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The seasonal flu is caused by different subtypes of Influenza A virus and typically leads to the death of half a million people each year. In order to better understand this virus and how it spreads, University of Minnesota Medical School researchers took a closer look at the cells inside the lungs. What they discovered is not only is the immune system response tuned to the amount of virus replication, it's also tuned to the viral spread. This deeper and more accurate understanding of the influenza virus and how it spreads could be the building blocks to better protective therapies for patients in the future.
"Distinct antiviral signatures revealed by the magnitude and round of influenza virus replication in vivo," was recently published in Proceedings of the National Academy of Sciences. (PNAS) and details the process in which the researchers were able to come to this conclusion. In order to study this properly, they first had to create a virus that could not could spread- it could replicate but never get into a new cell.
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"Distinct antiviral signatures revealed by the magnitude and round of influenza virus replication in vivo," was recently published in Proceedings of the National Academy of Sciences. (PNAS) and details the process in which the researchers were able to come to this conclusion. In order to study this properly, they first had to create a virus that could not could spread- it could replicate but never get into a new cell.
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