Currently approved flu vaccines are less effective in the elderly, yet an estimated 90% of influenza-related deaths occur in people over 65. A paper published in PLOS Pathogens reports on the challenges scientists encountered when they were trying to develop a better flu vaccine.
Because immune systems in older people are generally less responsive to vaccination, Jay Evans and colleagues from GlaxoSmithKline Vaccines in Hamilton, USA, were testing so-called adjuvants - vaccine components that provoke a stronger immune reaction - that could be added to the regular flu vaccine cocktail to prompt even weaker immune systems to develop protective immunity against subsequent encounters with the flu virus.
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Because immune systems in older people are generally less responsive to vaccination, Jay Evans and colleagues from GlaxoSmithKline Vaccines in Hamilton, USA, were testing so-called adjuvants - vaccine components that provoke a stronger immune reaction - that could be added to the regular flu vaccine cocktail to prompt even weaker immune systems to develop protective immunity against subsequent encounters with the flu virus.
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