b>&nbsp;sequences at&nbsp;<strong>GISAID&nbsp;</strong>on 29 human cases<strong>&nbsp;</strong>sampled from July 2013 to November 2013. Geographic surveillance includes&nbsp;<b>America,</b>&nbsp;<b>India&nbsp;</b>and<b>&nbsp;Hong Kong.&nbsp;</b>

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Read the Open-Access, Full-Text
Investigational Analytic
including Genetic Details

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Re: Analysis - pH1N1 Drug Resistance &amp; Vaccine Escape: CDC Fall 2013

pH1N1
Data Sparsity
Winter 2013

2014-01-20-21:30
Close of Business, Atlanta

Situations depicting severe influenza are being reported around the United States, including a family cluster of Acute Respiratory Distress Syndrome (ARDS) leading to death in both the husband and wife [FT#216770] and another cluster where a seasoned paramedic died just before his wife was placed into a medically-induced coma for pH1N1 treatment [FT#216065].

Due to a lack of integral information on the severity of the current influenza season, a small group of volunteer citizens has pursued the quantification of fatality rates in hospitalised cases around America [FT#217093]. Although Drug Resistance and Vaccine Escape continue to be reported around the country, including the US Navy [FT#519276], a single sequence has been deposited covering the geography during 2013 Weeks 51 and 52 for American states that are experiencing severe and fatal pH1N1 Influenza.

Requests for Information have been made for several US States, including Texas and California, beginning in December and concentrating on four contiguous calendar weeks.

RFI for Season Week

• 2013-Week51
• 2013-Week52
• 2014-Week01
• 2014-Week02

Sparsity Profiles by State

• [FT#215743] - Alaska
• [FT#216511] - Arkansas
• [FT#216286] - Georgia
• [FT#217101] - Ohio
• [FT#217262] - Tennessee
• [FT#216295] - Texas
• [FT#215491] - Utah

A publication quiescence has now extended for 8 weeks on experimental mechanisms that successfully demonstrated polymorphisms correlated to deep lung involvement in humans.

These matters of clinical, genetic and statistical data sparsity are relevant and operative in the policy-making and medical delivery arenas during this pathogenic surge.

[NS1]

Re: Analysis - pH1N1 Drug Resistance &amp; Vaccine Escape: CDC Fall 2013

pH1N1
Risk Factor Assessment
Data Sparsity
Winter 2013

2014-01-24-19:00
Close of Business Week, Atlanta

By the Close of Business today, 2014-01-24, the United States CDC added no sequences relevant to the current High Intensity outbreaks in America. Although local death rates are doubling over records set last season, a single sequence has been deposited covering the geography during 2013 Weeks 51 and 52 for American states that are experiencing severe and fatal pH1N1 Influenza.

One sequence is not much of a shield against a virus placing vaccinated, healthy young adults into Critical Care units around the nation. While young mothers and fathers fall dead in their own homes in front of their children, the very information that may have saved them was being actively withheld.