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WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

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  • WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

    WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

    [Original Protected PDF Document at: LINK. EDITED.]
    [These images are from the above document and are somewhat modified in order to magnify or reduce size and improve readability. IOH.]


    <table style="width: auto;"><tbody><tr><td></td></tr><tr><td style="font-family: arial,sans-serif; font-size: 11px; text-align: right;">From TABLES</td></tr></tbody></table>

    <table style="width: auto;"><tbody><tr><td></td></tr><tr><td style="font-family: arial,sans-serif; font-size: 11px; text-align: right;">From TABLES</td></tr></tbody></table>

    <table style="width: auto;"><tbody><tr><td></td></tr><tr><td style="font-family: arial,sans-serif; font-size: 11px; text-align: right;">From TABLES</td></tr></tbody></table>

    <table style="width: auto;"><tbody><tr><td></td></tr><tr><td style="font-family: arial,sans-serif; font-size: 11px; text-align: right;">From TABLES</td></tr></tbody></table>

    <table style="width: auto;"><tbody><tr><td></td></tr><tr><td style="font-family: arial,sans-serif; font-size: 11px; text-align: right;">From TABLES</td></tr></tbody></table>

    <table style="width: auto;"><tbody><tr><td></td></tr><tr><td style="font-family: arial,sans-serif; font-size: 11px; text-align: right;">From TABLES</td></tr></tbody></table>

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  • #2
    Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

    So this document specifically says Clade 7 has been found in birds in Asia.
    [it's in the previous post]

    I think it is in Vietnam.

    "It says "Antigenic diversity is also present within clade 7 and viruses such as A/chicken/Vietnam/NCDV-03/2008 show reduced reactivity with antisera to the clade 7 reference strain A/chicken/Vietnam/NCDV-016/2008."

    And the vaccine isn't working.

    Comment


    • #3
      Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

      protected non-text format ?
      why ?
      is it public or not ? copyrighted by WHO-->UNO ?
      I'm interested in expert panflu damage estimates
      my current links: http://bit.ly/hFI7H ILI-charts: http://bit.ly/CcRgT

      Comment


      • #4
        Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

        Originally posted by gsgs View Post
        protected non-text format ?
        why ?
        is it public or not ? copyrighted by WHO-->UNO ?
        PDF file is public

        Comment


        • #5
          Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

          Originally posted by Commonground View Post
          So this document specifically says Clade 7 has been found in birds in Asia.
          [it's in the previous post]

          I think it is in Vietnam.

          "It says "Antigenic diversity is also present within clade 7 and viruses such as A/chicken/Vietnam/NCDV-03/2008 show reduced reactivity with antisera to the clade 7 reference strain A/chicken/Vietnam/NCDV-016/2008."

          And the vaccine isn't working.
          Noticably absent is any discussion of A/Beijing/1/2009, which was the first of the recent series.
          The witholding of that data (and the other 5 human isolates) once again points toward clade 7.

          Comment


          • #6
            Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

            Originally posted by niman View Post
            It's password protected. It appears no part of it can be cut and pasted or copied. It may be printed.

            What exactly does "permissions password" mean?
            The salvage of human life ought to be placed above barter and exchange ~ Louis Harris, 1918

            Comment


            • #7
              Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

              The China story is pretty obvious to those paying attention. The first case was in Beijing. She (19F) developed symptoms on Dec 24 and died Jan 5. Thus, A/Beijing/1/2009 was isolated in early January and was widely reported. It did not have reassortment with human genes, indicdating ALL EIGHT gene segements had been sequenced. Only HA would be required for the phylogenetic tree WHO just published, and the sequence or placement on the tree would CLEARLY show it was clade 7.

              However, only two of the eight isolates are on the tree. These are the more common clade 2.3.4, which accounted for almost all prior human cases in China, and clade 2.3.2 which was said to be the "first" human case, but anyone paying attention knew that the culler in South Korea who was H5 PCR confirmed was infected with clade 2.3.2, which is what caused the outbreaks in South Korea, Japan, and Russia (and is carried by wild birds between Hong Kong (where it appeared in early 2008 and early 2009 as well as whooper swans in Japan in the spring of 2008).

              The clade 2.3.2 was from a case who developed symptoms on Jan 19 and died Jan 26, so China had no problem getting this sequence into the WHO tree, but the only other isolate was clade 2.3.4.

              Thus, it is likely that 6 of the 8 human cases in China were clade 7, but only data on clade 2.3.2 and 2.3.4 were released.

              Comment


              • #8
                Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

                Originally posted by mixin View Post
                It's password protected. It appears no part of it can be cut and pasted or copied. It may be printed.

                What exactly does "permissions password" mean?
                It is on this thread and is not password protected. Anyone can download and save the file.
                Last edited by sharon sanders; February 14, 2009, 12:40 PM. Reason: typo edit

                Comment


                • #9
                  Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

                  Thank you Dr. Niman to take time to explain what you observe. I cannot read an order. I appreciate when those which are specialized take time to popularize information for a broader audience.

                  Comment


                  • #10
                    Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

                    Originally posted by niman View Post
                    It is on this thread and is not password protected. Anyone can download and save the file.
                    Have you looked at your link? I'd cut and paste the password protection info for you, except it won't let me.
                    The salvage of human life ought to be placed above barter and exchange ~ Louis Harris, 1918

                    Comment


                    • #11
                      Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

                      Originally posted by mixin View Post
                      Have you looked at your link? I'd cut and paste the password protection info for you, except it won't let me.
                      I've downloaded and saved the document. No password required.

                      Comment


                      • #12
                        Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

                        Originally posted by Muscade View Post
                        Thank you Dr. Niman to take time to explain what you observe. I cannot read an order. I appreciate when those which are specialized take time to popularize information for a broader audience.
                        The trees really are not that hard. Each node or branch represents a new clade or sub-clade as indicated on the right of the figure.

                        The individual isolates are named with species (if no species is listed it is human), followed by the location, sample number, and year listed.

                        Sample numbers are usually assigned sequentially (sometimes for each location) and start over for the season or year.

                        A/Hunan/1/2009 was the first isolate in 2009 in Hunan and would have been from the 16M who died January 20. A/Hunan/2/2009 was the 2 year who recovered. A/Hunan/3/2009 would be the 21F who also recovered, but developed symptoms Jan23 (and is the only isolate that might not have been characterized in time for the WHO publication). AGuangxi/1/2009 was the first isoalte from Guangxi, which was a case that died Jan26 (most isolates are from samples collected near the time of death when viral load is highest).

                        A/Beijing/1/2009 was from the 19F who developed stmptoms on Dec 24, 2008 and died January 5, 2009. All of these dates are from WHO situation updates for China.

                        However, A/Beijing/1/2009 was also widely discussed in media reports based on MOH press conferences, which indicated there was no reassortment and differences with other isolates in China represented small variations.

                        However, China, like WHO, would not give the clade number and the six omitted cases in the WHO discussion are GLARING.

                        Clade 7 is a concern because there is no pandemic vaccine, and it is resistant to most poultry vaccines. The released sequneces from poultry in Shanxi and Hunan also have MANY receptor binding domain changes, which is why it is a cause for concern and why WHO and China won't talk about the clade in multiple human cases, and why no sequences are being released.

                        Panasonic knows what it is doing. Reading between the lines is VERY easy (especially for those who can read a sequence, even when it is withheld).

                        Comment


                        • #13
                          Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

                          Has Clade 7 been in Vietnam since 2008? And if so, why aren't you just as concerned about Vietnam, as you are about China?

                          Why haven't we had more infected people in Vietnam?

                          Comment


                          • #14
                            Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

                            Originally posted by niman View Post
                            I've downloaded and saved the document. No password required.
                            Yes, you can save it for viewing and you can print it; but nothing else.

                            I have not found any way to copy and paste any part of a locked .pdf doc.

                            Here, I typed the info from their locked security icon.

                            Security settings: this document has an open password or a modify password
                            You cannot edit or copy this document

                            All contents of this document are encrypted and search engines cannot access this document's metadata.

                            Permission Details: Password Security:

                            Document Open Password: No
                            Permissions Password: Yes
                            Printing: High Resolution
                            Changing the Document: Not Allowed
                            Commenting: Not Allowed
                            Form Field Fill-in or Signing: Not Allowed
                            Document Assembly: Not Allowed
                            Content Copying: Not Allowed
                            Content Accessibility Enabled: Not Allowed
                            Page Extraction: Not Allowed
                            Encryption Level: 128-bit RC4

                            Printing: Allowed
                            Content Copying for Accessibility: Allowed
                            The salvage of human life ought to be placed above barter and exchange ~ Louis Harris, 1918

                            Comment


                            • #15
                              Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

                              Originally posted by Commonground View Post
                              Has Clade 7 been in Vietnam since 2008? And if so, why aren't you just as concerned about Vietnam, as you are about China?

                              Why haven't we had more infected people in Vietnam?
                              The cluster in Vietnam was probably clade 7. China has a lot more people and poultry and, as is obvious in the WHO report, they are withholding the clade 7 info, so the sudden halt in reported cases (and failure to report H5N1 infected poultry) send strong signals.

                              Comment

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