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Discovery points to a new path toward a universal flu vaccine

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  • Discovery points to a new path toward a universal flu vaccine

    Flu vaccines can be something of a shot in the dark. Not only must they be given yearly, there's no guarantee the strains against which they protect will be the ones circulating once the season arrives.
    New research by Rockefeller University scientists and their colleagues suggests it may be possible to harness a previously unknown mechanism within the immune system to create more effective and efficient vaccines against this ever-mutating virus.
    "While the conventional flu vaccine protects only against specific strains, usually three of them, our experiments show that by including modified antibodies within the vaccine it may be possible to elicit broad protection against many strains simultaneously," says senior study author Jeffrey Ravetch, Theresa and Eugene M. Lang Professor and head of the Leonard Wagner Laboratory of Molecular Genetics and Immunology. "We believe these results may represent a preliminary step toward a universal flu vaccine, one that is effective against a broad range of the flu viruses."

    The conventional flu vaccine requires annual shots to protect against only a few specific strains. However, researchers at Rockefeller University and their colleagues have shown that by including modified antibodies within the vaccine it may be possible to elicit broad protection against many strains simultaneously.


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