Hello to all science lover,
Many discussion have occured about change that could spark an pandemic with H5N1. Many of them point out the need for H5 to acquire specificity for a2,6 proteoglycan receptor c will give the virus the ability to infect the upper respiratory tract.
http://www.flutrackers.com/forum/sho...=6576#post6576
Some other point toward the the cleavage site an its ability to be fonctionnaly cleaved by exogenous protease in the right kind of cells.
http://www.flutrackers.com/forum/sho...2&postcount=22
http://www.pubmedcentral.gov/article...z&artid=249560
So various discussion there and there have turn around two important features of the protean hemaglutinin which is the major protean determining the influenza's infectivity.
These two feature work together and will determine which kind of cells, which host and witch level of infectivity.
With these two picture already post elsewhere check the shematic drawing I'll post down there.
.
(Mellie edited to fix the broken url only.)
Many discussion have occured about change that could spark an pandemic with H5N1. Many of them point out the need for H5 to acquire specificity for a2,6 proteoglycan receptor c will give the virus the ability to infect the upper respiratory tract.
http://www.flutrackers.com/forum/sho...=6576#post6576
Some other point toward the the cleavage site an its ability to be fonctionnaly cleaved by exogenous protease in the right kind of cells.
http://www.flutrackers.com/forum/sho...2&postcount=22
http://www.pubmedcentral.gov/article...z&artid=249560
So various discussion there and there have turn around two important features of the protean hemaglutinin which is the major protean determining the influenza's infectivity.
These two feature work together and will determine which kind of cells, which host and witch level of infectivity.
With these two picture already post elsewhere check the shematic drawing I'll post down there.
.
(Mellie edited to fix the broken url only.)
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