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First comprehensive structural data on a key flu protein—it's central to infection

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  • First comprehensive structural data on a key flu protein—it's central to infection

    Influenza A viruses spawn epidemics, global pandemics and sweeping outbreaks that kill millions of birds, yet only now have flu scientists obtained comprehensive, high-resolution structural data on a protein that is key to the very survival of an influenza virus.

    The highlighted protein is RNA polymerase, which transcribes and replicates the viral genome in the nucleus of host cells.
    Dr. Ervin Fodor and colleagues at Oxford University have shed new light on the protein in groundbreaking research that also has uncovered new sites for antiviral drugs that can take aim at vulnerable targets in RNA polymerase, a protein Fodor calls FluPolA.
    "All these sites are well-conserved regions," Fodor said in an email, referring to possible new flu-drug targets that could function across a range of flu viruses. "FluPolA is one of the most conserved proteins in flu in general. Hence, it is a good target for antiviral drug development."


    https://medicalxpress.com/news/2019-...t-central.html

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