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Scientists describe deadly immune 'storm' caused by emergent flu infections

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  • Scientists describe deadly immune 'storm' caused by emergent flu infections

    LA JOLLA, CA—February 26, 2014—Scientists at The Scripps Research Institute (TSRI) have mapped key elements of a severe immune overreaction—a "cytokine storm"—that can both sicken and kill patients who are infected with certain strains of flu virus.

    Their findings, published in this week's online Early Edition of the Proceedings of the National Academy of Sciences, also clarify the workings of a potent new class of anti-inflammatory compounds that prevent this immune overreaction in animal models.

    "We show that with this type of drug, we can quiet the storm enough to interfere with the virus-induced disease and lung injury, while still allowing the infected host to mount a sufficient immune response to eliminate the virus," said John R. Teijaro, an assistant professor in TSRI's Department of Immunology and Microbial Science and first author of the study.

    "This study provides insights into mechanisms that are chemically tractable and can modulate these cytokine storms," said Hugh Rosen, professor in TSRI's Department of Chemical Physiology and senior author of the study with Michael B. A. Oldstone, professor in TSRI's Department of Immunology and Microbial Science.

    ...

    http://www.sciencecodex.com/scientis...ections-128775

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    Re: Scientists describe deadly immune 'storm' caused by emergent flu infections

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