Hello all,
Now that we explore how the genetic code is the recipe to build all protein and that this is this major life process that virus target while they try to infect us... Majors constituents of life and the chain of biochemical influence
... now that we see what are the generals mechanism that allow Influenza to enter our cells via the hemmagglutininn... How hemaglutinin work
we could try to understand what exactly is responsible for the ability of the recepror binding receptor (RBS) to infect avian ( mostly a2,3 cells ) or human cells ( mostly a2,6 cells ).
Many individuals "mutation" have been spotted to explain why this change happen...
Genomic Signatures of Human versus Avian Influenza A Viruses - Mutations to check out
Evidence of an absence: the genetic origins of the 1918 pandemic influenza virus.
Early alterations of the receptor-binding properties of H1, H2, and H3 avian influenza virus hemagglutinins after their introduction into mammals.
But this "singles point amino acid mutation" do not explain it all.
Every sub-class of hemaglutinnin seem to have is own way to step species and it is hard to extrapolate what could be the recquired H5 change to allow this to happen.
The reallity is that there is also a strong 3D shape variable that is responsible for that change and "cross-species" capability.
There is also many other change recquire outside of the HA gene but the current H5 do not seen to have problem to replicate in our cells.
The last step seem to be "efficient airborn specificity" and this trait is beleive to be controlled by change in the hemaglutinnin.
So...
In order to understand the importance of the general 3 dimentionnal shape for a protein activity and for the RBS specificity, I will here try to explain some basic protein structural concepts.
After this you will be more "equipped" to fully understand the theoriticals computer models I exposed in that thread...
http://www.flutrackers.com/forum/showthread.php?t=9645
Now that we explore how the genetic code is the recipe to build all protein and that this is this major life process that virus target while they try to infect us... Majors constituents of life and the chain of biochemical influence
... now that we see what are the generals mechanism that allow Influenza to enter our cells via the hemmagglutininn... How hemaglutinin work
we could try to understand what exactly is responsible for the ability of the recepror binding receptor (RBS) to infect avian ( mostly a2,3 cells ) or human cells ( mostly a2,6 cells ).
Many individuals "mutation" have been spotted to explain why this change happen...
Genomic Signatures of Human versus Avian Influenza A Viruses - Mutations to check out
Evidence of an absence: the genetic origins of the 1918 pandemic influenza virus.
Early alterations of the receptor-binding properties of H1, H2, and H3 avian influenza virus hemagglutinins after their introduction into mammals.
But this "singles point amino acid mutation" do not explain it all.
Every sub-class of hemaglutinnin seem to have is own way to step species and it is hard to extrapolate what could be the recquired H5 change to allow this to happen.
The reallity is that there is also a strong 3D shape variable that is responsible for that change and "cross-species" capability.
There is also many other change recquire outside of the HA gene but the current H5 do not seen to have problem to replicate in our cells.
The last step seem to be "efficient airborn specificity" and this trait is beleive to be controlled by change in the hemaglutinnin.
So...
In order to understand the importance of the general 3 dimentionnal shape for a protein activity and for the RBS specificity, I will here try to explain some basic protein structural concepts.
After this you will be more "equipped" to fully understand the theoriticals computer models I exposed in that thread...
http://www.flutrackers.com/forum/showthread.php?t=9645
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