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Analysis - HA 166N Polymorphism Potential on pH1N1 Cross-Clade Background with Both 188T and 189T

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  • Analysis - HA 166N Polymorphism Potential on pH1N1 Cross-Clade Background with Both 188T and 189T

    hat tip NS1 at Genewurx

    2013-02-26

    HA 166N Polymorphism Potential on pH1N1 Cross-Clade Background with Both 188T and 189T


    Current trending indicates a reportable potential for the K166N polymorphism spreading on the Hemagglutinin of pH1N1. This change may enhance Vaccine Escape from the currently selected vaccine target candidate, CA/07 X181.

    The GeneWurx RnR model approximates that HA 166N may appear on a pH1N1 cross-clade background carrying both 188T and 189T, according to the following probabilities.

    • 28% probability sampled by 2013-04-30.
    • 52% probability sampled by 2013-09-30.

    If the HA 166N does appear on a cross-clade background having both 188T and 189T, hospitalisation of subjects under 12 years of age is a potential scenario.

    These probabilities will be updated as additional data is made public. Transparency at this post-pandemic stage is essential to formulate viable responses for the risk groups. Release of sequences and clinical data of a finer detail and higher quantity will allow information-based decisions.


  • #2
    Re: Analysis - HA 166N Polymorphism Potential on pH1N1 Cross-Clade Background with Both 188T and 189T

    Prediction
    Demonstrated in USA
    Triple Polymorphism pH1N1
    HA 166N, 188T & 189T

    2013-11-28


    The United States CDC published a sequence on 2013-09-09 with Clade Crossing evidence sampled on 2013-08-13 from a 57 year old male in Indiana. This Indiana22_C2_57M_2013_08_13 sequence fulfills the triple polymorphism genetic change and timing of the prediction published on 2013-02-26 titled HA 166N Polymorphism Potential on pH1N1 Cross-Clade Background with Both 188T and 189T.
    • Open-Access, Full-Text Investigational Analytic including Genetic Details

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