average number of differences in a pair of
H5N1-PB2
the recent decline is because H5N1 concentrates to 2 or 3 strains
recently and because Indonesian sequences from 2007,2008
are missing. However the diversity inside the same strain is
usually increasing
H5N1-PB2
Code:
year,differences,pairs considered --------------------------------- 1997: 107.8 961 1998: 00.00 1 1999: 15.84 25 2000: 81.96 100 2001: 73.89 1849 2002: 82.86 2401 2003: 63.47 3969 2004: 73.85 20736 2005: 97.28 58081 2006: 78.19 71289 2007: 76.42 6561 2008: 68.73 49
recently and because Indonesian sequences from 2007,2008
are missing. However the diversity inside the same strain is
usually increasing
Code:
differences in PB2 between pairs of some proposed vaccine strains: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 --------------------------------------------------------------------------------------------------------- 1 >A/HK/156/97(H5N1) 0 318 312 312 323 296 321 319 321 308 318 294 301 302 321 303 2 >A/VNM/1194/04(H5N1) 318 0 23 60 63 170 62 55 62 22 56 162 163 36 58 27 3 >A/VNM/1203/04(H5N1) 312 23 0 61 62 176 63 56 63 25 57 169 172 35 59 30 4 >A/IDN/5/05(H5N1) 312 60 61 0 72 203 81 74 81 61 76 186 186 35 87 45 5 >A/human/Zhejiang/16/06(H5N1) 323 63 62 72 0 195 77 67 77 51 71 187 192 50 72 44 6 >A/China/GD01/06(H5N1) 296 170 176 203 195 0 194 186 194 167 189 16 64 172 192 161 7 >A/Shenzhen/406H/06(H5N1) 321 62 63 81 77 194 0 48 0 58 49 188 191 56 50 51 8 >A/Turkey/15/06(H5N1) 319 55 56 74 67 186 48 0 48 51 12 181 182 52 19 46 9 >A/human/China/GD02/06(H5N1) 321 62 63 81 77 194 0 48 0 58 49 188 191 56 50 51 10 >A/HK/213/03(H5N1) 308 22 25 61 51 167 58 51 58 0 52 159 164 26 54 17 11 >A/turkey/Turkey/1/05(H5N1) 318 56 57 76 71 189 49 12 49 52 0 183 183 51 17 45 12 >A/Jap.white-eye/HK/1038/06(H5N1) 294 162 169 186 187 16 188 181 188 159 183 0 60 164 186 153 13 >A/Gs/Guiyang/337/06(H5N1) 301 163 172 186 192 64 191 182 191 164 183 60 0 165 188 158 14 >A/Dk/Hunan/795/02(H5N1) 302 36 35 35 50 172 56 52 56 26 51 164 165 0 52 20 15 >A/Ck/India/NIV33487/06(H5N1) 321 58 59 87 72 192 50 19 50 54 17 186 188 52 0 47 16 >A/Dk/Guangxi/50/2001(H5N1) 303 27 30 45 44 161 51 46 51 17 45 153 158 20 47 0 --------------------------------------------------------------------------------------------------------- 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 Glaxo's Prepandrix: 23(VNM),60(IDN),56(TRK),63(ZHE),58(IND) Gx50: 30(VNM),45(IDN),45(TRK),45(ZHE),47(IND)
Code:
for HA: 1 2 3 4 5 6 7 8 9 10 ----------------------------------------------------------------------- 1 A/Dk/Guangxi/50/01 0 32 32 43 52 44 59 43 61 47 2 A/VNM/1194/04 32 0 14 59 66 60 79 59 73 65 3 A/VNM/1203/04 32 14 0 57 68 58 76 57 75 63 4 A/Anhui/1/05 43 59 57 0 62 6 91 16 73 61 5 A/turkey/Turkey/1/05 52 66 68 62 0 63 96 62 26 66 6 A/Dk/Laos/3295/06 44 60 58 6 63 0 92 17 74 62 7 A/Gs/Guiyang/337/06 59 79 76 91 96 92 0 89 104 93 8 A/Jap.white-eye/HK/1038/06 43 59 57 16 62 17 89 0 75 59 9 A/Egypt/2321-NAMRU3/2007 61 73 75 73 26 74 104 75 0 74 10 A/IDN/5/05 47 65 63 61 66 62 93 59 74 0 Glaxo's Prepandrix: 14(VNM),65(IDN),66(TRK),59(ANH) Gx50: 32(VNM),47(IDN),52(TRK),43(ANH) I ask WHO to test antigenicity of A/Dk/Guangxi/50/2001(H5N1) as a vaccine-candidate in ferrets and compare it with the other H5N1-vaccine candidates and to publish the results !
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