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Lessons learned from twins in autoimmune and chronic inflammatory diseases
Journal of Autoimmunity
Available online 18 April 2017
Corresponding author. Division of Rheumatology and Clinical Immunology, Humanitas Research Hospital, via A. Manzoni 56, 20089, Rozzano, Milan, Italy.
Highlights
?The concordance rates in monozygotic and dizygotic twins allows to estimate the weight of the environment. ?Only a minority of immune markers depend on hereditary factors. ?Twin studies suggest that celiac disease and psoriasis are highly heritable, different from rheumatoid arthritis or systemic sclerosis. ?Epigenetic changes are thought to be responsible for twins discordance.
Keywords
Journal of Autoimmunity
Available online 18 April 2017
Corresponding author. Division of Rheumatology and Clinical Immunology, Humanitas Research Hospital, via A. Manzoni 56, 20089, Rozzano, Milan, Italy.
Highlights
?The concordance rates in monozygotic and dizygotic twins allows to estimate the weight of the environment. ?Only a minority of immune markers depend on hereditary factors. ?Twin studies suggest that celiac disease and psoriasis are highly heritable, different from rheumatoid arthritis or systemic sclerosis. ?Epigenetic changes are thought to be responsible for twins discordance.
Keywords
- Connective tissue diseases;
- Epigenetics;
- Rheumatoid arthritis;
- Psoriasis;
- Psoriatic arthritis