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Researchers believe they have solved vaccine blood-clot puzzle ‘All mRNA-based vaccines should represent safe products,’ paper says

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  • Researchers believe they have solved vaccine blood-clot puzzle ‘All mRNA-based vaccines should represent safe products,’ paper says

    Researchers at the Goethe-University of Frankfurt and other sites explained that vaccines using a different technology known as messenger RNA (mRNA), such as those developed by BioNTech with Pfizer and Moderna, deliver the genetic material of the coronavirus spike protein only to fluid found inside cells, not to the nucleus of the cells.

    “All mRNA-based vaccines should represent safe products,” the paper said.

    It suggests vaccine makers using adenovirus vectors could modify the sequence of the spike protein “to avoid unintended splice reactions and to increase the safety of these pharmaceutical products.”

    It comes as doctors in the UK have been urged to look for signs of stroke in people receiving the Oxford/AstraZeneca vaccine after three young patients were admitted to hospital and one died.



    Researchers believe they have solved vaccine blood-clot puzzle


    ‘All mRNA-based vaccines should represent safe products,’ paper says

    Samuel Osborne@SamuelOsborne93 2 days ago

    60 comments

    ...
    Researchers at the Goethe-University of Frankfurt and other sites explained that vaccines using a different technology known as messenger RNA (mRNA), such as those developed by BioNTech with Pfizer and Moderna, deliver the genetic material of the coronavirus spike protein only to fluid found inside cells, not to the nucleus of the cells.

    “All mRNA-based vaccines should represent safe products,” the paper said.

    It suggests vaccine makers using adenovirus vectors could modify the sequence of the spike protein “to avoid unintended splice reactions and to increase the safety of these pharmaceutical products.”

    It comes as doctors in the UK have been urged to look for signs of stroke in people receiving the Oxford/AstraZeneca vaccine after three young patients were admitted to hospital and one died....
    _____________________________________________

    Ask Congress to Investigate COVID Origins and Government Response to Pandemic.

    i love myself. the quietest. simplest. most powerful. revolution ever. ---- nayyirah waheed

    "...there’s an obvious contest that’s happening between different sectors of the colonial ruling class in this country. And they would, if they could, lump us into their beef, their struggle." ---- Omali Yeshitela, African People’s Socialist Party

    (My posts are not intended as advice or professional assessments of any kind.)
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  • #2
    During the last months many countries have started the immunization of millions of people by using vector-based vaccines. Unfortunately, severe side effects became overt during these vaccination campaigns: cerebral venous sinus thromboses (CVST), absolutely rare under norma...

    This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.

    Research Article

    “Vaccine-Induced Covid-19 Mimicry” Syndrome:
    Splice reactions within the SARS-CoV-2 Spike open reading frame result in Spike protein variants that may cause thromboembolic events in patients immunized with vector-based vaccines

    Eric Kowarz, Lea Krutzke, Jenny Reis, Silvia Bracharz, Stefan Kochanek, Rolf Marschalek

    DOI: 10.21203/rs.3.rs-558954/v1

    Download PDF

    License:

    This work is licensed under a CC BY 4.0 License. Read Full License

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    View author declarations.

    During the last months many countries have started the immunization of millions of people by using vector-based vaccines. Unfortunately, severe side effects became overt during these vaccination campaigns: cerebral venous sinus thromboses (CVST), absolutely rare under normal life conditions, were found as a severe side effect that occured 4-14 days after first vaccinations. Besides CVST, Splanchnic Vein Thrombosis (SVT) was also observed. This type of adverse event has not been observed in the clinical studies of AstraZeneca, and therefore led immediately to a halt in vaccinations in several european countries. These events were mostly associated with thrombocytopenia, and thus, similar to the well-known Heparin-induced thrombo­cytopenia (HIT). Meanwhile, scientists have proposed a mechanism to explain this vaccine-induced thrombocytopenia. However, they do not provide a satisfactory explanation for the late thromboembolic events. Here, we present data that may explain these severe side effects which have been attributed to adenoviral vaccines. According to our results, transcription of wildtype and codon-optimized Spike open reading frames enables alternative splice events that lead to C-terminal truncated, soluble Spike protein variants. These soluble Spike variants may initiate severe side effects when binding to ACE2-expressing endothelial cells in blood vessels. In analogy to the thromboembolic events caused by Spike protein encoded by the SARS-CoV-2 virus, we termed the underlying disease mechanism the “Vaccine-Induced Covid-19 Mimicry” syndrome (VIC19M syndrome).
    Keywords

    Vector-based vaccines, CVST, SVT, thrombosis, splicing, Spike protein




    _____________________________________________

    Ask Congress to Investigate COVID Origins and Government Response to Pandemic.

    i love myself. the quietest. simplest. most powerful. revolution ever. ---- nayyirah waheed

    "...there’s an obvious contest that’s happening between different sectors of the colonial ruling class in this country. And they would, if they could, lump us into their beef, their struggle." ---- Omali Yeshitela, African People’s Socialist Party

    (My posts are not intended as advice or professional assessments of any kind.)
    Never forget Excalibur.

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