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In a small study, researchers did not see a strong imprinting effect on influenza vaccination based on when participants were born, according to data presented at the National Foundation for Infectious Diseases? Annual Conference on Vaccinology Research.
Amy Sherman, MD, an infectious disease fellow at Emory University, and colleagues studied 20 total participants in two cohorts: those born between 1948 and 1957, and those born between 1968 and 1977.
?Based on epidemiological data, H1N1 was the primary strain circulating before 1957, and H3N2 was the primary strain circulating between 1968 and 1977,? Sherman explained to Infectious Disease News. ?[According to] the theory of imprinting and the doctrine of original antigenic sin, individuals produce the most robust immune response to the first influenza A virus they encountered as a child, even when they encounter novel influenza viruses later in life. Based on this theory, the birth cohorts were defined to select for individuals who were born in these specific years, to see if there was an imprinting effect based on the ?first flu? that they encountered as a child.?
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Amy Sherman, MD, an infectious disease fellow at Emory University, and colleagues studied 20 total participants in two cohorts: those born between 1948 and 1957, and those born between 1968 and 1977.
?Based on epidemiological data, H1N1 was the primary strain circulating before 1957, and H3N2 was the primary strain circulating between 1968 and 1977,? Sherman explained to Infectious Disease News. ?[According to] the theory of imprinting and the doctrine of original antigenic sin, individuals produce the most robust immune response to the first influenza A virus they encountered as a child, even when they encounter novel influenza viruses later in life. Based on this theory, the birth cohorts were defined to select for individuals who were born in these specific years, to see if there was an imprinting effect based on the ?first flu? that they encountered as a child.?
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