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Contagion: Controversy Erupts over Man-Made Pandemic Avian Flu Virus

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  • Contagion: Controversy Erupts over Man-Made Pandemic Avian Flu Virus

    Contagion: Controversy Erupts over Man-Made Pandemic Avian Flu Virus

    Two teams of scientists have independently constructed a deadly strain of flu. Some say the results should never be published
    By Jeneen Interlandi December 9, 2011
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    For years now, the research has suggested that any mutations that enhanced the virusís ability to spread among humans, would simultaneously make it less deadly. But in a recent batch of as-yet-unpublished studies, two scientists - Yoshihiro Kawaoka from the University of Wisconsin, Madison and Ron Fouchier of Erasmus Medical Center, in the Netherlands Ė have shown otherwise. Working separately, they each hit on a combination of mutations (five, in Dr. Fouchierís case) that makes H5N1 airborne (enabling it to spread readily between humans), without making it less deadly. In laboratory experiments, ferrets infected with this mutant strain passed it to other ferrets in nearby cages (ferrets are a common subject of flu studies because they react to flu viruses in a similar way to humans). A significant proportion of infected subjects died.

    Efforts to publish those findings have been fraught. Critics say that making the methodology or gene sequences widely available, amounts to giving would-be bioterrorists an easy recipe. They also worry that these manmade strains might escape from the lab.

    Proponents counter that the threat of a global pandemic, were this mutated strain to arise in nature, is far greater than the threat of bioterrorism. Understanding what combination of mutations could transform H5N1 into a human pandemic virus, helps epidemiologists know what to watch out for in the wild, and gives them a leg up on preparing countermeasures; they can, for example, test existing H5N1 vaccines and antiviral drugs against the new strain in the lab, before it actually emerges in the natural world.

    Both papers are being reviewed by the National Science Advisory Board for Biosecurity (NSABB),...

    More: http://www.scientificamerican.com/ar...T_EVO_20111213
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