Hello to all,
We are in a strange situation where a pandemic is announced by a large part of the scientific community while no substancial large scale efforts are made to produce right away a vaccine for this announced disaster.
Many cause haved been claimed to be the reason for this situation.
- Nobody really are sure of which strain will trigger the pandemic,
- Lack of appropriate industrial infrastructure and poor investment in vaccinal industry.
- Poor immunity driven by the current avian H5 strain vaccine.
- The fear for industrials to loose money if they produce massively a wrong vaccine.
- Stringent regulation coupled with this low profit sector.
- And more again, the debate in scientific community is just still not over.
Despite this, more and more voice start to picture a whole new dominant point of view.
Just one or two year ago, the dominant point of view in the community and for WHO was to wait for the "Reassortment event" and that many other strain such as H7N7, H2N2 , or H6 virus could as well sparks the next pandemic.
Slowly but constantly, driven by the constant exchange in the community and also by the different media such as peer reviewd journals, pedagogic journals, main stream media and also by blog and forum like ours, the widespread idea are changing.
The possibility that the H5N1 step directly in our species without any reasortment event like the 1918 virus could have done too is more and more accepted.
The constat that H5N1 is the most advanced virus in the way to a pandemic is also more and more accepted.
The epidemiologic data do not show any sign of reduction in case/mortality rate but the current data is just too much incredible for everyone and every agency or gov or organisation to prep based on this data.
Recently the idea to count on cross-immunity and count on currently availables vaccinal strain haved raised.
Even, Dr.Webster which was from the "we wait for the reassortment" clan has begun to puch this idea for wich I am in agreement.
So...
What do wort the currently availables vaccinals strains against this nasty virus ?
I propose here a little analysis of theses strains based on the most common way to analyse vaccinal strain used in laboratories.
This analysis will be based on the percentage homology between current vaccinal strain and the most recent data for human H5N1 sequences.
We will also try a analysis for the projected antigenic sites based on a previous scientific paper.
This is just the introduction
Please if you want to try the whole process, go in the molecular biology link section in the Mingus's Lab and download the BIOEDIT freeware sequence editor as you can.
As a database containing human H5N1 sequence + vaccinal strain will be kept , every new data could be add and we will asess every new human strain the same way.
I'll try a pedagogic effort to explain all step of my work.
All comments are welcome,
It may be slow... forgive me and be patient... I fight everiday with time
We are in a strange situation where a pandemic is announced by a large part of the scientific community while no substancial large scale efforts are made to produce right away a vaccine for this announced disaster.
Many cause haved been claimed to be the reason for this situation.
- Nobody really are sure of which strain will trigger the pandemic,
- Lack of appropriate industrial infrastructure and poor investment in vaccinal industry.
- Poor immunity driven by the current avian H5 strain vaccine.
- The fear for industrials to loose money if they produce massively a wrong vaccine.
- Stringent regulation coupled with this low profit sector.
- And more again, the debate in scientific community is just still not over.
Despite this, more and more voice start to picture a whole new dominant point of view.
Just one or two year ago, the dominant point of view in the community and for WHO was to wait for the "Reassortment event" and that many other strain such as H7N7, H2N2 , or H6 virus could as well sparks the next pandemic.
Slowly but constantly, driven by the constant exchange in the community and also by the different media such as peer reviewd journals, pedagogic journals, main stream media and also by blog and forum like ours, the widespread idea are changing.
The possibility that the H5N1 step directly in our species without any reasortment event like the 1918 virus could have done too is more and more accepted.
The constat that H5N1 is the most advanced virus in the way to a pandemic is also more and more accepted.
The epidemiologic data do not show any sign of reduction in case/mortality rate but the current data is just too much incredible for everyone and every agency or gov or organisation to prep based on this data.
Recently the idea to count on cross-immunity and count on currently availables vaccinal strain haved raised.
Even, Dr.Webster which was from the "we wait for the reassortment" clan has begun to puch this idea for wich I am in agreement.
So...
What do wort the currently availables vaccinals strains against this nasty virus ?
I propose here a little analysis of theses strains based on the most common way to analyse vaccinal strain used in laboratories.
This analysis will be based on the percentage homology between current vaccinal strain and the most recent data for human H5N1 sequences.
We will also try a analysis for the projected antigenic sites based on a previous scientific paper.
This is just the introduction
Please if you want to try the whole process, go in the molecular biology link section in the Mingus's Lab and download the BIOEDIT freeware sequence editor as you can.
As a database containing human H5N1 sequence + vaccinal strain will be kept , every new data could be add and we will asess every new human strain the same way.
I'll try a pedagogic effort to explain all step of my work.
All comments are welcome,
It may be slow... forgive me and be patient... I fight everiday with time
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