Hello,
I said often that it is hard to reduce the mutations necessary to produce a pandemic strain to a simple list of mutation.
Especially when talking about the surface Hemagglutinin gene because there is no example of previous human H5 subtype.
The fact is that 3D shape & positionnal mutation are in inter-relation.
Others early list of relevant mutation where bases on comparison with others subtype like H3, H2, H1.
A recent publication developped a model that seem to be of good predicting value.
Computational studies of H5N1 hemagglutinin binding with SA-α-2, 3-Gal and SA-α-2, 6-
This thread is intended to record them for a quick recall whe it is needed.
Also, If others mutation on others genes are relevant for human adaptation we could list them here.
There is the amino acid code for translation and for the single letter vs tree letter code.
The Amino Acid Code - Reference
I said often that it is hard to reduce the mutations necessary to produce a pandemic strain to a simple list of mutation.
Especially when talking about the surface Hemagglutinin gene because there is no example of previous human H5 subtype.
The fact is that 3D shape & positionnal mutation are in inter-relation.
Others early list of relevant mutation where bases on comparison with others subtype like H3, H2, H1.
A recent publication developped a model that seem to be of good predicting value.
Computational studies of H5N1 hemagglutinin binding with SA-α-2, 3-Gal and SA-α-2, 6-
This thread is intended to record them for a quick recall whe it is needed.
Also, If others mutation on others genes are relevant for human adaptation we could list them here.
There is the amino acid code for translation and for the single letter vs tree letter code.
The Amino Acid Code - Reference
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