Announcement

**NS1** · January 22, 2014, 07:23 PM

Re: pH1N1 Drug Resistant Low Reactor CDC Fall 2013

pH1N1
Data Sparsity
Winter 2013

2014-01-22-19:00
Close of Business, Atlanta

Due to a lack of integral information on the severity of the current influenza season, a small group of volunteer citizens has pursued the quantification of fatality rates in hospitalised cases around America [FT#217093]. Although Drug Resistance and Vaccine Escape continue to be reported around the country, including the US Navy [FT#519276], a single sequence has been deposited covering the geography during 2013 Weeks 51 and 52 for American states that are experiencing severe and fatal pH1N1 Influenza.

Requests for Information have been made for several US States, including Texas and California, beginning in December and concentrating on four contiguous calendar weeks.

RFI for Season Week

2013-Week51
2013-Week52
2014-Week01
2014-Week02

A total of 6 sequences are on file from US Public Health sources to describe the entire state of Texas for the current season (s2013) and the inter-season (i2013). Genetic change counts are featured for each sequence's Hemagglutinin (HA) and Neuraminidase (NA) segment.

HA 22 & NA 15 for Texas 2013-December
HA 21 & NA 18 for Texas 2013-November
HA 23 & NA 16 for Texas 2013-October
HA 21 & NA 14 for Texas 2013-September
HA 26 & NA 13 for Texas 2013-August
HA 23 & NA 16 for Texas 2013-July

pH1N1 decision-making using facts requires deploying current data and making rational projections based on knowledge of the viral genetics and the clinical presentation / progression.

One sequence is not enough to build an understanding of the virus placing vaccinated, healthy young adults into Critical Care units around the nation.

**NS1** · January 28, 2014, 03:24 AM

Re: pH1N1 Drug Resistant Low Reactor CDC Fall 2013

pH1N1 Drug Resistant Vaccine Escape
Winter 2013
Risk Factor Assessment
Data Sparsity

2014-01-27-19:00
Close of Business, Atlanta

GISAID Delta
2014-01-27

In a seemingly endless charade, the United States CDC at Close of Business today, 2014-01-27, added a partial set of segments for 1 new US sequence that was backdated and interspersed as having been published on 2014-01-09*. The new sequence was given a backdated and arbitrary delta modification date indicated as 2014-01-17.

New Hampshire C3 with No HA Segment*

No new egg based passage strategies are in this surreptitious deposit, nor is even one sequence found covering an area of America experiencing High Intensity influenza during the time period of clinical and epidemiological escalation.

Sparsity Profiles by State

[FT#215743] - Alaska
[FT#216511] - Arkansas
[FT#216286] - Georgia
[FT#217101] - Ohio
[FT#217262] - Tennessee
[FT#216295] - Texas
[FT#215491] - Utah

A publication quiescence has now extended beyond 8 weeks on experimental mechanisms that successfully demonstrated polymorphisms correlated to deep lung involvement in humans.

These matters of clinical, genetic and statistical data sparsity are relevant and operative in the policy-making and medical delivery arenas during this pathogenic surge.

GISAID
Audit Standards

Evidently, the larger organisations understand how to exploit the lack of basic audit standards within GISAID systems.

The existing ability for organisations to slip in current work that they backdate with an arbitrary earlier date creates openings for data abuse, research anomaly and the potential for misleading the public using fraudulent research. No argument needs to made that point-in-time snapshots, factual observations, are the bedrock of scientific progress.

We have made multiple, detailed enquiries to GISAID concerning these significant holes that prevent basic research conclusions and comprehensive analyses. No revision schedule has been communicated; although, system revision is occurring with various updates installed from time to time without announcement, including recent system software mods during this peak season of usage.

Perhaps system design is outsourced to the larger member organisations who have a vested interest in preserving the security flaws and the backdoors around audits? The lack of transparency, this hegemony of monopoly, generally points to a foundational, even philosophical, error in the institution's experimental basis . . . intentions notwithstanding.

* New Sequence on 2014-01-27 by Close of Business with a backdated arbitrary Submission Date of 2014-01-09

Announcement

pH1N1 Drug Resistant Low Reactor CDC Fall 2013

pH1N1 Drug Resistant Low Reactor CDC Fall 2013

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