Identification of protective and non-protective T cell epitopes in influenza

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Identification of protective and non-protective T cell epitopes in influenza <?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" /><o:p></o:p>
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Vaccine Volume 24, Issue 4 , 23 January 2006, Pages 452-456 <o:p></o:p>
doi:10.1016/j.vaccine.2005.07.090<o:p></o:p>
Sherry R. Crowe, Shannon C. Miller and David L. Woodland, <o:p></o:p>
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Trudeau Institute, Department of Immunology, 154 Algoquin Ave, Saranac Lake, NY 12983, USA <o:p></o:p>
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Received 14 March 2005; accepted 29 July 2005. Available online 18 August 2005. <o:p></o:p>
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Abstract<o:p></o:p>
Understanding the immune response to different CD8 T cell epitopes is important for the development of vaccines designed to promote protective cellular immunity. Recently, we have shown that vaccination with the PA224?233/Db epitope of influenza virus was poorly protective in terms of viral clearance. To determine if other influenza virus epitopes behave in this manner, we analyzed the ability of three newly identified CD8 T cell epitopes and three previously defined epitopes to provide protection following vaccination and viral challenge. All six of the peptide-based vaccinations resulted in significantly increased numbers of epitope-specific CD8 T cells in the spleen. Interestingly, we found that vaccination with three peptides (HA332?340, M1128?135, or PA224?233) resulted in delayed viral clearance following infection. These findings indicate that some epitopes have a detrimental impact on viral clearance and have important implications for the development of vaccination strategies designed to provide protection against subsequent influenza virus challenge. <o:p></o:p>
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Keywords: CD8 T cells; Vaccination; Influenza; Epitope

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Corresponding author. Tel.: +1 518 891 3080; fax: +1 518 891 5126.<o:p></o:p>

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Re: Identification of protective and non-protective T cell epitopes in influenza

was it in humans ?
some vaccinations can even be detrimental ?
the reason for differences in epitope-vaccination response lies in the 3d-structure ?

[Ganseerpel]

Re: Identification of protective and non-protective T cell epitopes in influenza

was it in humans ?
some vaccinations can even be detrimental ?
the reason for differences in epitope-vaccination response lies in the 3d-structure ?

One of the reasons of a negative effect of vacc. is original sin. I believe we hd a discussion about that.

In humans the principle is the same, the immune response depends on the HLA type, ans there is a hierarchy in the effectiveness of the IResponse. New studies with transgenic mice expressing human HLA show that the mecanism is universal and will permit to accelerate the specific research of vaccines for viral and tumoral antigens. On the other hand the hierarchy can change and even be manipulated.

Differences in the immune response are mainly due to lack of matching in HLA type, perhaps this is one of the reasons for the hitherto unexplained susceptility of some people and clusters to H5N1 infection, whereas the majority seems to be rather resistent to the current H5 strains, at least some studies support this hypothesis.
(Low Frequency of Poultry-to-Human H5N1 Virus Transmission)