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SOCS4 Prevents A Cytokine Storm And Helps To Clear Influenza Virus From The Lung

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  • SOCS4 Prevents A Cytokine Storm And Helps To Clear Influenza Virus From The Lung

    Certain influenza strains are highly virulent—they cause more serious disease and kill more people. Some of the damage is caused by the stronger immune response such strains elicit, especially in the lung. A study published on May 8th in PLOS Pathogens identifies SOCS4 as a key regulator of the immune response against influenza virus.

    Lukasz Kedzierski, Sandra Nicholson, and colleagues from the Walter and Eliza Hall Institute of Medical Research and the University of Melbourne, Australia, studied mice with a mutation in the Socs4 gene, a member of a gene family whose other members are known to be involved in regulating immune responses.

    To investigate the role of the SOCS4 protein (the product of the Socs4 gene), the researchers first tested how the mutant mice responded to infection with a virulent influenza strain. Compared with normal mice, the mutants were more sensitive to the virus; they got much sicker and many more died. When the researchers used a weaker virus, the Socs4 mutants survived but again showed more severe symptoms than mice with intact SOCS4.

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    http://www.redorbit.com/news/health/...from-the-lung/

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    Re: SOCS4 Prevents A Cytokine Storm And Helps To Clear Influenza Virus From The Lung

    The original article

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