previous thread abouts Guatemala bat-flu here:
--------------------------------------------------------------------------
we identified a novel influenza A virus, designated as H18N11,
in a flat-faced fruit bat (Artibeus planirostris) from Peru
GenBank accession
numbers CY125942-CY125949), and this virus was designated A/
flat-faced bat/Peru/033/2010 (A/bat/Peru/10) (Table S1).
We sampled 114 Peruvian bats captured during 2010 in
Truenococha and Santa Marta
#
not yet at genbank: http://www.ncbi.nlm.nih.gov/nuccore/CY125942
they knew it since 2010, but didn't talk about it. I guess, it's because if the
current system of funding,grants,journals
they want to have it exclusively and they don't want others working
on it, or talking/speculating about it, before they publish their paper (?)
The Guatemala paper was published in Feb.2012
[ it might take 3 years before they tell us, when there was a (failed) bioterrorist
attack or lab accident using a new manmade virus ?!?
or just when someone succeeded to make/reassort a new flu-virus of real pandemic potential ]
----------------------------
googling for A/flat-faced bat/Peru/033/2010 :
#
PLOS Pathogens: New World Bats Harbor Diverse Influenza A Viruses
Table S1. - PLOS Pathogens
https://www.readcube.com/articles/.....l.ppat.1003657... - Diese Seite übersetzen
ftp.cbi.pku.edu.cn/pub/database/PDB/derived_data/.../pending_waiting.list
Warum sehe ich diese Anzeige?
terrestrial.animalhealth.org/.../new-world-bats-harbo...
biointel.org/
zero hits for http://www.ncbi.nlm.nih.gov/nuccore/CY125942
-----------------------------------
---------edit---------------
now available at genbank ! Oct.20.18:00 MET
differences in promille in the 8 segments:
this is likely all random and doesn't show a more recent common ancester with one of the known
virus-segments than with another one
except maybe the 17g in segment 2 (and H9N2 in segment 5 ?)
comparing the 2 bats with my index-file k4k4s:
252,147,200,---,128,---,109,185 amino differences from the bird index
234,155,204,---,135,---,097,178 for the Guatemala bat
the Peru bat-virus has much higer AT-scores in all segments than the Guatemala bat
--> more mammalean-like, less avian:
this is even higher than the equine H7N7 and influenza B !!
Only flu-C has higher AT-score
so there is maybe either a big difference in the methylation
capabilities of these 2 bat-species, or there is a mammalean reservoir
in Peru that feeds the bats with flu
someone please test the alpacas and llamas
----------edit--------------- better piccaries and tapirs
the common ancester of the Peru and Guatemala bat viruses could have "lived" ~150-200 years ago,
except segments 4,6 , assuming the same mutation rate as in humans,swine,horses
.........................................
since the date of the most recent common ancester of the bat and any other known flu-A segment
is before the date of the most recent common ancester of any two other flu-As (same segment),
the phylo-distance to all known contemporary flu-A segments must be the same.
Any differences can be due to periods of slow evolution or lack of amino-acid mutations
in inner segments of mallard-flu or other such constraints or are just random.
--------------------------------------------------------------------------
we identified a novel influenza A virus, designated as H18N11,
in a flat-faced fruit bat (Artibeus planirostris) from Peru
GenBank accession
numbers CY125942-CY125949), and this virus was designated A/
flat-faced bat/Peru/033/2010 (A/bat/Peru/10) (Table S1).
We sampled 114 Peruvian bats captured during 2010 in
Truenococha and Santa Marta
#
not yet at genbank: http://www.ncbi.nlm.nih.gov/nuccore/CY125942
they knew it since 2010, but didn't talk about it. I guess, it's because if the
current system of funding,grants,journals
they want to have it exclusively and they don't want others working
on it, or talking/speculating about it, before they publish their paper (?)
The Guatemala paper was published in Feb.2012
[ it might take 3 years before they tell us, when there was a (failed) bioterrorist
attack or lab accident using a new manmade virus ?!?
or just when someone succeeded to make/reassort a new flu-virus of real pandemic potential ]
----------------------------
googling for A/flat-faced bat/Peru/033/2010 :
#
PLOS Pathogens: New World Bats Harbor Diverse Influenza A Viruses
Table S1. - PLOS Pathogens
https://www.readcube.com/articles/.....l.ppat.1003657... - Diese Seite übersetzen
ftp.cbi.pku.edu.cn/pub/database/PDB/derived_data/.../pending_waiting.list
Warum sehe ich diese Anzeige?
terrestrial.animalhealth.org/.../new-world-bats-harbo...
biointel.org/
zero hits for http://www.ncbi.nlm.nih.gov/nuccore/CY125942
-----------------------------------
---------edit---------------
now available at genbank ! Oct.20.18:00 MET
differences in promille in the 8 segments:
Code:
0 0 2280 1 >A/flat-faced bat/Peru/033/2010(H18N11) ----------segment 1------------- 2350 536 2280 2 >A/little yellow-shouldered bat/Guatemala/153/2009/05/(H17N10) 3364 767 2280 5954 >DQ064564,A/chicken/Ningxia/4/99,1999//,China,H9N2,1 3364 767 2280 7909 >HM145701,A/duck/Fujian/420/2005,2005//,China,H6N2,1 3368 768 2280 18 >AB256703,A/chicken/Yokohama/aq45/2002,2002//,Japan,H9N2,1 ----------segment 2------------- 2302 523 2271 2 >A/little yellow-shouldered bat/Guatemala/153/2009/05/(H17N10) 2800 636 2271 6797 >EU871834,A/duck/LA/17G/1987,1987//,USA,H3N8 2818 640 2271 2259 >CY053827,A/pekin duck/California/P30/2006,2006/03/06,USA,H4N2 2822 641 2271 8245 >HQ825164,A/turkey/BC/1529-3/2005,2005/05/26,Canada,H3N2 2826 642 2271 5188 >CY139967,A/mallard/Minnesota/AI06-1135/2006,2006//,USA,H4N6 2835 644 2271 4 >A/Brevig Mission/1/1918(H1N1) ----------segment 3------------- 2174 465 2138 3 >A/little yellow-shouldered bat/Guatemala/164/2009/05/ 3199 646 2019 5539 >A/mallard/Interior Alaska/10BM12362R0/2010,2010/08/14,USA,H3N8,3 3208 684 2132 6989 >A/pheasant/MD/4457/1993,1993//,USA,H5N2,3 3216 650 2021 2837 >A/mallard/Interior Alaska/9BM1863/2009,2009/07/01,USA,N6,3 3217 686 2132 6998 >A/chicken/NY/21665-73/1998,1998//,USA,H1N1,3 3222 687 2132 3365 >A/bufflehead/Alberta/399/2007,2007/08/28,Canada,mixed,3 3227 688 2132 446 >A/mallard duck/ALB/1151/1979,1979/08/22,Canada,H6N9,3 3227 688 2132 2899 >A/turkey/Wisconsin/1/1968,1968/06/11,USA,H5N9,3 ----------segment 4------------- 4478 755 1686 4879 >A/turkey/Minnesota/40550/1987,1987//,H5N2,USA 4567 770 1686 4469 >A/sanderling/New Jersey/766/1986,1986/05/12,H2N7,USA ----------segment 5------------- 2112 315 1491 2 >A/little yellow-shouldered bat/Guatemala/153/2009/05/(H17N10) 2858 427 1494 7472 >A/avian/Saudi Arabia/910134/2006,2006//,Saudi Arabia,H9N2 2877 427 1484 7471 >A/chicken/Dubai/463/2003,2003//,United Arab Emirates,H9N2 2891 432 1494 7464 >A/chicken/Iran/AH-1/2006,2006/10/10,Iran,H9N2 2911 435 1494 7466 >A/chicken/Iran/TH88/2009,2009/05/,Iran,H9N2 2911 435 1494 7850 >A/duck/Victoria/5384/2002,2002//,Australia,H4N8 2915 423 1451 7465 >A/chicken/Iran/Ahwaz-1/2006,2006/10/10,Iran,H9N2 2918 436 1494 4332 >A/white fronted goose/Netherlands/22/1999,1999//,Netherlands,H2N2 2918 436 1494 7112 >A/duck/Altai/1285/1991,1991/08/15,Russia,H5N3 ----------segment 6------------- 5989 796 1329 2 >A/little yellowshouldered bat/Guatemala/153/2009/05/(H17N10) 6364 688 1081 5727 >A/chicken/Pakistan/1/2004,2004//,H7N3 6389 683 1069 5655 >A/mallard/Gurjev/263/1982,1982//,H14N5 ----------segment 7------------- 1885 184 976 2 >A/little yellow-shouldered bat/Guatemala/153/2009/05/(H17N10) 3196 289 904 741 >AY664421,A/shorebird/Delaware/224/1997,1997//,USA,H13N6,7 3226 292 905 249 >AB704722,A/duck/Vietnam/OIE-2562/2011,2011/09/17,Viet Nam,H6N6,7 3247 289 890 7762 >EU599304,A/shoveler/Egypt/909864/2004,2004//,Egypt,H7N7,7 3264 300 919 775 >AY664456,A/shorebird/Delaware/207/98 ,1998//,USA,H5N8,7 3278 321 979 4428 >CY125326,A/hooded merganser/New Brunswick/03749/2009,2009/09/14,Canada,H3N8,7 ----------segment 8------------- 0 0 844 1 >A/flat-faced bat/Peru/033/2010(H18N11) 2109 178 844 2 >A/little yellow-shouldered bat/Guatemala/153/2009/05/(H17N10) 3871 314 811 7614 >A/chicken/PA/19241/1997,1997//,USA,H7N2,8 3894 317 814 262 >A/duck/Vietnam/G18-1/2011,2011//,Viet Nam,H3N8,8 3894 317 814 9218 >A/Steller's eider/Alaska/44222-192/2006,2006/09/06,USA,H3N3,8 3901 316 810 1958 >A/chicken/New York/88291-6/2005,2005/07/20,USA,H7N2,8
virus-segments than with another one
except maybe the 17g in segment 2 (and H9N2 in segment 5 ?)
comparing the 2 bats with my index-file k4k4s:
Code:
27 >A/little yellow-shouldered bat/Guatemala/153/2009/05/(H17N10) 1:343,307,339,---,313,---,336,--- 1980//,A/Avian/Index/Africa,HxNx,South Africa,Avian 9:337,297,335,---,309,---,332,--- 1980//,A/Avian/Index/Oceania/,HxNx,Australia 28: 46, 44, 29, 26, 46, 68, 20, 40 A/LYS bat/Guatemala/060/2010,2010/09/(H17N10) 34:338,288,335,519,308,597,348,380 A/equine/Lexington/1/1966(H7N7) 42:340,301,330,428,305,575,331,405 A/Brisbane/59/2007/07/01(H1N1) 54:234,230,217,359,210,449,188,210 A/flat-faced bat/Peru/033/2010(H18N11) 29:345,285,338,528,317,595,328,399 A/duck/LA/17G/1987,1987//,H3N8 30:341,285,332,506,317,604,328,404 A/pekin duck/CA/P30/2006,2006/03/06,H4N2 31:347,280,332,529,314,600,329,401 A/cinnamon teal/CA/44287-325/2007,2007/01/27,H3N8 12:347,293,329,436,315,562,330,388 Index 7 birds similar to BM18 plus BM18 40:344,297,330,436,305,567,340,389 A/Index/early human 41:345,298,328,429,310,563,338,391 A/Puerto Rico/8-1/1934(H1N1) 51:344,294,328,448,322,567,336,388 A/Sw/Jiangsu/s15/2011,2011/02/05 25:348,302,338,427,321,598,334,389 A/mallard/WI/42/1975,1975// 10:344,298,335,---,303,---,332,--- A/Avian/Index/Ozeania 11:345,305,338,---,298,---,333,--- A/Avian/Index/South America 49:359,295,340,438,315,553,335,409 A/Sw/Guangdong/34/2006(H1N1) 5:346,301,334,---,312,---,328,--- 1980//,A/Avian/Index/Europe,HxNx,Germany,Avian 45:350,296,342,436,313,566,328,413 A/******/index/2009/02/01 50:347,305,332,445,311,567,333,373 A/Sw/Germany/2/1981(H1N1)=1578 54 >A/flat-faced bat/Peru/033/2010(H18N11) 2:344,291,334,---,306,---,342,--- 2000,A/Avian/Index/Africa,HxNx,Egypt,Avian 3:343,291,340,---,295,---,331,--- 1980//,A/Avian/Index/Asia,HxNx,China,Avian 10:336,285,333,---,287,---,334,--- A/Avian/Index/Ozeania 11:347,289,330,---,298,---,323,--- A/Avian/Index/South America 27:234,230,217,359,210,449,188,210 A/LYS bat/Guatemala/153/2009/05/(H17N10) 28:232,237,216,355,216,442,189,209 A/LYS bat/Guatemala/060/2010,2010/09/(H17N10) 2283 2271 2142 1695 1494 1329 979 844 33:336,284,337,531,298,576,324,415 A/equine/Gansu/7/2008,2008//,H3N8 34:329,287,309,503,295,615,338,415 A/equine/Lexington/1/1966(H7N7) 9:338,289,341,---,292,---,331,--- 1980//,A/Avian/Index/Oceania/,HxNx,Australia 29:342,279,332,526,305,573,345,410 A/duck/LA/17G/1987,1987//,H3N8 30:345,281,328,516,307,592,331,411 A/pekin duck/CA/P30/2006,2006/03/06,H4N2 31:347,281,328,521,300,568,330,416 A/cinnamon teal/CA/44287-325/2007,2007/01/27,H3N8 40:347,280,337,423,308,573,332,425 A/Index/early human 39:352,283,331,421,308,573,334,424 A/Brevig Mission/1/1918(H1N1) 44:354,283,338,527,303,590,330,440 A/Sw/Ontario/33853/2005(H3N2) 48:354,293,328,423,304,567,334,433 A/Sw/Iowa/24297/1991(H1N1) 12:351,289,335,421,305,573,325,427 Index 7 birds similar to BM18 plus BM18 17:348,295,338,409,307,580,324,413 A/Ck/Mexico/31381-7/1994,1994//(H5N2) 32:346,295,331,532,297,575,326,415 A/equine/Miami/1/1963,1963//,H3N8 50:351,287,340,428,293,574,328,400 A/Sw/Germany/2/1981(H1N1)=1578
234,155,204,---,135,---,097,178 for the Guatemala bat
the Peru bat-virus has much higer AT-scores in all segments than the Guatemala bat
--> more mammalean-like, less avian:
Code:
6316,6393,6479,6208,5702,5814,5740,5936, = 6152(13098) >A/flat-faced bat/Peru/033/2010(H18N11) 5711,5719,5873,5802,5361,5613,5419,5734, = 5680(13035) >A/LYS bat/Guatemala/153/2009/05/(H17N10) 5716,5719,5873,5808,5361,5613,5419,5734, = 5682(13035) >A/LYS bat/Guatemala/164/2009/05/ 5561,5659,5620,5802,5310,5751,5152,5465, = 5574(13133) >A/Brevig Mission/1/1918(H1N1)
Only flu-C has higher AT-score
so there is maybe either a big difference in the methylation
capabilities of these 2 bat-species, or there is a mammalean reservoir
in Peru that feeds the bats with flu
someone please test the alpacas and llamas
----------edit--------------- better piccaries and tapirs
the common ancester of the Peru and Guatemala bat viruses could have "lived" ~150-200 years ago,
except segments 4,6 , assuming the same mutation rate as in humans,swine,horses
.........................................
since the date of the most recent common ancester of the bat and any other known flu-A segment
is before the date of the most recent common ancester of any two other flu-As (same segment),
the phylo-distance to all known contemporary flu-A segments must be the same.
Any differences can be due to periods of slow evolution or lack of amino-acid mutations
in inner segments of mallard-flu or other such constraints or are just random.
Comment