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Decreasing potential iatrogenic risks associated with influenza vaccines

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  • Decreasing potential iatrogenic risks associated with influenza vaccines

    https://patents.google.com/patent/US20190078060A1/en
    Decreasing potential iatrogenic risks associated with influenza vaccines

    Inventor Jens-Peter Gregersen Current Assignee Novartis AG Abstract

    Influenza viruses for use in preparing human vaccines have traditionally been grown on embryonated hen eggs, although more modern techniques grow the virus in mammalian cell culture e.g. on Vero, MDCK or PER.C6 cell lines. The inventor has realised that the conditions used for influenza virus culture can increase the risk that pathogens other than influenza virus may grow in the cell lines and have identified specific contamination risks. Suitable tests can thus be performed during manufacture in order to ensure safety and avoid iatrogenic infections.


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